Supplementary file 2.

Abstract

GDC-0810 and fulvestrant mouse pharmacokinetic data.
(A) GDC-0810 mouse pharmacokinetics (B) Fulvestrant plasma concentrations.
DOI:
http://dx.doi.org/10.7554/eLife.15828.021

Full text

Supplementary File 2A: GDC-0810 Mouse Pharmacokinetics
Compound Dose
(mg/kg/day) Clast (µg/mL) T1/2 (hr) AUC0-t
(µg·hr/mL)
Cmax
(µg/mL)
Tmax
(hr)
GDC-0810
10 0.007 8.0 5.5 1.637 1.0
30 0.013 4.0 21.5 5.333 1.0
100 0.216 3.0 94.1 9.313 8.0
Compound
CL
(mL/min/kg)
Vss
(L/kg)
t1/2
(hr)
Cmax (Oral)
(µg/mL)
AUC0-inf (Oral)
(µg·hr/mL)
Oral
%F
GDC-0810 11 1.2 2.6 4.4 8.8 61
Supplementary File 2B: Fulvestrant Plasma Concentrations
Compound
Regimen Day Time (hr)
Plasma Conc (µg/mL)
Frequency Dose
(mg/kg) Mean SD
Fulvestrant 3x/wk 200 57 0 0.665 0.236
Fulvestrant 3x/wk 200 28 0 0.731 0.7128
Fulvestrant Days 1, 3 & 8
Days 15 & 22
50
25 21 0 0.015 0.009