Bing Guo's research while affiliated with Guizhou University and other places
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Publications (113)
Obesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autophagy regulates lipid mobilization to maintain energy balance. TIGAR (Trp53 induced glycolysis regulatory phosphatase) has been identified as a glycolysis...
Rationale: Primordial follicles are limited in number and cannot be regenerated, dormant primordial follicles cannot be reversed once they enter a growth state. Therefore, the length of the female reproductive lifespan depends on the orderly progression and selective activation of primordial follicles, the mechanism of which remains unclear.
Method...
Four series of novel 1,3,4‐oxadiazole/1,2,4‐triazole hybrids of phthalide derivatives were designed and synthesized to search for novel potential antifungal agents. Preliminary antifungal activity assay results showed that compounds 4 a , 4 b , 4 m , 5 b , 5 f , 5 h , and 7 h exhibited moderate to excellent inhibitory activity against some phytopat...
Current diagnostic methods for diabetic nephropathy (DN) lack precision, especially in early stages and monitoring progression. This study aims to find potential biomarkers for DN progression and evaluate their accuracy. Using serum samples from healthy controls (NC), diabetic patients (DM), early-medium stage DN (DN-EM), and late-stage DN (DN-L),...
Diabetic kidney disease (DKD) is the main cause of death due to diabetes mellitus (DM). Due to the complexity of the onset, it is difficult to achieve accurate prevention and treatment. The classically activated macrophages (M1) polarization is a crucial proinflammatory mechanism in DKD, while the interaction and cascade effects of oxidative stress...
Herein, the use of triphenylmethylium tetrakis(pentafluorophenyl)borate as an efficient catalyst for the intermolecular dehydrative coupling of p‐hydroxymandelic acid hydrate with substituted aromatic amines and (thio)phenols was developed, which allows for the preparation of aryl acetic acid derivatives in a convenient manner. Notably, this method...
Unprogrammed macrophage polarization, especially prolonged activation of proinflammatory macrophages, is associated with delayed wound healing in diabetic objectives. Macrophage-derived exosomes cargo a variety of microRNAs (miRNAs), participating in different stages in wound healing. Here, exosomes were isolated from naive bone marrow–derived macr...
To discover novel and effective potential agricultural antifungal agents, various kinds of imidazo[1,2-a]quinoxaline derivatives were designed, and synthesized from available and inexpensive reagents. Their antifungal activities were first evaluated against ten typical phytopathogenic fungi. The in vitro antifungal activity showed that some compoun...
The G-rich DNA, such as telomere, tends to form G-quadruplex (G4) structure, which slows down the replication fork progression, induces replication stress, and becomes the chromosome fragile sites. Here we described a molecular strategy that cells developed to overcome the DNA replication stress via DNA helicase regulation.
The p53N236S (p53S) muta...
Three previously undescribed diterpenoids, helioscopnoids A–C, and eight known compounds were isolated from the whole plants of Euphorbia helioscopia . Their structures were established by extensive analysis of spectra and data comparison with previous literatures. Among them, compound 4 was identified as 24,24‐dimethoxy‐25,26,27‐trinoreuphan‐3 β ‐...
Impaired wound healing and ulcer complications are major causes of morbidity in patients with diabetes. Impaired wound healing is associated with increased inflammation and poor angiogenesis in diabetes patients. Here, we demonstrate that topical administration of a secreted recombinant protein (Meteorin-like [Metrnl]) accelerates wound epitheliali...
As an essential factor in the prognosis of systemic lupus erythematosus (SLE), lupus nephritis (LN) can accelerate the rate at which patients with SLE can transition to chronic kidney disease or even end-stage renal disease. Podocytes now appear to be a possible direct target in LN in addition to being prone to collateral damage from glomerular cap...
The abnormal activation of the mTOR pathway is closely related to the occurrence and progression of cancer, especially colorectal cancer. In this study, a rational virtual screening strategy has been established and MT-5, a novel mTOR inhibitor with a quinoline scaffold, was obtained from the ChemDiv database. MT-5 showed potent kinase inhibitory a...
The fidelity of alternative splicing (AS) patterns is essential for growth development and cell fate determination. However, the scope of the molecular switches that regulate AS remains largely unexplored. Here we show that MEN1 is a previously unknown splicing regulatory factor. MEN1 deletion resulted in reprogramming of AS patterns in mouse lung...
