Richard A. Schiltz's scientific contributions
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Publications (3)
Methyl-5(6)-phenylsulfinyl-2-benzimidazole carbamate (Oxfendazole) (Syntex Research, Syntex (U.S.A.), Inc., Palo Alto, Calif. 94304) a new potent anthelminthic, was tested at nine dosage levels against gastrointestinal and lungworm helminths in naturally infected lambs. A modified least significance difference test (P= 0.05) was used on log transfo...
1. Human hepatic "acid" beta-galactosidase preparations, which had been purified approximately 250-fold, were examined for activities toward 4-methylumbelliferyl beta-galactosylceramide, lactosylceramide, galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosyl-glucosylceramide(GM1-ganglioside) and galactosyl-N-acetylgalactosaminyl-galacto...
Citations
... [2 -6] Benzimidazol-2-yl-carbamates have proven anthelmintic activity. [7,8] In continuation of our research interests, several new classes of 1-[(substituted carbamoyl)amino]-1H,3H-1l 5 - [1,3,2]oxazaphospholo [3,4-a]benzimidazol-1-ones were synthesized and characterized by spectral data and were screened for their antifungal and antibacterial activity. ...
... The dose rate of each anthelmintic in a combination with an additive effect should be the same as that recommended when the anthelmintics are used separately. The efficacy of anthelmintics against susceptible strains of most economically important parasites is generally high, often 99-100%, when administered at the recommended dose rates ( Kistner et al., 1979;Kettle et al., 1981Kettle et al., , 1982Preston, 1984;Echevarria et al., 1991). However, for all anthelmintics, there are some nematode species against which such high levels of efficacy are not achieved. ...
... Scientists at (1) Smith Kline Corporation discovered albendazole [43], oxibendazole [44]and fenbendazole [45] and (2) Syntex developed oxfendazole [46]. The synthetic steps required to synthesize selectively hydrogenated to the required diamine. ...
