Jingyi Liu's research while affiliated with Third Military Medical University and other places
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Publications (3)
1,2:3,4-diepoxybutane (DEB) is a major carcinogenic metabolite of 1,3-butadiene (BD), which has been shown its potential genotoxicity to cause DNA strand breaks in cells. While the adverse effect of DEB on male reproductive cells in response to DNA damage has not been thoroughly studied and the related mechanism is yet to be elucidated. Using mouse...
1, 3-Butadiene (BD) is a high-efficiency carcinogen in rodents and was classified as a human carcinogen in 2008 by the International Agency for Research on Cancer. However, its ability to induce genetic damage and the influence of metabolic polymorphisms to such damage in humans are both controversial claims. This study was conducted to investigate...
In order to determine the potential toxicities of organic pollutants in the river water of Chongqing City (China), chemicals were extracted from surface water of the Yangtze River and Jialing River between August 2004 and January 2005. Gas chromatography/mass spectrometry (GC/MS) analysis showed that the main compounds detected were polycyclic arom...
Citations
... With regards to the observed effect of DEB on cell cycle regulation, our observations align with previous research that has revealed a dose-dependent upregulation of CCNB1 (CyclinB1) protein expression in mouse germ cells following DEB treatment [27]. Similarly, we observed significant increases in CCNB1 (CyclinB1) mRNA levels following treatment with 1.5 µM DEB in DU145 prostate cancer cells ( Figure 3B). ...
... The other group of Chinese researchers, the Cao and Ao group in the Department of Hygiene Toxicology of the Third Military Medical University, Chongqing, China, conducted a 1:1 matched pair study in a population of workers in a large petrochemical facility in Nanjing, China [165][166][167]. The workers were exposed to significantly higher levels of BD than did the control (5.02 vs. 1.86 mg/m 3 , p < 0.01), and exhibited elevated frequency of MN and nucleoplasmic bridge (NPB) (both p < 0.01) but lower nuclear division index (p < 0.01) in comparison to the control [165]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279123688738820-1443559681725_Q64/Wenbin-Liu-2.jpg)
... Induction of PAHs was also reported in the fish samples from the TGRA (Floehr et al., 2015a). Previously, the induction of cyp1a expression and the activation of aryl hydrocarbon receptor (AhR) signaling pathway were observed in H4IIE cells exposed to the sediment from the TGRA (Cui et al., 2009). ...
