Charles A. Waldron's research while affiliated with Emory University and other places
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Publications (17)
The distinguishing histopathologic features of focal cemento-osseous dysplasia (FCOD) (including lesions occurring in both anterior and posterior jaws) and cemento-ossifying fibroma (COF) (ossifying fibroma and cementifying fibroma) were demonstrated in our earlier work. The aim of the current study was to further refine their clinical and radiogra...
Focally expressed cemento-osseous dysplasia (periapical cemento-osseous dysplasia and focal cemento-osseous dysplasia) and cemento-ossifying fibroma (ossifying fibroma and cementifying fibroma) are two clinically recognized entities that are not easily differentiated histopathologically because of the lack of recognition of specific microscopic fea...
Cemento-osseous dysplasia (COD) (periapical cemento-osseous dysplasia and focal memento-osseous dysplasia) and cemento-ossifying fibroma (COF) (ossifying fibroma and cementifying fibroma) are two clinically recognized entities that are not easily differentiated histopathologically because of the lack of recognition of specific microscopic features....
Giant cell lesions of the maxilla and paranasal sinuses represent a rare, locally aggressive disorder which present as a soft tissue mass with distinct histologic and clinical features. There is considerable controversy on the therapeutic modalities, the prediction of clinical behavior based on histologic features, and whether these growths are rea...
To examine whether giant cell lesions of the jaws (GCL) of varying behavior could be separated histologically, a number of GCL were studied using the AgNOR staining technique for nucleolar organizer regions. The mean AgNOR count of mononuclear cells from recurrent lesions (1.73 +/- 0.15) was slightly higher than that of the aggressive lesions (1.54...
In the first volume of the Journal of Oral Surgery, Dr G. Victor Boyko presented a case of osteofibroma of the mandible associated with leontiasis ossea of the skull (Boyko GV: J Oral Surg 1:100, 1943). The patient was a 32-year-old white woman who had complaints of right mandibular enlargement and a prominence of the right frontal and temporal are...
The histology, radiographs, and follow-up information for 142 cases of central giant cell lesions of the jaws were reviewed in an effort to determine which, if any, microscopic features could be correlated with clinical behavior. The majority of these lesions were asymptomatic and relatively innocuous. However, some displayed a more aggressive clin...
Whether the peripheral ameloblastoma (PA) and intraoral basal cell carcinoma (BCC) are two different clinical entities or essentially the same lesion still remains unresolved. The immunophenotypes of neoplastic cells of peripheral and intraosseous ameloblastomas, ameloblastic carcinomas, and BCCs were studied using a panel of monoclonal/polyclonal...
Infantile myofibromatosis (IMF) is a benign localized (solitary) or generalized (multicentric) proliferation of fibroblastic tissue occurring exclusively in infants and children. Three cases of solitary IMF involving the posterior region of the mandible of young children are reported. These lesions manifested clinically as asymptomatic bony expansi...
Two cases of primary intraosseous squamous carcinoma (PIOSC) are reported. One PIOSC is in the mandible of a 24-year-old man and appears to be a keratinizing PIOSC arising de novo. The other PIOSC presented in the edentulous maxilla of a 56-year-old man and was diagnosed as a PIOSC arising from an odontogenic cyst. The 2nd tumor subsequently metast...
Primary intraosseous carcinoma of the jaws (PIOC) is an uncommon lesion, but may not be as rare as commonly believed. Since the putative source of the epithelium giving rise to an intraosseous carcinoma is the epithelium involved in odontogenesis, these lesions are often designated as odontogenic carcinomas. These tumors may theoretically arise (1)...
Osteoblastoma is an uncommon bone tumor comprising only about 1% of all skeletal neoplasms. The tumor is most commonly found in the vertebral column and long bones.1 The frequency of jaw involvement is uncertain, but is probably more common than the literature would indicate. A recent review by Weinberg and associates2 noted 30 previously reported...
In a demographic and histologic study of 426 oral minor salivary gland tumors, 57.5% were classified as benign and 42.5% were classified as malignant or potentially malignant. There was an overall female preponderance (1.59/1). The mean age for females was 53.1 years and for males was 50.6 years. The mean age for patients with malignant tumors was...
The histopathologic features of 116 ameloblastomas were reviewed with special reference to the incidence of the recently described desmoplastic variant. The series included 110 intraosseous lesions and 6 extraosseous ameloblastomas. Ninety-six (88%) of the intraosseous tumors were found in the mandible, and 61% involved the molar-ascending ramus ar...