Ten previously undescribed sesquiterpenes, carpespenes A-J (1-10), and eight known compounds (11-18), were isolated from the whole plants of Carpesium faberi. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Carpespene A (1) is eudesmanolide-type sesquiterpene lactone with an open five membered ring involvin...
SET and MYND domain protein 2 (SMYD2) can methylate histone H3 at lysine36 (H3K36) and some non-histone substrates to play a role in tumorigenesis. However, It is unclear how SMYD2 contributes to chronic kidney disease (CKD). Here, AZ505 or LLY507, which could inhibit SMYD2, were used in cisplatin-induced CKD to investigate the effects and possible...
Rheumatoid arthritis (RA) is a chronic autoimmune disease triggered by a cascading inflammatory response. Sigesbeckia Herba (SH) has long been utilized as a traditional remedy to alleviate symptoms associated with rheumatism. Our previous study found that leocarpinolide B (LB), a sesquiterpene lactone isolated from the whole plant of SH, possesses...
Background
The Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to the complicity of the components, the pharmacological mechanism of Bazhen decoction is still limited.
Methods
We applied RNA sequencing and transcriptome analysis to get the full view of the signaling...
Protoporphyrinogen oxidase (PPO) is a key enzyme in chlorophyll and heme biosynthesis, and the development of its inhibitors is of great importance both in the pharmaceutical and pesticide industries. However, the currently developed PPO inhibitors have insignificant bio-selectivity and have a serious impact on non-target organisms. In this study,...
Background and Purpose: The Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to the complicity of the components, the pharmacological mechanism of Bazhen decoction is still limited. Experimental approach: We applied RNA sequencing and transcriptome analysis to get the...
Impaired protein N-glycosylation leads to the endoplasmic reticulum (ER) stress, which triggers adaptive survival or maladaptive apoptosis in renal tubules in diabetic kidney disease (DKD). Therapeutic strategies targeting ER stress are promising for the treatment of DKD. Here, we report a previously unappreciated role played by ENTPD5 in alleviati...
Herein, a protecting-group-free protocol was developed to realize a time and step economy diversification of the Meridianin alkaloid. A broad range of substituents are tolerated to deliver the products in moderate to high yields, and the first synthesis of Meridianin B was achieved. The simplicity of this protocol enables the rapid construction of...
Ectopic lipid accumulation in renal tubules is closely related to the pathogenesis of diabetic kidney disease (DKD), and mitochondrial dysfunction is thought to play a key role in lipid accumulation. Therefore, maintaining mitochondrial homeostasis holds considerable promise as a therapeutic strategy for the treatment of DKD. Here, we report that t...
Phthalide, benzoxazole, and chromene are important heterocyclic skeletons with extensive biological activities. In order to develop novel potential antifungal agents, twenty-two benzoxazole/chromene-containing phthalide derivatives were prepared, and their fungicidal activity against nine common plants pathogenic fungi were evaluated in vitro. The...
Diabetic kidney disease (DKD) is one of the most serious complications of diabetes mellitus (DM) and the main cause of end‐stage renal failure. However, the pathogenesis of DKD is complicated. In this study, we found that miR‐124‐3p plays a key role in regulating renal mitochondrial function and explored its possible mechanism in DKD progression by...
Renal interstitial fibrosis (RIF) is a common pathological hallmark of progressive chronic kidney disease (CKD). Circular RNAs (circRNAs) are involved in certain renal diseases, but their role in RIF is largely unknown. The present study investigated the effects and potential mechanisms of circRNA_0017076 in RIF. CircRNA_0017076 expression was mark...
Introduction
Diabetic kidney disease (DKD) is one of the complications of diabetes; however, the pathogenesis is not yet clear. A recent study has shown that senescence is associated with the course of DKD. In the present study, we explored whether senescent renal tubular cells promote renal tubulointerstitial fibrosis by secreting Sonic hedgehog (...
![The design of novel Imidazo[1,2-a]pyridine derivatives based on PIK-75.](publication/367570564/figure/fig2/AS:11431281241797250@1715240461793/The-design-of-novel-Imidazo1-2-apyridine-derivatives-based-on-PIK-75_Q320.jpg)
Inhibition of PI3K pathway has become a desirable strategy for cancer treatment. In this work, a series of 2, 6, 8-substituted Imidazo[1,2-a]pyridine derivatives were designed and screened for their activities against PI3Kα and a panel of PI3Kα-addicted cancer cells. Among them, compound 35 was identified as a PI3Kα inhibitor with nanomolar potency...
