Richard L. Greenman's research while affiliated with Stanford University and other places
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Publications (6)
Four patients are described with documented coccicioidal synovitis of the knee joint. In two of them, no previous diagnosis of coccidioidomycosis had been made prior to diagnosis of coccidioidal synovitis. The other two had active disease after courses of amphotericin B administered both parenterally and intra-articularly for disseminated coccidioi...
A penicillin-sensitive strain of Staphylococcus aureus was used to evaluate the efficacy of six antibiotic combinations in the therapy of an experimental infection in mice. One
hour after intraperitoneal infection, animals were treated with penicillin G, erythromycin, clindamycin, gentamicin, or tobramycin
singly or in various combinations of two o...
Particles containing DNA polymerase (Dane particles) were purified from the plasma of chronic carriers of hepatitis B antigen. After a DNA polymerase reaction with purified Dane particle preparations treated with Nonidet P-40 detergent, Dane particle core structures containing radioactive DNA product were isolated by sedimentation in a sucrose dens...
Experiments were done to show that the human hepatitis B antigen (HBAg)-associated DNA polymerase is a component of Dane particles and their antigenically distinct cores prepared by Nonidet P-40 detergent treatment of Dane particles. Before detergent treatment, the DNA polymerase was precipitated by serum containing anti-HB surface antigen (anti-HB...
DNA polymerase activity was detected in each of eight preparations of concentrated human hepatitis B antigen (HBAg) rich in Dane particles prepared by high-speed centrifugation of antigen-positive human plasma and in none of seven control preparations prepared in the same way from HBAg-negative plasma. The incorporation of (3)H-thymidine-methyl-5'-...
Citations
... Les effets de S. aureus ont été comparés avec ceux du tampon de transport dans le cas de rats traités par voie intra-péritonéale par S. aureus seul (contrôle négatif), S. aureus plus Ctl (1.5 mg/kg) et Ctl seul (1.5 mg/kg) (Rabbi et al., 2014). Le contrôle positif correspond à des rats traités avec S. aureus plus Penicilline-Streptomycine (35,000 units/Kg de Pénicilline aqueuse plus 18 mg/Kg de Streptomycine) (Sigma-Aldrich Produktions GmbH, Steinheim, Germany) (Steigbigel et al., 1975 En tenant compte de l'action anti-inflammatoire et de la modulation de l'inflammation intestinale par Ctl dans les cas de colite (Rabbi et al., 2014) on a cherché à évaluer dans chaque groupe l'état de l'inflammation systémique en controlant dans le plasma les concentrations TNF-α et IL-1β, deux cytokines pro-inflammatoires majoritaires (Knuefermann et al., 2004). La LDH plasmatique a aussi été évaluée en tant qu'index de détérioration (Cofiell et al., 2015). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273664276955146-1442258056226_Q64/Roy-Steigbigel.jpg)
... The recent use of the Fibroptic knee arthroscope and the visualization of involved synovium for biopsy should lead to more positive results. Successful synovectomy in coccidioidal synovitis has been reported (Greenman et al. 1975, Pollock et al. 1967, Sotele-Ortiz 1955). Two out of four patients reported by Greenman et al. had persistant synovial infection after a prolonged course of intravenously and intra-articularly administered Amphotericin B and the active disease could be eradicated only after synovectomy. ...
... It was encapsi dated within the cores of the Dane particles, and consequently, it could not accept exogenously added nucleic acids as templates. The encapsidated DNA polymerase could consequently only elongate an "endogenous" DNA strand, which was also packaged in the same HBV particle (5). This breakthrough cannot be appreciated enough. ...
... HBV encoded proteins are critical for completion of the HBV life cycle and generate infectious HBV virions containing HBV rcDNA. rcDNA repair requires various repair enzymes, and the only viral protein which contains an enzymatic activity is POL [58][59][60]; however, the inhibition of the DNA polymerase activity of HBV POL does not affect HBV or DHBV cccDNA formation in cells [61][62][63][64][65]. Therefore, the viral proteins most likely play limited roles in rcDNA repair in cccDNA biogenesis. Consistent with this notion, the lack of surface antigens in HBV or DHBV does not lead to a decrease of cccDNA formation. ...
... It contains four open reading frames (ORFs) that overlap completely or partially. The ORFs encode all viral regulatory elements: four promoters (core, S1, S2, and X), two enhancers (Enh1, Enh2), and signals of replication (DR1, DR2), polyadenylation, and encapsidation (ε) [25,26]. Post-double-strand DNA break, cellular DNA repair processes commence through homologous recombination (HR) or non-homologous end joining (NHEJ). ...
