Colleen C. Nackerman's research while affiliated with The Ohio State University and other places
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Publications (2)
The pore-forming toxin listeriolysin O (LLO) is a major virulence factor secreted by the facultative intracellular pathogen Listeria monocytogenes. This toxin facilitates L. monocytogenes intracellular survival in macrophages and diverse nonphagocytic cells by disrupting the internalization vesicle, releasing the bacterium into its replicative nich...
Citations
... LLO (58 kDa) was the first identified virulence factor of L. monocytogenes (Harvey and Faber, 1941;Gaillard et al., 1986;Geoffroy et al., 1987;Cossart et al., 1989). The main function of the LLO is to participate in the lysis of the phagocytic vacuole and the release of L. monocytogenes into the host cytoplasm (Arnett et al., 2014) (Figure 1). During spread to neighboring cells, L. monocytogenes is enclosed in a secondary vacuole ( Figure 1) and then released by LLO to the host cytoplasm (Osborne and Brumell, 2017). ...