Elizabeth Martin's research while affiliated with Johns Hopkins University and other places

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Publication (1)

Differential Regulation of Small Heat Shock Proteins in Transgenic Mouse Models of Neurodegenerative Diseases
Article
  • May 2008
Previously, several studies have demonstrated changes in the levels of small heat shock proteins (sHSP) in the transgenic mouse models of familial amyotrophic lateral sclerosis (fALS) linked to mutations in Cu/Zn superoxide dismutase. Here, we compared the expression of sHSPs in transgenic mouse models of fALS, Parkinson's disease (PD), dentato-rub...
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Citations

... This result is in favor of a contribution of this gene to a reduction in neuronal survival in vivo. HSPD1 expression was not significantly decreased, which is consistent with previous observations in a mouse model of ALS and PD [156,157]. Nicotinamide phosphoribosyltransferase (NAMPT) is a catalyzer of nicotinamide adenine dinucleotide (NAD). Decreased levels of NAD, a cofactor in numerous redox reactions, have been observed in the aging brain and are closely associated with classical ALS and PD progression [75]. ...
Reference: Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes
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