A convenient method was developed for the preparation of thiolated compounds via a DBU-catalyzed aerobic cross-dehydrogenative coupling (CDC) reaction. The established protocol is environmentally friendly and operationally simple. Substrates like (hetero)aryl acetates, (hetero)aryl ketones, and indoles could be transformed into the corresponding th...
Previous studies have shown mitochondrial dysfunction in various acute kidney injuries and chronic kidney diseases. Lipoic acid exerts potent effects on oxidant stress and modulation of mitochondrial function in damaged organ. In this study we investigated whether alpha lipoamide (ALM), a derivative of lipoic acid, exerted a renal protective effect...
In order to find novel anti‐platelet drugs for the treatment of ischemic stroke, a series of 3‐n‐butylphthalide derivatives containing isopentenylphenol moiety were designed, synthesized and characterized with spectroscopic analyses. The in vitro antiplatelet activity results indicated that compound 3 better inhibited the arachidonic acid (AA) indu...
Peroxisome proliferator-activated receptor γ (PPAR γ) antagonists are a key instrument of insulin sensitizers since they have the ability to sensitize insulin and can avoid adverse reactions caused by receptor agonist. In this paper, two series of 28 novel Cajanonic acid A (CAA) derivatives were designed and synthesized. The biological activity sho...
The overuse of antibiotics will led to the increase of drug resistance. Especially, the multidrug-resistant A. baumannii became the leading cause of nosocomial infections with high rates of morbimortality. The drug resistance of A. baumannii is greatly attributed to its biofilm. To alleviate the burden of drug resistance, the anti-virulence signali...
The convenient and facile syntheses of amorfrutin A and amorfrutin B have been realized in five steps starting from commercially available 2,4‐dimethoxybenzoic acid with an overall yield of 32 % and 22 %, respectively. The key steps involved Ru(II)‐catalyzed olefination and straightforward C‐alkylation.
Aiming to search for novel potential antifungal agents, forty 2 H ‐chromene analogues were designed, synthesized and their antifungal activity against some typical plant pathogenic fungi were firstly evaluated. The in vitro antifungal bioassays showed that some of the target compounds exhibited comparable or better inhibition activities than the co...
Impaired protein N-glycosylation leads to endoplasmic reticulum (ER) stress, which triggers adaptive survival or maladaptive apoptosis in renal tubules in diabetic kidney disease (DKD). Therapeutic strategies targeting ER stress are promising for the treatment of DKD. Here, we report a previously unappreciated role played by ENTPD5 in alleviating r...
Background:
Renal fibrosis is a serious condition that results in the development of chronic kidney diseases. The MEN1 gene is an epigenetic regulator that encodes the menin protein and its role in kidney tissue remains unclear.
Methods:
Kidney histology was examined on paraffin sections stained with hematoxylin-eosin staining. Masson's trichrom...
An efficient radical annulation of N-arylacrylamides with disulfides is developed for the synthesis of sulfurated oxindoles. The reaction occurs in a facile manner using CoBr2 as both an initiator and a promoter for the first time and (NH4)2S2O8 as the oxidant. By controlling the CoBr2/(NH4)2S2O8 ratio, a wide range of sulfurated and brominated/sul...
Objective:
To investigate the effects of peroxisome proliferator-activated receptor (PPARγ) expression on renal podocyte in diabetic mice by conditionally knockout mouse PPARγ gene.
Methods:
Wild-type C57BL mice and PPARγ gene knockout mice were used as research objects to establish the diabetic mouse model, which was divided into normal control...
Diabetic kidney disease is one of the most serious microvascular complications of diabetes. It progresses irreversibly to end-stage renal disease if left untreated. Bone morphogenetic protein (BMP)-7 is a negative regulator of organ fibrosis and may also play an essential role in tubulointerstitial fibrosis. This study aimed to investigate the prec...
