Sean Palfrey's research while affiliated with Boston Medical Center and other places

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Publications (3)


Elevated Blood Lead Levels in Infants and Children in Haiti, 2015
  • Article
  • Full-text available

November 2018

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131 Reads

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11 Citations

Public Health Reports

Chris Carpenter

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Judith Palfrey

Objective:: Few studies have reported blood lead levels (BLLs) in Haitian children, despite the known presence of lead from environmental factors such as soil, water, leaded paint and gasoline, improperly discarded batteries, and earthquakes. We sought to determine the prevalence of elevated blood lead levels (EBLLs) among healthy Haitian children. Methods:: We enrolled children aged 9 months to 6 years from 3 geographic areas in Haiti (coastal, urban, and mountain) from March 1 through June 30, 2015. We obtained anthropometric measurements, household income, potential sources of lead exposure, and fingerstick BLLs from 273 children at 6 churches in Haiti. We considered a BLL ≥5 μg/dL to be elevated. Results:: Of 273 children enrolled in the study, 95 were from the coastal area, 78 from the urban area, and 100 from the mountain area. The median BLL was 5.8 μg/dL, with higher levels in the mountain area than in the other areas ( P < .001). BLLs were elevated in 180 (65.9%) children. The prevalence of EBLL was significantly higher in the mountain area (82 of 100, 82.0%; P < .001) than in the urban area (42 of 78, 53.8%) and the coastal area (56 of 95, 58.9%; P < .001). Twenty-eight (10.3%) children had EBLLs ≥10 μg/dL and 3 (1.1%) children had EBLLs ≥20 μg/dL. Exposure to improperly discarded batteries ( P = .006) and living in the mountain area ( P < .001) were significant risk factors for EBLLs. Conclusions:: More than half of Haitian children in our study had EBLLs. Public health interventions are warranted to protect children in Haiti against lead poisoning.

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New Initiatives to Improve HPV Vaccination Rates

March 2016

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16 Reads

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4 Citations

Human Vaccines & ImmunotherapeuticsHuman Vaccines & Immunotherapeutics

Citations (3)


... Children absorb nearly five times as much lead compared to adults due to increased hand-to-mouth contact, and lead is especially toxic in undernourished children who absorb increased lead when lacking in other nutrients (World Health Organization, 2021). Despite Haiti phasing out leaded gasoline in 1998, a 2015 study found that over half of Haitian children had lead levels greater than ≥ 5 µg/dL (Carpenter et al., 2019). Exposure to improperly discarded car and household batteries appeared to be a primary driver of increased lead levels with over half the children reporting walking past discarded batteries on their way home from school. ...

Reference:

Health of Post-Institutionalized Haitian Children Adopted to the United States
Elevated Blood Lead Levels in Infants and Children in Haiti, 2015

Public Health Reports

... Chronic systemic exposure to Pb might cause hypertension, heart disease, stroke, and chronic kidney disease due to its nondegradability and bioaccumulation in organisms (3). Especially, even well below 10 μg/L (level of concern) lead in pregnant woman blood can cause miscarriage, premature delivery, low birth weight, and subsequent developmental delays of children (4)(5)(6)(7). Therefore, the effective removal of lead in liquid media is of great significance to protect environmental safety and human health. ...

High rates of raised blood lead concentrations in Haitian infants and children

The Lancet Global Health

... In fact, standardizing both the quality and the quantity of information could lead to an increase in adherence to the various vaccination awareness campaigns, which already must overcome the prejudices and psychological factors that make promotion and prevention interventions complex. Surely, investing in promotion campaigns, as in the case of polio, for example, would both improve the cost-benefit balance (making it even more favorable than the balance achieved by primary prevention activities alone) and equalize vaccination coverage between the two genders, which still show a substantial gap [127,128]. ...

New Initiatives to Improve HPV Vaccination Rates
  • Citing Article
  • March 2016