Gang Liu's research while affiliated with Chongqing Medical University and other places
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Publications (31)
Objectives: Immune-responsive gene 1 (Irg1)-catalyzed production of itaconate is a bioactive metabolite with antibacterial, anti-inflammatory and antioxidant properties. Liver injury is closely related to poor outcomes in septic patients, while prevention of liver injury is essential for the pharmacological control of sepsis. This study investigate...
Background
Since there is a limited ability to identify the need for intubation in the ICU, the objective of this study was to develop and validate an interpretable machine learning (ML) model to predict the need for intubation in ICU patients.
Methods
Seven widely used ML algorithms were applied to develop and validate prediction models. Adult pa...
Accumulating evidence indicates that metabolic responses are deeply integrated into signal transduction, which provides novel opportunities for the metabolic control of various disorders. Recent studies suggest that itaconate, a highly concerned bioactive metabolite catalyzed by immune responsive gene 1 (IRG1), is profoundly involved in the regulat...
The rapid and accurate identification of methicillin-resistant Staphylococcus aureus at an early antibiotic therapy stage would be benefit to disease diagnosis and antibiotic selection. Herein, we integrated cross-priming amplification (CPA) and CRISPR/Cas 12a (designated as CPA-Cas 12a) systems to establish a sensitive and efficient lateral flow a...
Upregulation of pyruvate kinase M2 (PKM2) is critical for the orchestration of metabolism and inflammation in critical illness, while autophagic degradation is a recently revealed mechanism that counter-regulates PKM2. Accumulating evidence suggests that sirtuin 1 (SIRT1) function as a crucial regulator in autophagy. The present study investigated...
Background
Elevated resting heart rate (HR) predicts poor outcomes in patients with coronary artery disease. Ivabradine has been recommended as a second-line anti-anginal agent in chronic coronary syndrome, while there are no clear indications for acute ST-elevation myocardial infarction (STEMI).
Results
We systematically searched PubMed, Medline,...
Pheochromocytoma presents various clinical manifestations and imprecise signs and symptoms. Along with other diseases, it is considered to be ‘the great mimic’. This is the case of a 61-year-old man who on arrival presented with extreme chest pain accompanied by palpitations, and with a blood pressure of 91/65 mmHg. An echocardiogram showed an ST-s...
Background: Imbalance of testosterone/estradiol ratio are frequently reported to be associated with the risk of cardiometabolic diseases; however, studies have yet to report the testosterone/estradiol ratio and its relationship to cardiometabolic diseases in women at menopause transition. This study aimed to explore the association between testoste...
Itaconate, produced by aconitate decarboxylase 1 (ACOD1) which is encoded by immune-responsive gene 1 (Irg1), is one of the metabolites derived from the tricarboxylic acid cycle. It has been reported that exogenous itaconate plays an anti-inflammatory role in the progression of multiple diseases, including activated macrophage, ischemia-reperfusion...
Rev-Erbα is a nuclear heme receptor, transcriptional repressor, and critical component of the molecular clock that drives daily rhythms of metabolism. However, the roles of Rev-Erbα in acute lung injury (ALI) remain unclarified. Hence, the effect of Rev-Erbα on lung injury of sepsis mice is investigated here. The mice sepsis model is established us...
Hepatic ischemia-reperfusion injury (HIRI) is a serious situation with high morbidity and mortality, which is usually accompanied with hyperlactatemia due to impaired lactate clearance in liver. G-protein-coupled receptor 81 (GPR81) has recently been identified as the bioactive receptor of lactate. GPR81 is profoundly involved in the modulation of...
The 2016 European Society of Cardiology Guidelines introduced a new term, mid-range left ventricular ejection fraction (mrEF) heart failure, however, the clinical characteristics and short-term outcomes in cardiogenic shock patients with mrEF after acute myocardial infarction remain unclear. This retrospective study analyzed the baseline characteri...
Background
Lung cancer associated with cystic airspaces, especially solitary multicystic lesion lung cancer, is a rare disease (a rare imaging performance of non-small cell lung cancer). It is difficult to diagnose owing to the lack of a clear definition; therefore, diagnosis of these neoplastic lesions remains challenging.
Case presentation
We ou...
Background:
Patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI) are at high risk of death. Inflammation is involved in both CS and AMI, and our present study aimed to investigate the changes of leukocyte and its subtypes as well as their prognostic value in patients with CS complicating AMI.
Methods:
Data of 217 c...
Fas-induced apoptosis is a central mechanism of hepatocyte damage during acute and chronic hepatic disorders. Increasing evidence suggests that circadian clock plays critical roles in the regulation of cell fates. In the present study, the potential significance of REV-ERBα, a core ingredient of circadian clock, in Fas-induced acute liver injury ha...