Diabetic kidney disease is a major cause of chronic kidney condition and the most common complication of diabetes. The cellular senescence participates in the process of diabetic kidney disease, but the specific mechanism is not yet clear. Cell cycle-related protein E2F transcription factor 1 (E2F1) is a member of the E2F transcription factor famil...
In order to find novel environment-friendly and effective antifungal agents, four series of 2,2-dimethyl-2H-chromene derivatives were designed, synthesized and characterized by spectroscopic analysis. The antifungal activities of all the target compounds against nine phytopathogenic fungi were evaluated in vitro. Preliminary results indicated that...
In order to discover novel antifungal agents, three series of simple 2-aminobenzoxazole derivatives were designed, synthesized and evaluated for their antifungal activities against eight phytopathogenic fungi. The in vitro antifungal results showed that most of the target compounds exhibited excellent and broad-spectrum antifungal activities to all...
Tubulointerstitial fibrosis (TIF) is involved in the development of diabetic kidney disease (DKD). Transforming growth factor β1 (TGF-β1) is involved in the extensive fibrosis of renal tissue by facilitating the partial epithelial-mesenchymal transition (EMT), increasing the synthesis of extracellular matrix (ECM), inhibiting degradation, inducing...
Atorvastatin is a classical lipid-lowering drug. It has been reported to have renoprotective effects, such as reducing urinary protein excretion and extracellular matrix aggregation. The present study aimed to investigate the specific mechanism of action of Atorvastatin in type 1 diabetic mice (T1DM) in inhibiting renal tubular epithelial cell inju...
Context
Ranunculus ternatus Thunb (Ranunculaceae), (RTT) is used clinically for the treatment of tuberculosis or as tumour adjuvant therapy, but its potential effect on diabetic nephropathy (DN) has not been studied.
Objective
To investigate the effect of RTT extract in renal fibrosis of DN.
Materials and methods
C57BL/6 mice were randomly divide...
Background
Non-alcoholic fatty liver disease (NAFLD) is characterized by ectopic accumulation of triglycerides in the liver. Emerging evidence has demonstrated that lipophagy regulates lipid mobilization and energy homeostasis in the liver. Sirtuin 3 (SIRT3), a mitochondrial NAD ⁺ -dependent deacetylase, modulates the activities of several substrat...
The balancing between tumor suppression and cell viability is the key to balance aging and tumorigenesis, and reach tumor-free longevity, or healthy aging. We speculate that the balance of tumor suppression signaling and the cell growth sustaining mechanisms in molecular genetics might reflect the balance between Yin and Yang in Chinese medicine. S...
Four series of cajanonic acid A (CAA) derivatives have been designed and synthesized. The newly prepared compounds have been screened for glucose consumption activity in HepG2 cell lines and PPARγ antagonistic activity in HEK293 cell lines. Compound 26g bearing a tetrahydroisoquinolinone scaffold showed the most potent PPARγ antagonistic and hypogl...
Ski-related novel protein N (SnoN) negatively regulates the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and is present at a low level during diabetic nephropathy (DN), but its underlying regulatory mechanism is currently unknown. The present study aimed to assess the effects of insulin-controlled blood glucose on renal SnoN expre...
Renal interstitial fibrosis (RIF) is the common irreversible pathway by which chronic kidney disease (CKD) progresses to the end stage. The transforming growth factor-β (TGF-β)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is a common factor leading to inflammation-mediated RIF, but its downstream regulatory mechanism...
Objective:
The goal of the present study was to determine the expression of yes-associated protein 1 (YAP1) in renal tissues of mice with lupus nephritis (LN) and elucidate its role in the progression of renal fibrosis.
Methods:
C57BL/6 mice and MRL/lpr mice were selected for experimental comparison. Mouse kidney tissues were removed and section...
Objective To observe the effects of DNA methyltransferase 3B (DNMT3B) on the expression of secreted frizzled-related protein 1 (SFRP1) and regulation of Wnt/β-catenin signaling pathway in renal tubular epithelial cells (RTECs) of mice under high glucose conditions. Methods in vitro cultured mouse RTECs were divided into normal glucose (NG) group an...
Two series of tetrahydrocarbazole derivatives have been designed and synthesized based on ZG02, a promising candidate developed in our previous studies. The newly prepared compounds were screened for glucose consumption activity in HepG2 cell lines. Aza-tetrahydrocarbazole compound 12b showed the most potent hypoglycemic activity with a 45% increas...
