L Mitchell's research while affiliated with The Newcastle upon Tyne Hospitals NHS Foundation Trust and other places

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Publications (9)


Preventing congenital syphilis - a regional audit of syphilis in pregnant women seen in Genitourinary Medicine services
  • Article

November 2013

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38 Reads

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11 Citations

International Journal of STD & AIDS

J Hussey

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L Mitchell

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Y Hew

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[...]

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Genitourinary case records of 42 pregnant women with syphilis were reviewed as part of a regional audit following the re-emergence of congenital syphilis in the north east of England. National standards, from the British Association of Sexual Health and HIV guidelines on managing syphilis in pregnancy, were met in the majority of cases with 69% being treated according to national guidance and all cases completing treatment. Locally developed standards on multidisciplinary working and communication were less well met, with particular issues regarding the documentation of pregnancy outcomes in GUM records and communication between specialities being highlighted. A regional good practice guide has been developed and implemented to address standards not met, reduce adverse outcomes and prevent future cases of congenital syphilis.

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P87 Development of regional good practice arrangements for the management of pregnant women with syphilis and their babies in the north east of England
  • Article
  • Full-text available

June 2012

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13 Reads

Sexually Transmitted Infections

Background The re-emergence of congenital syphilis in the North East and outcomes of a regional audit prompted the development of regional good practice arrangements in managing pregnant women with syphilis and their babies. Aims Guidance documents for the various clinical specialties were present for the management of pregnant women with syphilis in our region, but not a clear description of the whole patient (mother and baby) pathway. The overall aim of the good practice arrangement was to clarify precise roles of clinicians looking after these pregnant women, prompt re-testing of syphilis based on subsequent risks and concerns, create referral pathways and encourage multidisciplinary communication in management of pregnant women with syphilis. Method Current national guidance was reviewed and discussed between Northern BASHH group, Health Protection Agency (HPU and virology), regional Paediatric Infectious Diseases and Antenatal screening coordinators. Audit outcomes highlighted areas needing improvement and these were addressed including use of named rather than numbered GUM serology specimens. Results The good practice arrangement outlines clearly the patient journey from diagnosis to delivery and follow-up of her baby. It is divided into different stages, with each outlining clearly who is responsible for care, locally recommended practice and referring to national guidance where indicated for the management of that stage. These stages are antenatal screening and referral process to GUM, management of positive results in mother, investigations of baby at birth, follow-up of babies born to mothers with positive syphilis results and treatment of baby with suspected congenital syphilis. Good practice is included on the management of mothers who do not attend GUM follow-up, communication to those involved in care and a named lead paediatrician in every hospital trust in the North East region has been created.

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P86 Audit on the management of women with syphilis in the north east of England

May 2012

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8 Reads

Sexually Transmitted Infections

Background The increase in syphilis in women over the last 10 years in the North East and re-emergence of congenital syphilis, as presented at BASHH spring meeting 2011, prompted a review of current management of pregnant women with syphilis. Objectives To identify any risk factors in women being diagnosed with syphilis in the region and to review the current management of pregnant women with syphilis. Methods A regional audit involving all Genitourinary Urinary Medicine (GUM) departments in the North East was conducted. Case notes of all women diagnosed with syphilis from 2006 to 2010 were obtained to identify risk factors in the women and to review the management, communication, follow-up and outcome of pregnant women with syphilis. Standards were set against current BASHH guidelines on syphilis management and local standards. Results A total of 98 women were diagnosed with syphilis over the 5 years. 61% of all women were White British. 42/98 women were pregnant. 27% of non-pregnant women had infectious syphilis compared to 42% of pregnant women. 23% had another concurrent sexually transmitted disease. Most women were in a regular relationship with only 17 women reporting a casual partner in the last 3 months. Overall 41%, but only 7% of white British women, had had sex with a man from overseas. There were two cases of confirmed congenital syphilis and five early miscarriages. Documentation of excluded congenital syphilis was poor (only three cases) in GUM records. Conclusion The high level of infectious syphilis in pregnant women and poorly documented outcomes has informed a multi-disciplinary good practice arrangement to be produced and promoted to improve communication between clinicians, ensure recommended treatment and follow-up. No clear risk factor groups were found to inform repeat testing in later pregnancy. A new enhanced surveillance form is soon to be piloted which includes collecting data on birth outcomes.



