D R Storms's research while affiliated with University of Washington Seattle and other places
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Publication (1)
The type I adenylyl cyclase is directly stimulated by Ca2+ and calmodulin in vitro, and the enzyme is also stimulated by increases in intracellular Ca2+ in vivo. Ca2+ stimulation of the enzyme in vivo may be due to direct interactions of the enzyme with Ca2+ and calmodulin or to an indirect mechanism involving stimulation of the enzyme by Ca(2+)-ac...
Citations
... The function of different isoforms of AC is directly dependent on the concentrations of intracellular Ca 2+ ; AC I (K d = 100 nM) (14) and AC VIII (K d = 500 nM) (15) are Ca 2+ -activated isoforms, while physiological concentrations of Ca 2+ inhibit AC V-VI (16). The genetic diversity suggests that different isoforms may serve distinct functions in specific regions of the body. ...
