Ning Jiang's research while affiliated with State Key Laboratory of Medical Genetics of China and other places

... In vitro experiments demonstrated that IL-4 enhanced the phagocytic capacity of Wang, Wang, Wu, Cai, Cui, Yang, Sun, Mao and Wang microglial cells and alleviated neuroinflammation. In the current study, we found that IL-4 treatment did not have an impact on microglia activation in sham rats or the regulation of inflammation and phagocytosis in control BV2 cells, which is consistent with the results of a recent study [33]. It is worth noting that previous studies have mainly focused on the long-term neuroprotective effects of IL-4 [22,34], whereas our results demonstrate its beneficial effects on neurofunction occurring at 5 days post-SAH. ...

... 15 Studies have shown that the presynaptic membrane NMDAR is involved in the regulation of the CNS via mediation of Glu input in addition to playing a key role in depression induced by CUMS. 16 Generally known as a voltage-activated Ca 2+ channel (VACC) subunit, α2δ-1 (encoded by CACNA2D1), is the binding site for gabapentinoids. [17][18][19] α2δ-1 is highly expressed in the hypothalamus, particularly in the PVN. ...

... Thus, the absence or reduction of DAT function results in impaired synaptic DA homeostasis [48]. Previous studies showed SM neurotoxicity in various experimental models as well as cognitive and emotional disorders in veterans exposed to this compound, as recently reviewed in [49]. Neurological complications after SM poisoning encompassed sensory nerve impairments [50], motor nerve disturbances [51], retinal abnormalities [52], chronic neuropathic symptoms [53], and mental health problems such as anxiety, depression, or cognitive decline [54] and persisted even decades after exposure [55]. ...

... More than 97% iPSCs were able to express pluripotency markers such as NANOG, OCT4, and SSEA4 along with normal karyotype. The developed iPSCs line could be considered one of the valuable resources for studying sAD pathogenesis in vitro [53]. Moreover, all the cell lines developed for AD can be seen in Supplementary Table S2. ...

... L. Zhang и соавт. [38] обнаружили, что нервные клетки человека, полученные из иПСК от пациентов с БА, проявляли различную восприимчивость к окислительному стрессу. Реакция нервных клеток на окислительный стресс является важным механизмом когнитивной дисфункции и старения. ...

... Once the reprogramming is achieved, morphological changes can be appreciated in the cultured cells forming ESCs-like colonies, which may be collected and clonally expanded. These clonal cells are cultured for several passages to ensure they conserve their characteristic morphology (Fig. 2.2;Zhang et al., 2020). ...

... The potential applications of iPSCs are limited due to several barriers that act as roadblocks to prevent efficient reprogramming [7, 10, 211,213]. To realize the full potential of this technology, attempts have been made to reprogram a diverse array of cell types derived from different cell sources, some of which are discussed in this review, namely keratinocytes which are easier to obtain, isolate and reprogram, urine cells which are easier to collect and universally applicable to all irrespective of age and gender, and PBMCs which is the most commonly collected sample for diagnostics (also Sendai viral transduction Craniometaphyseal dysplasia [167] Bernard-Soulier syndrome [186] Schizophrenia [187] Early onset Alzheimer's disease [188] Late onset Alzheimer's disease [189] Triple negative breast cancer [190] Parkinson Disease [191] Sickle cell anemia [192] Autism Spectrum Disorder [193] Werner syndrome [194] Amyotrophic lateral sclerosis [195] Familial Platelet Disorder with associated Myeloid Malignancy [196] Autism-related Activity-Dependent Neuroprotective Protein [197] Cri du Chat Syndrome [198] Attention deficit hyperactivity disorder [199] Catecholaminergic polymorphic ventricular tachycardia [200] Noonan syndrome [155] Pulmonary arterial hypertension [201] β-thalassemia [202] Episomal vectors Alzheimer's disease [203,204] Parkinson Disease [205] Cystic fibrosis [206] α-1 antitrypsin deficiency [206] Sickle cell anemia [207] Duchenne muscular dystrophy [173] Young-onset Parkinson's disease [208] Amyotrophic lateral sclerosis [178] Multiple Sclerosis [176] Immunoglobulin A nephropathy [209] Maple syrup urine disease [210] other promising cell sources such as adult stem cells; not discussed in this review due to their isolation in an invasive manner) to generate mouse and human iPSCs efficiently. The origin of cell type dictates the path to pluripotency and involves crucial events such as loss of somatic cell identity, MET (in cell types which are of non-epithelial origin), the degree to which they undergo developmental reversion, and reactivation of the pluripotency network [62]. ...

... were introduced by Pandya et al. (2017). and Xu et al. (2019). Pandya et al.'s approach involves a similar two-step process to generate MGLs within a month. ...

... γ-H2A.X is H2A.X (a specialized histone H2A variant) phosphorylated at Ser 139 via ATM serine/threonine kinase and ATR serine/threonine kinase (39). γ-H2A.X is widely considered as a marker of DNA damage (40,41). The results of the present study demonstrated that Ad-hTK1/hTIMP1 significantly decreased γ-H2A.X expression in H/R-treated CMVECs, indicating reduced DNA damage in H/R-treated CMVECs following transfection with Ad-hTK1/hTIMP1, which may be attributed to decreased oxidative stress. ...

... Additionally, the phenyl ring of Tyr907 induces the π-π stacking interaction with the aryl ring. Additionally, an auxiliary appendage with a linking side chain is commonly conjugated with the polycyclic core as a solvent accessory region in the AD site [20][21][22][23] (Figure 3). leading to enhancing their effectiveness and pharmacokinetic characteristics [17,18]. ...