Laura J. Friedlander's research while affiliated with University of Colorado and other places

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Publication (1)

FIG. 1. Gating strategy used to identify DC subsets and expression of...
TABLE 1 . Study subject characteristics a Study type and parameter...
FIG. 2. Expression of Bcl-2 and caspase-3 by blood mDCs. Intracellular...
TABLE 2 . Expression of Bcl-2 and caspase-3 by blood pDCs from...
+2 FIG. 3. Expression of caspase-3 and Bcl-2 by blood mDCs following ART....
Blood Myeloid Dendritic Cells from HIV-1-Infected Individuals Display a Proapoptotic Profile Characterized by Decreased Bcl-2 Levels and by Caspase-3+ Frequencies That Are Associated with Levels of Plasma Viremia and T Cell Activation in an Exploratory Study
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  • Jan 2011
Reduced frequencies of myeloid and plasmacytoid dendritic cell (DC) subsets (mDCs and pDCs, respectively) have been observed in the peripheral blood of HIV-1-infected individuals throughout the course of disease. Accumulation of DCs in lymph nodes (LNs) may partly account for the decreased numbers observed in blood, but increased DC death may also...
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Citations

... PBMC: Blood samples were obtained from healthy adults (N = 5) and PBMC isolated using standard Ficoll-Hypaque density gradient centrifugation, cryopreserved and stored in liquid nitrogen as previously detailed. [75][76][77] All the study subjects participated voluntarily and gave written, informed consent. This study was approved by COMIRB. ...
Reference: Granzyme B+ CD4 T cells accumulate in the colon during chronic HIV-1 infection
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