Background
Previous studies have shown elevated admission heart rate (HR) was associated with worse outcome in patients with myocardial infarction (MI). However, the prognostic value of mean heart rate (MHR) with Holter monitoring remains unclear.
Objectives
Our present study aims to evaluate the impact of MHR by Holter monitoring on long-term mor...
![Relationships between lipoprotein (a) [Lp(a)] and atherosclerotic...](publication/352403342/figure/fig2/AS:11431281187167507@1694146960192/Relationships-between-lipoprotein-a-Lpa-and-atherosclerotic-burden-A-Association_Q320.jpg)
Background: The coronary atherosclerotic burden in patients with ST-segment elevation myocardial infarction (STEMI) has been identified as the main predictor of prognosis. However, the association of lipoprotein(a) [Lp(a)], a well-established proatherogenic factor, with atherosclerotic burden in patients with STEMI is unclear.
Methods: In total, 1,...
Elevated resting heart rate in chronic heart failure (HF) patients has been associated with higher mortality and poor prognosis. Ivabradine is a new pure bradycardic agent that has been used to treat angina or heart failure reduced ejection fraction (HFrEF) with sinus heart rate above 70 beats per minute. However, the effect of ivabradine for chron...
Objective
High-fat diet is one of the main risk factors that disrupt the balance of gut microbiota, which eventually will induce colorectal cancer (CRC). Evodiamine (EVO) is a wildly used multifunctional traditional Chinese medicine extract. In this study, we investigated the role of gut microbiota in high-fat diet-propelled CRC and the potential o...
Object:
The relationship between PR interval prolongation during hospitalization and long-term prognosis in patients with acute ST-segment elevation myocardial infarction (STEMI) has not been elucidated. This study aimed to evaluate the prevalence, predictors, and outcomes of PR interval prolongation in a prospective cohort of patients with post-S...
Iron-based porphyrinic metal-organic frameworks (PMOFs) are desirable for biomimetic applications, due to the low toxicity and high abundance of Fe as well as the rich biomimetic functions of metalloporphyrins. Besides, the uniform dispersion of porphyrin centers in PMOFs can effectively prevent them from self-dimerization. Nevertheless, it remains...
Background:
Previous studies had demonstrated hemostatic abnormalities in patients with heart failure (HF) and several studies have shown that abnormal coagulation indices, represented by elevated D-dimer, had prognostic significance in patients with compatible or acute decompensated HF. However, the impact of D-dimer on the outcome in patients wi...
In acute ST-segment elevation myocardial infarction (ASTEMI), new-onset atrial fibrillation (NOAF) was not only associated with worse short-term outcomes but also with higher long-term mortality. This study aimed to evaluate the effect of dyslipidemia on the incidence of NOAF. Among the 985 patients (2014 to 2017) with ASTEMI consecutively enrolled...
An uncontrolled inflammation induced critical health problems with serious morbidity and death, which namely acute lung injury (ALI). Recently research have found the anti-inflammatory effects of emodin. Here, we investigated the potential effects of emodin on a mouse model with a lethal dose of the potential mechanisms and lipopolysaccharide (LPS)...
AMP-activated protein kinase (AMPK) is a crucial metabolic regulator with profound modulatory activities on inflammation. Although the anti-inflammatory benefits of AMPK activators were well documented in experimental studies, the pathological significance of endogenous AMPK in inflammatory disorders largely remains unknown. This study investigated...
The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K), with hydrogen‑rich saline on the proliferation and apoptosis of the non‑small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this. Excessive production of reactive oxy...
A new metal-organic aerogel (MOA-Rh-2) containing dirhodium paddle-wheels has been prepared from the reaction of dirhodium(II) tetracarboxylate (Rh2(OAc)4) and tetrakis(4-carboxyphenyl)porphyrin (TCPP) in a mixed solvent of DMF and water, followed by supercritical CO2 extraction. MOA-Rh-2 has been fully characterized by ICP-OES, EDS, XPS, PXRD, SEM...
Objectives:
The purpose of this study was to assess the association of the age at menarche with obesity and hypertension among southwestern Chinese women.
Methods:
Participants in a cross-sectional study were required to recall and complete a standard self-reporting questionnaire, including age at menarche and lifestyle habits. Cardiovascular ri...
Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals with myocardial infarction and...
The aim of this study was to investigate the association between alcohol intake and left ventricular mass (LVM) independent of the effects of blood pressure and other factors in rural areas of Western China. The present study included 1007 subjects (487 men and 520 women) aged ≥35 years from the Tongan district, Chongqing, China. The quantity and f...
