ELZ-BIETA KOZŁOWSKA's scientific contributions
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Publication (1)
Background Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives Th...
Citations
... PAM merupakan bagian penting dari sistem imun alamiah dimana klasifikasinya dapat didasari dari muatan listrik, fungsi, aktivitas, dan karakteristik struktur tiga dimensinya. [13][14][15][16]18,19 Cathelicidin Cathelicidin dikenal sebagai peptida anti mikrobial dengan karakteristik terbaik dan secara umum disimpan pada sejumlah sel imun innate tubuh diantaranya pada Natural Killer Lymphocytes (NK), neutrofil, makrofag, sel epitel pada saluran cerna, genitalia, lapisan mata dan kelenjar endokrin sebagai respon atas proses infeksi atau inflamasi, kerusakan pada sel epitel maupun radiasi sinar UV. [20][21][22][23][24][25] Cathelicidin memiliki aktivitas anti patogen yang kuat dan berperan sebagai immunomodulator spektrum luas. Cathelicidin secara rutin diekskresikan tubuh melalui jalur sinyal vitamin D namun ekspresinya dapat dipengaruhi proses infeksi atau inflamasi. ...