J. Perry Hall's scientific contributions
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It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
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Publication (1)
Metabolic reprogramming plays a central role in T cell activation and differentiation, and the inhibition of key metabolic pathways in activated T cells represents a logical approach for the development of new therapeutic agents for treating autoimmune diseases. The widely prescribed antidiabetic drug metformin and the glycolytic inhibitor 2-deoxyg...
Citations
... Hence, inhibition of glucose metabolism by metformin can also affect activities of other cells including immune cells (Nojima & Wada, 2023) and may modulate efficacy of metformin in clinical trials. In fact, earlier studies showed that metformin represses mitochondrial metabolism and T-cell-mediated immune response (Tan et al., 2020;Xu et al., 2021). However, cancer cells have been shown to reprogram several pathways other than glucose metabolism to harness energy as well as building blocks (Altman et al., 2016;De Berardinis & Chandel, 2016;Martínez-Reyes & Chandel, 2021;Yang & Vousden, 2016). ...
