Angela Iervolino's research while affiliated with Istituto Regina Elena - Istituti Fisioterapici Ospitalieri and other places
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Publications (4)
We have previously demonstrated that bcl-2 overexpression in tumor cells exposed to hypoxia increases the expression of vascular endothelial growth factor (VEGF) gene through the hypoxia-inducible factor-1 (HIF-1). In this article, we demonstrate that exposure of bcl-2 overexpressing melanoma cells to hypoxia induced phosphorylation of AKT and extr...
The aim of this study was to assess whether lonidamine (LND) interferes with some steps in angiogenesis progression. We report here, for the first time, that LND inhibited angiogenic-related endothelial cell functions in a dose-dependent manner (1-50 microg/ml). In particular, LND decreased proliferation, migration, invasion, and morphogenesis on m...
We have previously demonstrated that Bcl-2 overexpression in human breast carcinoma and melanoma cells synergizes with hypoxia to increase angiogenesis through up-regulation of vascular endothelial growth factor. In this work we demonstrated, for the first time, that Bcl-2 overexpression in cancer cells exposed to hypoxia modulates urokinase plasmi...
The aim of this paper was to study the molecular mechanisms by which bcl-2 increases hypoxia-induced vascular endothelial growth factor (VEGF) expression. We demonstrated that bcl-2 overexpression in M14 human melanoma cell line enhances hypoxia-induced VEGF mRNA stability and promoter activation. In particular, the half-life of the message was lon...
Citations
... Disarib is derived from Z24 compounds that possess anti-angiogenic properties [25,64]. Bcl2 is involved in crosstalk with VEGF-mediated signalling, and overexpression of Bcl2 leads to increased angiogenesis [17,18,22,65]. TW37, a Bcl2 inhibitor, has shown anti-angiogenic properties [24]. ...
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... The integrity of the actin cytoskeleton is critically important to the ability of cells to migrate. It is known that LND significantly inhibits endothelial cell migration and invasiveness (115). LND treatment caused the disappearance of actin stress fibers and rearrangement of intermediate filaments and microtubules (116). ...
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... The latter are inactive in trap-spaces 2, 3, 4, and 6. It reflects the regulation of BCL2 through the MAPKs pathway [72]. ...
... It was reported that hypoxia promotes spontaneous lymph node metastasis in human melanoma xenografts by up-regulating uPAR [84]. Both increased uPAR mRNA stability and expression, due to the presence of HRE at the uPAR promoter, have been reported under hypoxia in different tumor histotypes, including CM [85][86][87]. We previously reported that overexpression of Bcl-2 in CM cells exposed to hypoxia was able to modulate uPAR expression through Sp1 transcription factor [87]. ...