An audit highlighting a lack of awareness of the UK national guidelines for HIV testing, 2008

December 2011

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14 Reads

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5 Citations

International Journal of STD & AIDS

Following the publication of the UK national guidelines for HIV testing 2008, we carried out a local audit to determine the level of awareness of these guidelines among doctors working in Sunderland Royal Hospital, Sunderland, UK. An email questionnaire was distributed. Over two-thirds of respondents were unaware of the publication of the guidelines. Only 36% of respondents felt comfortable in offering a patient testing for HIV. The majority of doctors who responded lacked knowledge and confidence in issues surrounding HIV management and diagnosis, suggesting that better dissemination of information and training is still needed.


Screening for alcohol use disorders in a genitourinary medicine setting

November 2011

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7 Reads

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4 Citations

International Journal of STD & AIDS

The new National Institute for Health and Clinical Excellence (NICE) guidance cites genitourinary (GU) medicine clinics as one setting where screening for alcohol-use disorders should be part of routine clinical practice. Northumberland GU medicine service has routinely used the Fast Alcohol Screening Tool (FAST) since June 2009. An audit of all first attendees to the service in April 2010 (n = 256) was carried out. This audit found that the FAST questionnaire was acceptable to both patients and staff (uptake of 95.7%). Statistically significant associations between excessive alcohol and higher rates of unprotected sex (P < 0.01), an increased number of sexual partners (P < 0.01) and higher rates of sexually transmitted infection (STI) diagnosis (P < 0.05) were also demonstrated.


Trichomonas vaginalis: An unusual presentation

September 2010

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29 Reads

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4 Citations

International Journal of STD & AIDS

We report a case of Trichomonas vaginalis (TV) presenting as vulval ulceration in a 41-year-old woman. There was complete resolution of her symptoms only after oral tinidazole. The delayed diagnosis and importance of using the correct tests for the diagnosis of TV are discussed.


Citations (4)


... 26,27 Although Brazilian services encourage this practice, 28 men's reluctance to participate in health services, including screening for and the treatment of STIs, results in a low uptake of services. 21,29,30 Besides the quality of services, socioeconomic factors are likely to play a role in the northeast region. Areas with social and income inequalities often have less access to a water supply and refuse collection services, inadequate sanitation and a disproportionally high population with low education. ...

Reference:

Spatiotemporal clustering, social vulnerability and risk of congenital syphilis in northeast Brazil: An ecological study
Preventing congenital syphilis - a regional audit of syphilis in pregnant women seen in Genitourinary Medicine services
  • Citing Article
  • November 2013

International Journal of STD & AIDS

... 1 In patients with CD, granulomatous lesions sometimes form in tissues distant to the gastrointestinal tract and this is referred to as metastatic CD. 2 Symptoms of metastatic CD are rare and can actually precede the classic symptoms of CD. 3,4 When this occurs, pediatricians and sub-specialists are often faced with diagnostic dilemmas and patients consequently suffer from prolonged symptoms and extraneous treatments. 5 In this article, we report the case of a pediatric patient who presented to dermatology for vulvar swelling and was ultimately diagnosed with metastatic CD. We also provide a brief review of the literature on similar cases and discuss the importance of maintaining a high index of suspicion for this presentation. ...

Vulval oedema: How many doctors does it take to make a diagnosis?
  • Citing Article
  • October 2013

European Journal of Obstetrics & Gynecology and Reproductive Biology

... Awareness of HIV testing guidelines in Europe is low. An audit from Sunderland, UK evaluating the implementation of the UK National HIV testing guidelines showed that over two-thirds of doctors were unaware of the publication of the guidelines [18]. Only one-third of physicians felt comfortable with offering a patient testing for HIV [18]. ...

An audit highlighting a lack of awareness of the UK national guidelines for HIV testing, 2008
  • Citing Article
  • December 2011

International Journal of STD & AIDS

... There are only three species of Trichomonas that can colonize human tissues: T. hominis, T. tenax and T. vaginalis. Only the latter one can cause disease being one of its very rare manifestations the appearance of painful ulcers on the genitals even in immunocompetent patients (10). None but T. tenax is an habitual commensal of oral cavity transmitted by direct contact and is considered to be non-pathogenic but it has been associated to periodontal disease (11). ...

Trichomonas vaginalis: An unusual presentation
  • Citing Article
  • September 2010

International Journal of STD & AIDS