Chronic kidney disease is a global health problem and eventually develops into an end‐stage renal disease (ESRD). It is now widely believed that renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of ESRD. Renal tubular epithelial‐mesenchymal transition (EMT) is an important cause of TIF. Studies have shown that FGF2...
A mild and green methodology for the regiodivergent functionalization of isoquinoline‐1,3(2 H ,4 H )‐diones under aerobic condition was developed. Under catalytic amount of base, heteroatom nucleophiles went through imide opening/ring contraction sequence to give thermodynamic controlled product; while carbon based nucleophiles led to kinetic contr...
Renal tubules are vulnerable targets of various factors causing kidney injury in diabetic kidney disease (DKD), and the degree of tubular lesions is closely related to renal function. Abnormal renal tubular epithelial cells (RTECs) differentiation and depletion of cell junction proteins are important in DKD pathogenesis. Caudal-type homeobox transc...
Acinetobacter baumannii (A. baumannii), one of the major pathogens that causes severe nosocomial infections, is characterised by a high prevalence of drug resistance. It has been reported that A. baumannii triggers the NOD-like receptor 3 (NLRP3) inflammasome, but the role of its virulence-related outer membrane protein A (ompA) remains unclear. Th...
Etoposide‐induced 2.4 (EI24) exerts tumor suppressor activity through participating in cell apoptosis, autophagy, and inflammation. However, its role in renal diseases has not been elucidated. This study showed that the EI24 level decreased gradually in the kidneys of mice with unilateral ureteral obstruction (UUO) and in another fibrosis model ind...
Objective:
To investigate the expression of Stim1 in the kidneys of mice with lupus, and the effect of Stim1 on the progression of renal interstitial fibrosis.
Methods:
Mice (MRL/lpr) with spontaneous lupus nephritis (LN) and normal control mice (C57/BL) were selected. Immunohistochemistry and Masson staining were used to determine the degree of...
Etoposide-induced protein 2.4 (EI24) is an autophagy-associated protein and acts as a tumor suppressor. However, its role in tissue fibrosis remains unknown. Herein, a downregulation of EI24 levels in the lungs from mouse pulmonary fibrosis (PF) model and lung epithelial cells was observed in response to bleomycin (BLM) or transforming growth facto...
The aim of this paper was to observe the effect of salvianolic acid B(Sal B) on high-glucose induced renal tubular epithelial-mesenchymal transition(EMT) in rats, and to explore its possible mechanisms of prevention and treatment of diabetic nephropathy. The rat renal tubular epithelial NRK-52 E cells were cultured in vitro. The cells were divided...
The final pathway for the development of diabetic nephropathy (DN) into chronic renal failure in DN is glomerulosclerosis and tubulointerstitial fibrosis. Renal tubular lesions can occur in the early stage of DN renal injury. Cumulative evidence shows that oxymatrine (OMT) has a variety of biological and pharmacological properties. In recent years,...
Diabetic nephropathy (DN) commonly causes end-stage renal disease (ESRD). Increasing evidence indicates that abnormal miRNA expression is tightly associated with chronic kidney disease (CKD). This work aimed to investigate whether miR-27a can promote the occurrence of renal fibrosis in DN by suppressing the expression of secreted frizzled-related p...
Objective To investigate the effect of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) on the development of renal tubular epithelial-mesenchymal transformation (EMT) and diabetic nephropathy (DN). Methods Mouse model of type 1 diabetic nephropathy (T1DN) was established by intraperitoneal injection of streptozotocin (STZ) (55 mg/k...
Objective To explore the expression of renal cortex bone morphogenetic protein and activating protein membrane binding inhibitor (BAMBI), NLR family pyrin domain containing 3 (NLRP3), apoptosis-associated speck like protein containing a CARD-2 (ASC-2), caspase-1, inflammatory mediators and related fibrosis markers in renal cortex of diabetic mellit...
The biological function of long non‑coding RNA00261 (Linc00261) has been widely investigated in various types of cancer. The aim of the present study was to explore the role of Linc00261 in pancreatic cancer (PC). The expression of Linc00261 in patients with PC and PC cell lines was assessed using reverse transcription‑quantitative PCR and the asso...
