January 1996
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8 Reads
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28 Citations
Clinical Chemistry
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January 1996
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8 Reads
·
28 Citations
Clinical Chemistry
October 1994
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505 Reads
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128 Citations
Clinical Chemistry
Starburst dendrimers are novel, water-soluble polymeric materials, with a well-defined composition and structure. In our application, we used dendrimers composed of poly(amidoamine) groups to which we coupled several specific antibodies, to investigate potential formats based on radial partition immunoassay. The coupled antibodies have retained their stability and immunological binding after coupling, both in solution and when immobilized onto a solid support. On the basis of our feasibility studies with model systems, we conclude that immunoassays can be developed with performance equivalent to or better than that in many established systems. By application of a mixture of the dendrimer-coupled antibody and the analyte of interest to the solid phase, we have investigated the performance characteristics of solution-phase immunoassays. Our experiments demonstrate enhanced sensitivity for creatine kinase MB isoenzyme (CKMB), thyrotropin, and myoglobin assays and reduced instrumental analysis time for the CKMB assay.
... This method is utilized for the preparation of different types of dendrimers, especially PAMAM starburst dendrimers. The divergent approach offers several benefits like ease of modifiable surface molecules by reactive end groups located at the outer surface layer [23]. The other key advantage of this approach is that both physical and chemical features of dendrimers can be designed to our specific requirement [24,25]. ...
January 1996
Clinical Chemistry
... Trastuzumab-dendrimer conjugates are also effectively transported to cancer cells which have been confirmed by viability tests and 19 F MRI. The utility of antibodies for in vitro applications (6), cancer therapeutics (7)(8)(9)(10), and in tumor MRI (11) has been reported. ...
October 1994
Clinical Chemistry