C. Rodrigues's research while affiliated with P.D Hinduja National Hospital & Medical Research Centre and other places

... This shows that there was a high agreement between mCIM and Xpert Carba-R in the detection of carbapenemase enzyme. This finding is correlating with the results of previous studies by Patel [20,27]. These findings conclude that though mCIM test has a longer turnaround time due to overnight incubation, mCIM is suitable for a resource-poor microbiology laboratory as it is inexpensive, easy to perform, less subjective with a more reliable sensitivity compared to CarbaNP test. ...

... From blood cultures samples, frequencies of resistance, such as of Pseudomonas aeruginosa to piperacillin-tazobactam (33.0% vs 18.3%), were also higher [7] . In a systematic review and meta-analysis about global prevalence of nosocomial infection was conducted a comprehensive search of electronic databases including EMBASE, Scopus, PubMed and Web of Science between 2000 and June 2021. ...

... The selection of clofazimine-resistant M. tuberculosis isolates has been demonstrated in vitro (Hartkoorn et al., 2014) and reported in clinical isolates (Xu et al., 2017;Nimmo et al., 2020a). The MIC distribution of clofazimine in mycobacterial growth indicator tube (MGIT) culture systems ranges between 0.125 µg/mL-0.5 μg/mL for pan-susceptible and 0.25 µg/mL-1 µg/mL for DR-TB strains (Ismail et al., 2019), with a critical concentration of 1 μg/mL recommended by the WHO (World Health Organistation, 2018). Reliable estimates of the prevalence of clofazimine resistance are not available. ...

... However, this relies on the accurate identification of pathogenic microorganisms and AMR. Different methods are available for AMR detection or prediction, ranging from traditional (gold standard) culture-based techniques to PCR-based molecular detection and, more recently, sequencing-based methods [3,4]. The gold standard phenotypic susceptibility testing (PST), which requires positive culture growth before conducting drug susceptibility testing, is typically time-consuming [5]. ...

... a Healthy human serum; b healthy bovine serum and prone to cross-contamination, which also limits its application in certain regions (Kunnath-Velayudhan et al. 2012;Mukamolova et al. 2010). In vitro isolation of MTB is considered the "gold standard" for the diagnosis of pulmonary and extrapulmonary tuberculosis, with a high detection rate and strain identification, but these methods have limited sensitivity and specificity, are time-consuming (6-8 weeks), and are not very useful for early diagnosis (Nambiar et al. 2017;Pai et al. 2014). The TB PPD skin test is a commonly used clinical immunological test that is used for the detection of TB due to its simplicity and speed, but it cannot clearly distinguish between BCG immunization and pathogenic MTB infection, has low differential diagnostic value, and is prone to high false-positive and false-negative results (Mosavari et al. 2021). ...

... 34 The predilection towards women in EPTB cases could be attributed to self-neglect towards health and later presentation of active TB as EPTB. [36][37][38] According to the WHO global TB report, the prevalence of MDR-TB in new and previously treated cases was 2.5-2.8% and 14-17%, respectively. 39 As a high TB burden country, India is also a hotspot region for MDR-TB infection. ...

... The global spread of carbapenem-resistant Enterobacterales (CRE) represents a serious public health concern as these pathogens are associated with limited treatment options, high mortality rate and rapid transmissibility (1,2). Mechanisms underlying carbapenem resistance are related mainly to the production of carbapenemases (carbapenemase-producing Enterobacterales, CP-CRE), but also a consequence of decreased membrane permeability coupled with the overexpression of extended-spectrum β-lactamases (ESBLs) or AmpC β-lactamases (non-carbapenemase-producing carbapenem-resistant Enterobacterales, non-CP-CRE) (3)(4)(5). ...

... Incomplete eradication of tuberculosis during medical treatment allows pathogens to remain in the patients. This remaining bacterial population can result in refractory tuberculosis (Davies, 2001), where genetic mutation-conferred drug resistance may play a part, but bacterial persistence is believed to be the primary cause (Wayne, 1994). Many persisters are found in a microenvironment known as a granuloma (Davies, 2001;Honer Zu Bentrup & Russell, 2001), which creates difficult conditions such as high oxidative stress, low pH, and limited nutrients that induce persister formation (Davies, 2001;Honer Zu Bentrup & Russell, 2001;Marakalala et al., 2016;Mok et al., 2015;Rubin, 2009). ...

... In 1996, the private, not-for-profit Hinduja Hospital in South Mumbai published data on its TB patients, of which 32% had MDR-TB and 8% were XDR-TB cases. This created quite a debate among public health experts in India (Udwadia et al. 1996;Udwadia 2001). The mycobacterial laboratory serves as a reference laboratory for Mumbai and reported in 2001 that around 60% of all isolates it receives are MDR-TB (Udwadia 2001). ...

... Soman et al., 2015, reported a series of five cases of coronary stent infection caused by rapidly growing mycobacteria (RGM), which lead to infective endocarditis. Four out of five patients died due to complications of infective endocarditis, and the reuse of balloon angioplasty catheters was thought to be the plausible cause behind this complication [10]. Formation of coronary-cameral fistula secondary to coronary stent infection has also been reported [11]. ...