R A Burnett's research while affiliated with University of Aberdeen and other places
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Publications (16)
AimsClinical management of premalignant and malignant lesions of the larynx is dependent on histopathological evaluation. The Scottish Pathology Consistency Group assessed interobserver variation in the evaluation of laryngeal dysplasia.Methods and resultsOne hundred laryngeal biopsies ranging from normal to invasive carcinoma were assessed. The ov...
The Goseki grouping of gastric adenocarcinoma has been suggested as a possible prognostic factor. In those centres where it is used, it may be valuable to assess the Goseki grouping of a tumour on the initial diagnostic biopsy as well as on the resection specimen since it may in theory influence management. We examined the robustness of Goseki grou...
Clinical management of premalignant and malignant lesions of the larynx is dependent on histopathological evaluation. The Scottish Pathology Consistency Group assessed interobserver variation in the evaluation of laryngeal dysplasia.
One hundred laryngeal biopsies ranging from normal to invasive carcinoma were assessed. The overall Kappa result of...
The Scottish Pathology Consistency Group has in previous studies examined the consistency of histopathological reporting of biopsies from the cervix, bladder, bronchus, and rectum. In the current study, consisting of 100 needle biopsy specimens of the prostate, a single hematoxylin-eosin (H&E) slide from each case was circulated in batches of 10 to...
Adenocarcinoma of the anal glands is very rare but it is an important lesion to recognise as with early diagnosis, it has an excellent prognosis. Because it involves the submucosa widely and penetrates the mucosa late, it can be mistaken for metastatic gastrointestinal carcinoma, or tumour arising in sinuses and fistulae. Two cases, in a 44 year ol...
To evaluate the ability of histopathologists to sub-classify non-small cell lung carcinomas on bronchial biopsy material using the current World Health Organisation (WHO) classification.
Twelve histopathologists each reviewed 100 randomly selected bronchial biopsy specimens which had originally been reported as showing non-small cell lung carcinoma...
To evaluate the ability of histopathologists to classify lung carcinomas on bronchial biopsy material using the current World Health Organisation (WHO) classification.
Eleven histopathologists each reviewed 100 randomly selected bronchial biopsy specimens which had originally been reported as showing lung carcinoma. A single haematoxylin and eosin...
To study the consistency of reporting of abnormal rectal biopsy specimens, especially in the differentiation of inflammatory bowel disease from other causes of abnormality.
Sixty rectal biopsy specimens were identified from patients presenting with bloody diarrhoea. These were then circulated to the 11 consultant pathologists in the study who fille...
Sections from 90 urinary bladder biopsy specimens were examined by 11 consultant histopathologists with varying experience to determine the appropriateness of existing pathology terminology. Analysis with kappa statistics showed fair to good agreement in the grading and staging of transitional cell carcinoma. There was also reasonable agreement in...
Sections from 100 cervical biopsy specimens were studied by 12 consultant histopathologists to determine the robustness of the existing pathology terminology and classification. Analysis by kappa statistics showed good agreement in the diagnosis of CIN 3 and squamous carcinoma but an inability to distinguish accurately between the lesser grades of...
Despite the reservations of many pathologists there are plainly advantages to be gained from the adoption of EQA programmes. These schemes are certainly capable of making a contribution towards the maintenance of high standards of accuracy in both laboratory reporting and technical performance and may have a role to play in enabling pathologists to...
Citations
... Although all ED grades carry the risk for malignant transformation [6], until this point of time, higher grades of ED remain the most critical risk factor for SCC development [18,48,[51][52][53][54]. As a result, the accuracy of ED grading is desired. ...
... Cervical cancer visual screening methods involve visual inspection of the cervix with acetic acid (VIA) and Lugol's iodine (VILI) [4]. These methods are easy to perform, cheap, and do not require sophisticated equipment. ...
