Pablo Soro-Barrio's research while affiliated with The Francis Crick Institute and other places

... A number of previous studies have examined the effect of high sugar diet on other immune cells. For example, a study found that increased intake of artificial sweeteners such as sucralose negatively influenced CD8 + T cells (47). Mice treated with large amounts of sucralose showed CD8 + T cell dysfunction among mice challenged with Listeria monocytogenes or murine models of cancer (47). ...

... The sparsity of information on glycan 3D structures, occupation and identity at different sites contributes greatly to our lack of understanding of the many different functions that glycans and glycosylation play in biology. Yet remarkable advances are continuously made in the development of new high-precision tools and techniques [16][17][18][19][20][21][22][23][24][25][26] that allow us to shed light on different aspects of the glycome. Within this framework, the potentials of glycobioinformatics [27][28][29][30][31][32] databases and resources and of high-performance computing (HPC) molecular simulations 7,8 are extraordinary, especially within a context where information from multiple sources is required to decipher the GlycoCode 33 . ...

... As shown in figure 5A, the forced overexpression of Sema3a was associated with the significant downregulation of Grem1, a BMP inhibitor that has been shown to promote epithelialisation of mesenchymal PDAC cells. 50 Next, we performed gene set enrichment analysis on the list of differentially expressed genes using the GSEA method 51 (figure 5B,E). Following the overexpression of Sema3a, we observed the enrichment of gene programmes related to cytoskeleton remodelling and the activity of Rho GTPases (figure 5B, online supplemental table S2). ...

... For a standardized analysis, the volume of blood collected may vary between different species [5,6]. In small animals, the volume of blood that is practical to sample is often lower than in larger animals and humans, or lower in case of longitudinal studies due to repeated sampling [7,8]. ...

... Pioneering work has revealed that the developmental capacities of each cardiac progenitor pool are highly related to the spatial-temporal constriction during the specification of NM cells (Lescroart et al. 2018;Ivanovitch et al. 2021;Zhang et al. 2021). Temporally inducible lineage tracing indicates that E6.5 Mesp1 + cells mostly contribute to LV, whereas E7.25 Mesp1 + cells give rise to RV, atria, OFT, and inflow tracts (IFT) (Lescroart et al. 2018). ...

... Elegant fate-mapping experiments have suggested that both heart fields are specified around the onset of Mesp1 expression [13•]. Intriguingly, a more recent study provided the first mechanism for a distinct spatiotemporal sequence of specification of each heart chamber very early in development (E6 in mice) [17]. Thus, given that both heart fields are specified early during heart development, dysregulation of CPCs can result in potentially severe CHD. ...