Hiroaki Manabe's research while affiliated with University of Texas Health Science Center at Houston and other places
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Publications (3)
Nearby cells within tissues communicate through ligand-receptor signaling interactions. Emerging spatial transcriptomic technologies provide a tremendous opportunity to systematically detect ligand-receptor signaling, but no method operates at cellular resolution in the spatial context. We developed CytoSignal to infer the locations and dynamics of...
The resting zone of the postnatal growth plate is organized by slow-cycling chondrocytes expressing parathyroid hormone-related protein (PTHrP), which include a subgroup of skeletal stem cells that contribute to the formation of columnar chondrocytes. The PTHrP-indian hedgehog (Ihh) feedback regulation is essential for sustaining growth plate activ...
Bone development starts with condensations of undifferentiated mesenchymal cells that set a framework for future bones within the primordium. In the endochondral pathway, mesenchymal cells inside the condensation differentiate into chondrocytes and perichondrial cells in a SOX9-dependent mechanism. However, the identity of mesenchymal cells outside...
Citations
... Prolonged chasing until P90 also revealed enlargement of columns in Ptch-cKO mice and demonstrated numerous cells in bone marrow originated from the labeled columns in both chasing periods (Supplemental Figure 3, C and D). The latter observation indicates that activation of the Hh pathway does not interfere with subsequent transdifferentiation, which aligns with a recent observation (18). ...
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... Recently, scRNA-seq analysis at the condensation stage using Prrx1-cre (E11.5 in mice) identified the presence of peri-condensation cells expressing Notch effector Hes1. These Hes1 + peri-condensation cells contribute to perichondrial cells and invade into the condensation to differentiate into chondrocytes within the cartilage template during the early embryonic stage, which has been demonstrated by in vivo lineage-tracing experiments using Hes1-creER (Fig. 2a) [61]. ...
