Takahisa Kawaguchi's research while affiliated with Kyoto University and other places

... safety) in Asian patients. 71 ...

... Regarding study design, 11 (42%) were cross-sectional, five (8%) were cohort, four (15%) were case-controls, two (8%) were descriptive, two (8%) were controlled clinical trials, one (4%) was a randomized controlled trial, and one (4%) used mixed methods (qualitative and descriptive). Using the EPHPP tool to assess the methodological rigor of the studies 59 we found one study 77 with no weak characterizations, four [78][79][80][81] with one, and the remaining studies had two or more (see Table 4). ...

... The most extensive transethnic replication in childhood cancer has been done within ALL. To explore the role that SNP frequencies may play in explaining differences observed among incidence rates our findings, we obtained allele frequencies and corresponding ORs and 95% CIs from the published literature [38][39][40][41][42][43][44][45] among East Asians, SE Asians, and European populations and summarized the information in Figure 3. Several of the SNPs which have been reported to have the strongest effect in ALL, including ARID5B, IKZF1, CEBPE, CDKN1A/B, PIP4K2A, and GATA3, are included in the figure. All ORs reported in European populations show significant associations with ALL. ...

... It is worth mentioning that in a study including 472 Japanese children with ALL who were treated on a protocol that included E. coli derived asparaginase, the authors followed a candidate-gene approach aimed at replicating the associations found with GRIA1 rs4958351, NFATC2 rs6021191, and ANSN rs3832526. The authors reported no significant association between any of the variants and HSRs which suggests that the role of these variants might be influenced by ethnic specific differences in genetic structure surrounding them [40] . ...

... There are larger prospective cohorts with extensive evaluations, such as 266 the Hisayama study 18,19 and the Nagahama study. 20 We performed 14,000 extensive 267 evaluations, i.e., there were 14,000 participants who visited the CSC at both baseline and 268 2nd period surveys. These numbers were comparable to the aforementioned studies. ...

... Our previous study of targeted loci conducted within the Tokyo Children Cancer Study Group (TCCSG) showed that risk associations for SNPs in ARID5B, IKZF1 and PIP4K2A transfer to the Japanese population. 4 As a next step, this current study included two independent GWAS series assembled through TCCSG and the Japanese Pediatric Patients included in the TCCSG and JPLSG series comprised predominately of B-cell ALL (TCCSG, 93%; JPLSG, 100%), greater numbers of males (TCCSG, 52%; JPLSG, 58%) than females, and showed the majority to be between 1 and 6 years of age at (TCCSG, 69%; JPLSG, 57%). We first performed a discovery analysis in the TCCSG series and observed a novel association represented by SNP rs116977518 (OR=1.99, ...

... Patients' data and oncological outcomes registered in two clinical trials of Japanese Foundation of Multidisciplinary Treatment of Cancer (JFMC) studies (37 and 41) were pooled [15,16]. ...