Chin-Shoou Lin's research while affiliated with Georgetown University and other places
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Publications (10)
This report describes a new finding regarding language-Supplementary Motor Area (SMA) in language processing using robust clinical protocols i.e. word generation (WG) and sentence generation (SG). This is a retrospective study on 7 patients referred for fMRI for preoperative language mapping. Subjects ranged in age from 20 - 40 years (28.8 ± 7.3),...
The peripheral-type benzodiazepine receptor (PBR) is an 18-kDa high affinity drug- and cholesterol-binding protein that is involved in various cell functions, including cell proliferation and apoptosis. PBR was shown to be overexpressed in certain types of malignant human tumors and cancer cell lines, correlating with enhanced tumorigenicity and ce...
In three healthy gravidas at 38 and 39 weeks gestation, fetal MR spectroscopy was performed with a breath-hold technique by using the following pulse sequences: single voxel point-resolved spectroscopy, or PRESS, for liver and heart studies and stimulated-echo acquisition mode, or STEAM, for brain studies. Signal peaks of lipid from heart and liver...
Functional magnetic resonance imaging (fMRI) studies have demonstrated localized brain activation during cognitive tasks. Brain activation increases with task complexity and decreases with familiarity. This study investigates how sleepiness alters the relationship between brain activation and task familiarity. We hypothesize that sleepiness prevent...
Proton magnetic resonance spectroscopy is a noninvasive technique that detects molecules within a specified region in vivo. Lecithin, the major component of surfactant, has a characteristic magnetic resonance signal, but to our knowledge, it has never been reported in fetal lung or amniotic fluid (AF). The objective of this study was to characteriz...
This report focuses on proton magnetic resonance spectroscopy (1H MRS) of spine vertebra acquired with two-dimensional chemical shift imaging (2D CSI), utilizing the stimulated echo acquisition mode (STEAM) sequence. Both validity and reproducibility studies were performed. To validate the 2D CSI method, its spectra were compared with those obtaine...
The prenatal determination of fetal lung maturity is currently assessed by chemical analysis of surfactant associated lipids from amniotic fluid obtained by amniocentesis. This is an invasive procedure with rare but occasionally serious morbidity. Magnetic resonance spectroscopy (MRS) is a non-invasive method for the in vivo localization and identi...
The construction of two novel mult-segment (MS) resonators are described. The signal-to-noise ratio (SNR) and B1 homogeneity of the coils are compared with that of a surface coil and a standard quadrature head coil. The images obtained with the MS designs revealed a surface coil-like fall-off in signal with depth. The SNR offered by MS coils was fo...
This report describes a novel localization method for fMRI brain mapping and a new finding of fMRI activation of the premotor area (PMA) during visually stimulated word and sentence generation and verbally stimulated word generation. These tasks constitute challenging, covert, and internally cued language tasks. This is a retrospective study on sev...
Citations
... However, cortical activity during language tasks as assessed by fMRI is not limited to these two areas. Foci of fMRI activation are intriguing to many basic neuroscientists, as they can also be demonstrated in the premotor area (PMA) [1][2][3][4][5][6] , the language-supplementary motor area (L-SMA) 7 the supplementary motor area (SMA) 5,[8][9][10][11] , the cerebellum 9,12 , basal ganglia 12 , and cingulate gyrus 9,13 , but the relevance of such activation is not as well understood or consistently described. ...
... Theory predicts that phased arrays perform better in signal-to-noise ratio (SNR) terms than single coils, without sensitivity losses at larger distances (1). Nevertheless, signal cancellations (2) or no substantial SNR improvements with increasing number of coil elements at the center of multichannel coils have also been observed (3). ...
... The amount of choline could correlate with the amount of surfactant in lung (25,26). Unfortunately, this technique has various limitations, especially motion artifacts. ...
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... For example, 1D PRESS spectroscopy (1D-MRSI) has been used to selectively excite signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra (Edden et al., 2007). Two-dimensional (2D)-MRSI of water and lipids in the spinal cord has been described (Lin et al., 2000), but so far no study has been published with water-suppressed 2D-MRSI as is needed for detection and quantification of metabolites. Recent developments at higher field strength (3 T) indicate the possibility to detect additional metabolite concentrations with spinal cord MRS, such as the glutamate/glutamine (Solanky ISMRM 2012). ...
... Most data related to this subject matter were obtained in preterm studies, but these findings do not reflect physiological maturation process during normal pregnancy [8,9]. Proton magnetic resonance spectroscopy ( 1 H MRS) is a useful tool for obtaining information on human brain metabolism [1][2][3][4][5]11,12]. This non-invasive technique is employed in a large number of studies investigating the development and aging of the human brain, but these mainly focus on the period from childhood to old age [8]. ...
... Numerous studies have examined alterations in neuronal activity associated with transitions from wakefulness to sleep under anesthesia, during resting state, or following explicit instructions to try to fall asleep (Chang et al., 2016;Fransson, 2005;Horovitz et al., 2008;Larson-Prior et al., 2009;Poudel, Innes, Bones, Watts, & Jones, 2014;Starbuck, Kay, Platenberg, Lin, & Zielinski, 2000;Tagliazucchi & Laufs, 2014). Presently, no neuroimaging data exists on the MSLT or the MWT to examine neurological correlates of the ability to maintain wakefulness or induce sleep while rested or under conditions of sleep loss. ...
... It directly inhibits aromatase activity and expression, thereby reducing estrogen production in estrogen-sensitive breast cancer cells (Park et al., 2016). Additionally, EGb 761 downregulates peripheral-type benzodiazepine receptor (PBR) expression in diverse cancer cell lines, which may suppress cancer aggressiveness and invasiveness (Pretner et al., 2006). In vivo studies confirm its ability to reduce tumor growth in mouse xenograft models of breast cancer. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281118352740-1675730991419_Q64/Vassilios-Papadopoulos.jpg)
