September 2023
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5 Reads
International Journal of Pharmacology
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September 2023
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5 Reads
International Journal of Pharmacology
January 2023
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5 Reads
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1 Citation
February 2022
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57 Reads
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2 Citations
Journal of Molecular Neuroscience
In relation to dietary intervention in individuals with autism spectrum disorder (ASD), certain food constituents especially gluten and casein are recognized to be challenging and should be restricted. In this study, levels of glutathione S-transferase, glutathione, lipid peroxides, serotonin (5-HT), interleukin-6 (IL-6), glutamate, and gamma aminobutyric acid (GABA) were measured in the brain homogenates of ASD rodent model. Rats were treated either with single dose clindamycin (30 mg/kg) or with propionic acid (PPA) (250 mg/kg) for 3 days and then fed a standard diet, casein-rich diet (CRD), or gluten-rich diet (GRD). The obtained data demonstrates that clindamycin and PPA induced oxidative stress, which was slightly affected by CRD. A marked increase in the proinflammatory cytokine (IL-6) concentration found in clindamycin- and PPA-treated groups was lower in CRD fed rats. Both CRDs and GRDs produced similar trends in glutamate levels. 5-HT levels were higher in the clindamycin- and PPA-treated groups and increased with a GRD but were less affected by a CRD. CRD could be less deleterious compared to GRD. Although the underlying cause of gastrointestinal symptoms in patients with ASD is not exactly known, the most widely accepted one is the opioid theory which is related to GRD and CRD.
... Rodent models, including mice and rats, have proven particularly effective in studying the behavioral effects of dietary peptides. Studies have demonstrated that rats fed a diet containing gluten and casein exhibit increased repetitive behaviors, decreased social interactions, and altered levels of certain neurotransmitters compared to control rats [49]. Another study showed that mice fed a diet containing gluten and casein exhibited decreased social interaction and increased repetitive behaviors [50]. ...
February 2022
Journal of Molecular Neuroscience