In this research, a novel electrochemical immunosensor for competitive detection of pregnancy-associated plasma protein-A (PAPP-A) in serum had been successfully developed. The PAPP-A was covalently immobilized on the glass carbon electrode (GCE) modified with functional single walled carbon nanotubes/chitosan (SWNTs/CS) to amplify signal. After th...
Citations
... This method has been shown to be safe, rapid, simple, and cost-effective approaches for virus detection Mao et al. 2022;Sun et al. 2021;Xiong et al. 2020). Furthermore, it is known for low single base mismatch rate, and minimal instrument requirements compared to other detection methods (Gong et al. 2021;Wu et al. 2023). These studies prompted us to test whether CRISPR-Cas system can also be utilized for the detection of SECoVs. ...
... A large meta-analysis confirmed the sexdependent association of total testosterone (TT) and free testosterone with MS while a sex-independent association between sex hormone-binding globulin (SHBG) and MS (14). Recently, some studies highlighted a balance between TT to estradiol (E) is critical for CVD risk evaluation in men or women (15)(16)(17)(18)(19)(20)(21)(22). Limited studies also evaluated a ratio of TT to SHBG or E to SHBG as a marker for CVD risk (23)(24)(25)(26)(27). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1058331372302336-1629337270152_Q64/Samuel-Obiegbusi.jpg)
... Then genes associated with NF-κB and STAT signaling pathways could be further downregulated in LPStreated macrophages [153]. In addition, in endotoxemia-induced ALI, IRG1 or itaconate also alleviated pathological injury by decreasing inflammatory effect and ferroptosis through activating NRF2 and enhancing autophagy [154,155]. Taken together, itaconate serves as a key immunometabolite with various roles in inflammation and immunity, which may be an endogenous drug against ALI. ...
... 31,33 In addition, GPR81 activation alleviated DSS-induced colitis but promoted hepatic ischemia-reperfusion injury induced lung injury. 34,35 Therefore, the effect of GPR81 activation might depend on cell-specific or damage type. ...
... The number of deaths is estimated to increase to more than 23.6 million by 2030 [2]. Acute myocardial infarction (AMI), as a serious cardiovascular disease, is the main cause of cardiogenic shock, accounting for more than 80% [3]. In clinical practice, percutaneous transluminal angioplasty, thrombolysis and beta-blockers, angiotensin-converting enzyme inhibitors, aldosterone antagonists and angiotensin II (Ang II) receptor antagonists are mostly used. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281131519461-1680152493469_Q64/Yuansong-Zhu.jpg)
... In cases of cystic lung cancer, which is relatively common compared to IMT, the etiology of cystic lesions varies with multiple hypotheses [15]. Based on this report, the expansion of the cavitary lesion is most likely due to the tumor directly destruction of pulmonary alveoli. ...
... An important mechanism of hepatocyte damage during acute and chronic hepatic diseases, such as virusdriven hepatitis, ALD, NAFLD, and ischemia/reperfusion (I/R)-induced liver injury, is the aberrant activation of apoptosis by Fas (a death receptor also known as CD95). Fortunately, treatment with GSK4112 improves liver damage caused by Fas in mice [67]. Mechanistically, GSK4112 reduces Fas levels, enhances Akt phosphorylation, and lowers caspase-3 and caspase-8 activity, thereby inhibiting hepatocyte apoptosis and ameliorating liver injury. ...
... Bae et al. (2014) demonstrated the value of PDW as a diagnostic tool to predict AMI. Sasmita et al. (2022) emphasized the importance of basophil count as a prognostic factor for detecting AMI. Liu et al. (2022) determined the importance of RDW-CV counts in patients with AMI. ...
... Over the last 10 years, genetic and epidemiologic evidence supported that high Lp(a) level was a risk factor for cardiovascular disease [3][4][5][6]. Moreover, previous studies, including the present authors, revealed that Lp(a) was positively associated with recurrent cardiovascular events in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) [7][8][9][10]. However, there are no approved pharmacologic therapies that are specifically aimed at lowering Lp(a) levels. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/895790897692672-1590584601008_Q64/Yuzhou-Xue.jpg)
... Ivabradine should be considered for treating HFrEF with a sinus rhythm of 70 bpm on a maximum dose of beta blockers, or when beta blockers are contraindicated [4,5]. The impact of ivabradine on the incidence of bradycardia has not been widely reported [12]. Additionally, ivabradine has been reported to be linked to increased atrial fibrillation (AF) risk [13,14]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/445912410529792-1483325211212_Q64/Yuan-Yang-23.jpg)