It is widely known that abnormal regulation of microRNAs (miRNAs/miRs) may contribute to the occurrence or development of tumors. The objective of the present study was to elucidate the function and underlying mechanism of miR‑137 in the progression of cholangiocarcinoma (CCA). The expression levels of miR‑137 in CCA tissues and cell lines were mea...
Diabetic nephropathy (DN) is a serious microvascular complication of diabetes mellitus.The main pathological features of DN include glomerular sclerosis and renal tubular interstitial fibrosis, which results in epithelial mesenchymal transition (EMT) and excessive extracellular matrix (ECM) deposition.Transforming growth factor-β1(TGF-β1) is a crit...
Epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) deposition in renal tubular epithelial cells are critical to diabetic nephropathy (DN) pathogenesis, but the underlying mechanisms remain undefined. Bone morphogenetic protein 7 (BMP-7) inhibits EMT and ECM accumulation in renal tubular epithelial cells cultured in presence of h...
Renal tubular epithelial–mesenchymal transition (EMT) is the main pathological change in diabetic renal tubulointerstitial fibrosis. Mounting evidence indicates that the inhibitor of differentiation 2 (Id2) protein acts as a negative regulatory factor in organ fibrosis and can inhibit or reverse the process of fibrosis. However, its specific regula...
Objective To analyze the changes and correlation between inflammation and Klotho expression in kidney tissue of mice with acute kidney injury (AKI) induced by cisplatin, and to explore the role and possible mechanism of Klotho in AKI induced by cisplatin. Methods Eighteen male C57BL/6 mice were randomly divided into 0-day group, 1-day group and 3-d...
Aims
This study aimed to investigate the role of transforming growth factor-β-activated protein kinase 1(TAK1) in the development of diabetic nephropathy (DN) by regulating the protein stability of Ski-related novel protein N(SnoN).
Main methods
A combination of in vivo and in vitro model systems was used to investigate how TAK1 regulated the expr...
Unveiling the mechanisms that drive the pathological phenotypes of diabetic nephropathy (DN) could help develop new effective therapeutics for this ailment. Transforming growth factor‐β1 (TGF‐β1)/Smad3 signaling is aberrantly induced in DN, leading to elevated microRNA‐21 (miR‐21) expression and tissue fibrosis. Ski‐related novel protein (SnoN) neg...
Renal tubular epithelial‐to‐mesenchymal transition (EMT) and tubulointerstitial fibrosis (TIF) are important pathological features of diabetic nephropathy (DN). However, the regulatory mechanism underlying EMT and TIF are still unclear. Previous studies showed that the decrease in the expression of phosphatase and tensin homolog deleted on chromoso...
Background
Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of the lungs. Collagen is the primary protein component of the ECM. However, the exact mechanisms underlying the formation and deposition of collagen in the ECM under normal and pathological conditions remain uncl...
Figure 1: NRK-52E cells were treated with normal glucose, high glucose, or mannitol for 48 h; the protein levels of LC3-I, LC3-II, p62, and Col IV were detected by Western blot. ImageJ densitometric analysis of the protein levels; data represent mean ± SEM, n = 3, ∗
P < 0.05, ∗∗
P < 0.01, ns: not significant.
Citations
... Besides, an increasing number of studies indicate that M1 macrophages may influence the tissue microenvironment through the secretion of exosomes, which function to transport molecules containing biological information (Momen-Heravi et al., 2014). Lou et al. (2023) discovered that miRNA-155-5p, which is highly expressed in exosomes derived from M1-polarized macrophages, exerts antiangiogenic effects by targeting the GDF6-Akt axis, ultimately impacting the healing process in diabetic conditions. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/988912935763973-1612786625860_Q64/Zhang-Tian-13.jpg)
... For example, harpertrioate A reduced Aβ42 and Aβ40 production and shifted APP processing toward a nonamyloidogenic pathway, while perforalactones D and E significantly induced lysosomal biogenesis through transcriptional activation of lysosomal genes [6,22]. As part of our ongoing work to discover [23] bioactive molecules from plant [14,20,21,[24][25][26][27], we isolated seven undescribed quassinoids (1)(2)(3)(4)(5)(6)(7), including six C-20 and one C-19 quassinoids from the twigs of this plant. We also verified the oxidative degradation of C-25 quassinoid, perforalactone B (Figure 1), to the C-20 quassinoid, perforaquassin A, through chemical transformation, and then the crucial "link" between C-25 type and C-20 type quassinoids was proposed. ...