Two cases of aggressive intraosseous epithelial tumor of the jaws are presented. Both tumors demonstrated an unusual biphasic pattern with areas of acceptable follicular ameloblastoma together with a conspicuous clear-cell component. The clinical course indicates these lesions should be considered as low grade odontogenic carcinomas. Further subcla...
Citations
... Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor first reported in the 1980s. It was initially referred as a clear cell ameloblastoma by Waldron et al. (1985) and as a clear cell odontogenic tumor by Hansen et al. (1985) [1,2]. The World Health Organization (WHO) classified it, in 1992, as a locally invasive benign tumor. ...
... The bone deposit may have two distinct patterns (commonly with a mix of the two patterns). One pattern consists of mineralized psammomatoid globules, resembling the normal cementicles seen in the periodontal ligament (the Bcementifying fibromas^ described in previous publications) [55, 56] . This morphological aspect may be indistinguishable from the cementifying type of fibrous dysplasia . ...
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... After the first description by Stout in 1954 (3), who gave the name of congenital generalized fibromatosis, 3 types of IM have been categorized: solitary, multicenter without visceral involvement, multicenter with visceral involvement (4). The solitary form represents 60% of the IM and only 5% are localized in bone affecting in most of these cases the craniofacial bones (2,5,6). Solitary lesion generally has a favorable prognosis if totally removed with a 10% recurrence rate (2,7). ...
Reference: Infantile myofibromatosis of the iliac bone
... Clinical features of PIOSCC are really non-specific. Patients most commonly present with jaw swelling and pain, and paraesthesia or numbness of the mandibular nerve are frequent as well [1,2,24,28]. It should be noted that early-stage PIOSCC might frequently be asymptomatic or might cause mild dental disorders, then leading to diagnostic delay [1]. ...
... Central MEC is one of the main differential diagnoses of GOC and some authors including Magnusson et al., have considered GOC as the benign variant of central MEC and that GOC has a very high potential to turn into a low grade mucoepidermoid carcinoma. 13,14 However, absence of epidermoid and intermediate cells in the GOC lining helps in differentiating between the two lesions. Cytokeratin 7, 14, and 19 positivity in GOC has proved its odontogenic origin along with a negative reaction for epithelial membrane antigen (EMA) marker which shows positivity in MEC and other salivary gland lesions. ...
... Intraosseous mucoepidermoid carcinoma of the mandible Although rare, intraosseous carcinoma appearing in the bones of the jaw, which was first described by Loos in 1913 as a central epidermoid carcinoma, is a recognized clinical entity (12). Later, Waldron and Mustoe (13) suggested that intraosseous MEC is included in the classification of "primary intraosseous carcinoma" (PIOC) as type 4 ( Table 2). This is based on the fact that the MEC of the jaw arises from the epithelial remnants of an odontogenic cyst and is histologically similar to salivary MEC. ...
... Pleomorphic adenoma, or benign mixed tumor, is the most common tumor of salivary gland origin, with ordinary sites being the palate, lip, buccal mucosa, floor of the mouth, and tongue. [1][2][3] These firm, mobile lesions comprise a majority of parotid and submandibular tumors, as well as some minor salivary gland tumors, with the posterior lateral hard and soft palate being typical locations for minor salivary gland neoplasms, followed by the upper lip and buccal mucosa. 4 These nodular masses have a female predilection between the ages of 30-50 and are hardly associated with pain. ...
... On very rare occasions, however, these tumours may demonstrate progressive growth, local recurrence and, less frequently, malignant transformation. [1][2][3][4][5][6] Although the first case of benign osteobalstoma of the maxilla was reported back in 1967, 7 unfortunately most of the reported cases lacked a comprehensive description of the imaging findings. Previous studies reported 3,4,7-15 that generally the lesion had well-defined borders and might have a completely radiolucent appearance, or it might show radiolucencies and radio-opacities. ...
Reference: Recurrent osteoblastoma of the maxilla
... Misdiagnosis risks erroneous prognostication and inappropriate or delayed treatment for canine patients. In humans, DA is reported most often in the anterior and premolar regions in middle aged adults (10)(11)(12). Radiographically, DA appears as a mixed radiolucent and radiopaque swelling, often resembling a benign fibro-osseous lesion ...
... The use of tumour markers can aid in diagnosis when tissue samples are of poor quality, and immunohistochemical evaluation has been used in human medicine. The expression of CK 5 and CK 14, which are markers of ameloblastoma in human medicine (Vigneswaran et al. 1993), has been used to identify this tumour in horses (De Cock et al. 2003). ...
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