December 2022
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22 Reads
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7 Citations
Chemical Engineering Journal
Inefficient tumor-targeted delivery and uncontrolled drug release are the major obstacles in cancer chemotherapy. Herein, inspired by the targeting advantage of coronavirus from its size and coronal structure, a coronal biological metal-organic framework nanovehicle (named as corona-BioMOF) is constructed for improving its precise cancer targeting ability. The designed corona-BioMOF is constructed as the carriers-encapsulated carrier model by inner coated with abundant protein-nanocaged doxorubicin particles and external decorated with high-affinity apoferritin proteins to form the spiky surface for constructing the specific coronal structure. The corona-BioMOF shows a higher affinity and enhanced targeting ability towards receptor-positive cancer cells compared to that of MOF-drug composites without spiky surface. It also exhibits the hierarchical wrapping pattern-endowed controlled lysosome-specific drug release and remarkable tumor lethality in vivo. Moreover, water-induced surface defect-based protein handle mechanism is first proposed to shape the coronal-BioMOF. This work will provide better inspiration for nanovehicle construction and be broadly useful for clinical precision nanomedicine.
![The major mechanisms of tumor resistance. (A) Biological barriers[48]. Reproduced with permission from ref[48]. Copyright 2020 American Chemical Society. (B) Drug inactivation[40]. Reproduced with permission from ref[40]. Copyright 2021 American Chemical Society. (C) DNA damage repair[61]. Reproduced with permission from ref[61]. Copyright 2022 the authors. (D) Immune evasion[69]. Reproduced with permission from ref[69]. Copyright 2020 Science.](https://www.researchgate.net/publication/364456664/figure/fig1/AS:11431281094512637@1667480669278/The-major-mechanisms-of-tumor-resistance-A-Biological-barriers48-Reproduced-with_Q320.jpg)
![The common drug loading methods on the MOFs. (A) One-pot synthesis[84]. Reproduced with permission from ref[84]. Copyright 2014 American Chemical Society. (B) Biomimetic mineralization[85]. Reproduced with permission from ref[85]. Copyright 2015 the authors. (C) Post-synthetic loading[86]. Reproduced with permission from ref[86]. Copyright 2018 the authors.](https://www.researchgate.net/publication/364456664/figure/fig3/AS:11431281094492727@1667480669496/The-common-drug-loading-methods-on-the-MOFs-A-One-pot-synthesis84-Reproduced-with_Q320.jpg)
![of the major junctions of MOFs in biomedical application. (A) Drug delivery[96]. Reproduced with permission from ref[96]. Copyright 2021 American Chemical Society. (B) Intrinsic therapeutic MOF[42]. Reproduced with permission from ref[42]. Copyright 2021 Wiley-VCH. (C) Biological imaging[102]. MWTT, microwave thermal therapy; MWDT, microwave dynamic therapy; VEGF, vascular endothelial growth factor. Reproduced with permission from ref[102]. Copyright 2022 Elsevier. (D) Biomimetic catalysis[105]. Reproduced with permission from ref[105]. Copyright 2017 American Chemical Society.](https://www.researchgate.net/publication/364456664/figure/fig4/AS:11431281094532161@1667480669534/of-the-major-junctions-of-MOFs-in-biomedical-application-A-Drug-delivery96_Q320.jpg)
![of the therapeutic application of MOFs to overcome tumor resistance. (A) Improving delivery[55]. Reproduced with permission from ref[55]. Copyright 2021 the authors. (B) Overcoming obstacles[40]. Reproduced with permission from ref[40] . Copyright 2021 American Chemical Society. (C) Polypharmacy and combination therapy[36]. Reproduced with permission from ref[36]. Copyright 2021 Elsevier. (D) Weakening immune evasion[44]. Reproduced with permission from ref[44]. Copyright 2022 Wiley-VCH. (E) Collapsing the antioxidant defense system[118]. Reproduced with permission from ref[118]. Copyright 2021 Wiley-VCH.](https://www.researchgate.net/publication/364456664/figure/fig5/AS:11431281094512638@1667480669593/of-the-therapeutic-application-of-MOFs-to-overcome-tumor-resistance-A-Improving_Q320.jpg)
