Hideaki Chiyo's scientific contributions

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Publications (1)

Nonrandom distribution of exchange points in patients with structural rearrangements
  • Article

February 1976

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6 Reads

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32 Citations

The American Journal of Human Genetics

Yasuo Nakagome

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Hideaki Chiyo

High resolution studies of structural rearrangements were carried out using the G-band technique. A total of 220 breakage points were identified within individual bands from 117 unrelated cases born with a structural rearrangement. Breakage points were not evenly distributed along chromosomes in terms of G-band patterns. There was an excess involvement of light bands and a striking lack of dark bands in both reciprocal translocations and inversions. In reciprocal translocations, the middle part of a chromosome arm has less chance of being the site of an exchange than the terminal and centromeric parts. The implications of these results are briefly discussed.

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Citations (1)

... Battisti et al. (2003) confirmed the hotspot on 18q21, leading to the speculation of the existence of clusters of breakage within specific bands. A non-random distribution of breakpoints in R-bands for structural chromosome rearrangements was postulated by Nakagome and Chiyo (1976). In the breakpoint FISH mapping of 152 apparently de novo balanced chromosomal rearrangements from patients with or without associated phenotype abnormalities, Fantes et al. (2008) observed the preferential location of breakpoints in R-bands, but they also indicated that the frequency of breakpoints disrupting genes was similar in the two study groups. ...

Reference:

Complex chromosomal rearrangements: Origin and meiotic behavior
Nonrandom distribution of exchange points in patients with structural rearrangements
  • Citing Article

  • February 1976

The American Journal of Human Genetics

Yasuo Nakagome

·

Hideaki Chiyo