... A study evaluated WHO 1973 classification from 11 pathologists, and inter-observer agreement was slight to moderate (κ ൌ 0 . 1 9 െ 0 . 4 4 ) [9]. Another study measured inter-observer agreement among 6 pathologists and showed that WHO/ISUP classification is slightly better than WHO 1973 [10]. ...
... Las habilidades de identificación y clasificación de las lesiones intraepiteliales escamosas están bien apoyadas por los recursos existentes (Kurman et al. 2010), pero es poco conocida la contribución, la importancia y los beneficios de otros recursos de apoyo diagnóstico, que permiten mejorar los resultados, mediante apoyo a las decisiones de las estrategias científicas, identificando y evitando sesgos asociados. Los errores en los hallazgos histológicos han sido bien documentados (Joste, Crum, and Cibas, 1995;Tritz et al., 1995), el estudio histológico de las lesiones intraepiteliales de cuello uterino presenta una notable variabilidad inter e intraobservador, y ha sido demostrado que los diagnósticos de NIC no son totalmente reproducibles (Grenko et al., 2000;Ismail et al., 1989;Kalof and Cooper, 2007;Malpica et al., 2005;Park et al., 1999;Parker et al., 2002;Robertson et al., 1989;Stoler, Schiffman, and ALTS Group, 2001;de Vet et al., 1990), especialmente los de las NIC II (Stoler et al., 2015). ...
... In contrast, histopathological EQA schemes were initially difficult to initiate and organize, because the results being compared were interpretive diagnoses, and outlier opinions would be attributed to an individual. 32 Nevertheless, participation in EQA aligned to the scope of a histopathologist's practice is now firmly established, including the procedures for dealing with persistently poor performance. ...
... Largely determined by morphology, primary lung cancers are histologically classified into small cell lung cancers (SCLC) and nonsmall cell lung cancers (NSCLC), with the latter including adenocarcinoma (LUAD), squamous cell carcinoma (LUSC), and largecell neuroendocrine carcinoma (LCNEC) as the main histologic subtypes. However, consensus histologic confirmation can sometimes be challenging and therefore impacts optimal treatment choices 3,4 . The molecular mechanisms determining the tumor histology are unknown. ...
... 3 In particular, the Geboes classification includes histological findings during remission and is considered easy to use clinically, and basal plasmacytosis (BP) is considered an early and highly specific finding in patients with inflammatory bowel disease. [4][5][6][7][8][9][10] The endoscopic findings of ulcerative colitis can be evaluated according to the Matts classification, Mayo endoscopic subscore, 11 Ulcerative Colitis Endoscopic Index of Severity, 12 Baron index, 13 and Rachmilewitz Endoscopic Index. 14 Although the most important variables differ depending on the method used for classification, the grade of inflammation is evaluated on the basis of the presence or absence of factors such as red signs, loss of visible vascular patterns, granular mucosa, friable mucosa, spontaneous bleeding, and erosions/ulcers (E/U). ...
... Studies aiming to measure the diagnosis agreement between pathologists for lung carcinomas report highly different ranges, from as low as 0.25 to as high as 0.88 as measured by the kappa statistic [31][32][33][34][35][36] , with the agreement being typically lower for poorly-differentiated cases. In current clinical workflows, IHC is typically used to attempt to reach a diagnosis when encountering poorly-differentiated cases; however, IHC is not always sufficient (IHC has a reported AUC of 0.94 11 ). ...
... Some anal adenocarcinomas are theorized to originate from the glandular cells of the transitional zone mucosa (colorectal type), whereas others are believed to arise from the anal canal glands (extra mucosal). The latter is more commonly associated with chronic anal fistulas, which, when untreated, may trigger malignant transformation anal gland adenocarcinomas [4]. ...
... This score is subsequently used by the physician to determine the most appropriate treatment for the patient. However, many studies have reported inter-observer variability between pathologists in the process of labeling cancerous sections of tissue (more than 30% of discrepancy in Gleason scoring) [4][5][6]. ...