... The upregulated Wnt signaling pathway could facilitate the proliferation of vascular endothelial cells and promote angiogenesis [43]. The promotion of accelerated angiogenesis plays a critical role in the process of healing diabetic wounds, as it facilitates the delivery of oxygen and nutrients to the compromised tissue, thereby mitigating extensive inflammation and combating bacterial infection [44]. Nevertheless, the presence of an extensive local inflammatory reaction hinders the progression of angiogenesis in diabetic wounds, including bacterial infection, excessive oxidative stress, and uncontrolled infiltration of inflammatory cells. ...
... CEBPB mRNA expression was significantly elevated in PBMCs from a cohort of 20 SLE patients compared to 20 gender/age-matched healthy controls [38]. Further studies demonstrated that CEBPB expression was also significantly elevated in LN patients and possibly positively associated with disease progression [39,40]. Interestingly, higher-CEBPB SLE patients tend to have a high titer of certain autoAbs (anti-Sm, anti-SNP, or ANA). ...
... These characteristics pose challenges in their development and use as therapeutic agents and have been terminated in clinical evaluation due to poor tolerance and drug resistance. This suggests that further safety and efficacy improvements are needed (Zhang et al., 2023). Someone discusses the use of virtual screening methods to discover potential inhibitors of ubiquitination regulators for cancer treatment. ...
... As splicing factors act to prevent R-loop formation during RNA transcription, and unscheduled R-loops lead to DNA damage and genomic instability after splicing factor depletion (Goulielmaki et al., 2021;Jimenez et al., 2019;Jin et al., 2023;Li et al., 2005), we speculated that LUC7L3 depletion may lead to aberrant R-loop formation. To investigate whether LUC7L3 depletion leads to aberrant R-loop formation, we monitored R-loops using the S9.6 antibody, which specifically detects DNA-RNA hybrids (Boguslawski et al., 1986;Bou-Nader et al., 2022). ...
... Some studies have reported that renal tubular change has been an essential predictor of kidney impairment in late-stage diabetic kidney disease, including the degree of interstitial fibrosis and renal tubular atrophy (IFTA) score. 4 Several molecular pathways are associated with the pathogenesis of renal fibrosis, 5 including inflammation, 6 endoplasmic reticulum stress, 7 oxidative stress, 8 and autophagy. 9 Autophagy is an evolutionarily conserved homologous cellular process that plays a vital role in the degradation of damaged organelles and abnormal proteins to maintain cellular metabolism. ...
... For example, Niu et al. demonstrated that Circ_0008529 contributes to renal tubular cell dysfunction under high glucose stress through the miR-185-5p/SMAD2 pathway in diabetic nephropathy [24]. Furthermore, circRNA_0017076 modulates epithelial-to-mesenchy -mal transition during renal interstitial brosis by acting as a sponge for miR-185-5p [25]. These discoveries underscore the crucial role of circRNAs in kidney diseases. ...
... This effect mirrors the beneficial impact of exercise on fetal BAT generation and offspring metabolism, achieved through the heightened expression of PRDM16, a key transcription factor in brown adipogenesis [101,120]. Exercise-induced Metrnl is linked to increased fat oxidation and insulin sensitivity, reduced inflammation, modulation of mitochondrial homeostasis, and physiological effects associated with the browning of WAT [121,122]. BAIBA, a small-molecule myokine released from PGC-1α-expressing myocytes, promotes thermogenesis and induces WAT browning by increasing β-oxidation in hepatocytes by a PPARα-mediated mechanism in response to 8 weeks of treadmill exercise (50-60% maximal intensity). Additionally, BAIBA mitigates mitochondrial dysfunction and decreases cardiometabolic risk in individuals with obesity [107,123]. ...
... 15 Under conditions of high glucose and high lipid, downregulation of miR-124-3p can induce FOXQ1 in renal tubular epithelial cells, thereby inhibiting SIRT4, leading to mitochondrial dysfunction, and promoting the occurrence of diabetic nephropathy. 33 In our experiments, we found that KLF6 silence could mitigate mitochondrial dysfunction in CSE-induced BEAS-2B cells through SIRT4 upregulation. ...
