Tom Duggan's research while affiliated with Vancouver Coastal Health and other places
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Publications (2)
Systematic reviews were conducted to identify risk factors associated with the onset and progression of 14 neurological conditions, prioritized as a component of the National Population Health Study of Neurological Conditions. These systematic reviews provided a basis for evaluating the weight of evidence of evidence for risk factors for the onset...
Multiple sclerosis (MS) is a chronic disease of the central nervous system with an unidentified etiology. We systematically reviewed the literature on the possible risk factors associated with MS disease onset, relapses and progression from 1960-2012 by accessing six databases and including relevant systematic reviews, meta-analyses, case-control o...
Citations
... Although TS causes and risk factors remain elusive, tics have been linked to a complex interaction between genetic (~75%) and environmental (modifiable) factors (Krewski et al., 2017). Numerous gene (dopaminergic, serotonergic, and glutamatergic) mutations have been associated with TC (Georgitsi et al., 2016;O'Rourke, Scharf, Yu, & Pauls, 2009 In a systematic review of 22 studies, TS was associated with prenatal (maternal smoking, alcohol exposure and pregnancy complications), perinatal and neonatal adversities (Chao, Hu, & Pringsheim, 2014). ...
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... 14,15 A third study, carried out by Hedström et al., was also included by McKay and colleagues and also selected for the present article, which will be further described. 14,21 The other systematic review identified for the present study selected eight articles showing a relationship between ETS and MS. 15 Four of them reported a positive association between ETS and MS development, whereas the other four studies showed no interaction. 15 Among the twelve observational studies identified, seven of them reported higher odds of MS onset when associated with ETS. ...
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