J. Ellard's research while affiliated with La Trobe University and other places

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Publications (2)

Experience and psychological impact of anal cancer screening in gay, bisexual and other men who have sex with men: a qualitative study
Article
  • Jun 2017
Objective: Human papillomavirus (HPV)-related anal cancer rates are increasing and are particularly high in gay, bisexual and other men who have sex with men (GBM/MSM), especially HIV-positive individuals. Although screening programs for high-risk populations have been advocated, concerns about possible adverse psychological consequences exist. Th...
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Table 1 . Participant Characteristics a 
Figure 2. Positive responses detected by T-cell assays. Top panels...
Table 2 . Clinical Associations With Positive HPV-16 E6-Specific T-Cell...
Table 3 . Clinical Associations With Positive HPV-16 E7-Specific T-Cell...
Human Papillomavirus 16-Specific T-Cell Responses and Spontaneous Regression of Anal High-Grade Squamous Intraepithelial Lesions
Article
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  • Feb 2015
Background. Most anal cancers are attributable to persistent human papillomavirus type 16 (HPV-16) infection. The anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), frequently regresses spontaneously. We hypothesized that T-cell responses are associated with HSIL regression. Methods. In men who have sex with men undergoing an...
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Citations

... HPV subtypes differ in their genetic sequence and are categorized as low-risk or high-risk based on their oncogenic potential (4)(5)(6). Additionally, 14 HPV types are designated as human carcinogenic, including high-risk HPV (HR-HPV; HPV16, 18,31,33,35,39,45,51,52,56,58,59, and 68) (7,8). High-risk HPV strains, predominantly 16 and 18, are responsible for almost all cervical cancer cases. ...
Reference: An exploratory study of knowledge, attitudes, and practices toward HPV associated anal cancer among Pakistani population
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... Of particular importance may be the persistent depletion of CD4 + T cells from the mucosal compartments in PWH who have been treated during chronic infection (11,12), which may create a more favorable microenvironment for precancerous lesions to develop and progress. In this sense, altered cell-mediated immunity has been associated with increased HPV infection and disease (13), while immune responses orchestrate regression of HPV-related lesions (14). ...
Reference: Intraepithelial CD15 infiltration identifies high grade anal dysplasia in people with HIV
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