JC CEROTTINI's scientific contributions
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Publication (1)
Transplantation experiments have demonstrated that most mouse tumors express antigens that can constitute targets for rejection responses mediated by syngeneic T lymphocytes. For human tumors, autologous cultures mixing tumor cells and blood lymphocytes or tumor-infiltrating lymphocytes have produced CD8(+) and CD4(+) cytolytic T cell (CTL) clones...
Citations
... The collection and sequencing of the peptides exhibited by MHC class I molecules at the cell surface is a technique to discover antigens [127]. Copyright 2019, with permission from ACS recognized by CTL on the majority of HLA-A*02 melanomas, even though this is often employed to identify genes rather than peptides [123]. Predicted binding to MHC class I and the structural stability of the interacting peptide-MHC class I complex have both been used to identify peptide epitopes that promote tumor immunogenicity [124]. ...
Reference: Peptide-Based Therapeutics in Cancer Therapy