Kritsana Phakanont's research while affiliated with Chulalongkorn University and other places
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Publication (1)
Dihydroorotase and dihydroorotate dehydrogenase, two enzymes of the pyrimidine biosynthetic pathway, were purified from Plasmodium berghei to apparent homogeneity. Orotate and a series of 5-substituted derivatives were found to inhibit competitively the purified enzymes from the malaria parasite. The order of effectiveness as inhibitors on pyrimidi...
Citations
... 5-fluoroorotate has been reported as an example of dihydroorotate dehydrogenase (DHODH) enzyme which involves in the final step of the pyrimidine biosynthetic pathway. This drug inhibited competitively the pyrimidine ring cleavage reaction for dihydroorotase and could lead to cure malaria completely (Fig. 22) [102]. Their results revealed that the inhibition on the pyrimidine synthetic pathway in the malarial parasite can be used for the design of potent antimalarial drugs. ...
