Jingyao Zhao's research while affiliated with Chinese Academy of Sciences and other places
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Publications (10)
With the discovery of magnetoreceptor mechanisms in animals, it materialized the novel applications of controlling cell and animal behaviors using magnetic fields. T cells have shown to be sensitive to magnetic fields. Here, we reported that exposure to moderate SMFs (static magnetic fields) led to increased granule and cytokine secretion as well a...
In response to myeloablative stresses, HSCs are rapidly activated to replenish myeloid progenitors, while maintaining full potential of self-renewal to ensure life-long hematopoiesis. However, the key factors that orchestrate HSC activities during physiological stresses remain largely unknown. Here we report that Med23 controls the myeloid potentia...
Significance
Hematopoietic stem cells (HSCs) harbor the capacities of both self-renewal and differentiation to sustain life-long production of all blood cells. However, how individual HSCs accomplish the decision of self-renewal versus differentiation remains largely unknown. Here, we find that Uhrf1, a key epigenetic regulator of DNA methylation,...
Hematopoietic stem cells (HSCs) are responsible for the lifelong production of all blood cells. Although most adult HSCs are quiescent, fetal liver HSCs (FL-HSCs) are largely cycling and undergoing symmetric cell division, resulting in a net expansion of the HSC pool. This prenatal expansion is a prerequisite for FL-HSC maturation and colonization...
Citations
... 23 0.3 and 0.6 T SMFs enhanced the production of Granzyme B, IFN-γ and TNF-α in CD8 + T cells while promoting mitochondrial respiration to increase antitumor function. 24 Although studies have recognized the importance of the influence of SMF exposure on the immune system, research has yet to systematically explore its effect on B lymphocytes. B lymphocytes are essential for humoral immunity and play a crucial role in antibody secretion, antigen presentation, and immune regulation. ...
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... Thus, it was suggested tha t Media tor provides a Nucleic Acids Research, 2023 11 physical bridge between transcription activators at enhancers and the preinitiation complex at promoters ( 50 ), a role supported by recent short term knock-down studies and high resolution analysis of long range interactions ( 55 ). Pr evious co-immunopr ecipitation assays r e v ealed that IRF4 directly interacts with MED23 ( 56 ), which is the largest subunit in the tail module and is essential for early B cell de v elopment ( 57 ). To determine if MED23 is required for Ig activa tion, shRNA-media ted knockdown was performed, resulting in a dramatic reduction in MED23 protein le v els in cells e xpressing shRNA against MED23 (shMED23) compared to scrambled shRNA (shSCR; Supplementary Figure S3C, left). ...
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... In the present study, deletion of Uhrf2 resulted in an increased proportion of BM CMP cells, but not all other stem/progenitor fractions in BM. Considering that Uhrf1 deletion was reported to lead to erythroid-biased differentiation of HSCs [26], Uhrf2 might contribute to commitment of HSCs. However, the number of mature blood cells in peripheral blood was comparable between Uhrf2 −/− mice and Uhrf2 +/+ A B C ...
... 。LIS1 与磷酸化 DCX 结合， 调节神经突起的延伸及神经元迁移，维持神经元 移行过程的双极形态 [11] 。LIS1 信号通路又与细胞 存活、分裂、增殖及分化过程密切相关 [12][13][14] 。LIS1 信号通路的关键基因发生突变或缺失将导致严重 神经系统异常 [15][16][17][18][19][20][21][22][23] [12][13][14] 。Lis1 基因正常表 达是脑发育所必需的 [35][36][37] ，该基因异常将导致包 括平滑脑在内的严重神经系统畸形 [15][16][17][18][19][20][21][22][23] ...
