Bruna R. de Queiroz's research while affiliated with Université Côte d'Azur and other places

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Publication (1)

RNA granules in neuronal plasticity and disease
Article
  • May 2023
RNA granules are dynamic entities controlling the spatiotemporal distribution and translation of RNA molecules. In neurons, a variety of RNA granules exist both in the soma and in cellular processes. They contain transcripts encoding signaling and synaptic proteins as well as RNA-binding proteins causally linked to several neurological disorders. I...
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Citations

... A loss-of-function mutation of the FMR1 gene that encodes FMRP causes Fragile X Syndrome, the most frequently inherited form of intellectual disability and the most prevalent monogenic cause of autism (Bassell and Warren, 2008;Bagni and Zukin, 2019). Under basal conditions, FMRP binds ribosomes and mRNAs to form an FMRP granule; and in this bound state, mRNA translation is repressed (Bauer et al., 2023). Activity leads to FMRP dephosphorylation, which triggers granule disassembly and de-repression of translation. ...
Reference: Presynaptic Protein Synthesis in Brain Function and Disease
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