Alejandro Comellas's research while affiliated with University of Iowa Children's Hospital and other places
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Publications (4)
Introduction
Chronic bronchitis (CB), a phenotype of chronic obstructive pulmonary disease (COPD) characterised by persistent cough and mucus hypersecretion, is associated with poor outcomes despite guideline-based treatment. Bronchial rheoplasty (BR) with the RheOx system delivers non-thermal pulsed electric fields to the lower airway epithelium a...
Rationale:
The SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS) is a prospective cohort study that enrolled 2981 participants with the goal of identifying new chronic obstructive pulmonary disease (COPD) subgroups and intermediate markers of disease progression. Individuals with COPD and obstructive sleep apnea (OSA) expe...
Introduction:
Recent evidence suggests a high prevalence of undiagnosed chronic obstructive pulmonary disease (COPD). These individuals are at risk of exacerbations and delayed treatment. We analyzed an at-risk population for the prevalence of abnormal spirometry to provide clarity into who should undergo early spirometry.
Methods:
We analyzed d...
Background
Current treatment strategies to stratify exacerbation risk rely on history of ≥2 events in the previous year. To understand year-to-year variability and factors associated with consistent exacerbations over time, we present a prospective analysis of the SPIROMICS cohort.
Methods
We analyzed SPIROMICS participants with COPD and three yea...
Citations
... In a study of individuals with a smoking history and no known obstructive lung disease, 21% had undiagnosed airflow obstruction; moreover, within a 5-year follow-up period, Modified Medical Research Council score ≥2, chronic productive cough, worsening respiratory symptoms during the follow-up period, and abnormal spirometry were found to be risk factors for subsequent COPD development. 14 We could not conduct a detailed survey in an undiagnosed population; moreover, the available data were limited by the use of a database derived from the health insurance association. Although it is difficult to compared the previous findings with the present findings, we believe that identifying individuals at risk as indicated in previous studies may facilitate prompt COPD diagnosis. ...
... Patients with SAD were more likely to report respiratory symptoms such as dyspnea, cough, and chronic phlegm, even if they had never smoked [21,29]. Additionally, SAD in patients with COPD or asthma was found to be associated with more exacerbations, poorer disease control, and increased dyspnea [23,30,31]. Some patients recovered from lung hyperinflation between two and eight months after COVID-19 infection, whereas a small proportion of those without SLH developed lung hyperinflation. ...
