... Mitochondrial DNA is double stranded like the nuclear DNA, but circular instead of linear. The mitochondrial genome encodes exclusively for two ribosomal RNAs (rRNAs), 22 transfer RNAs (tRNAs), and the messenger RNA (mRNA) of 13 protein subunits that are assembled with nuclear-encoded proteins to form the four enzymatic complexes constituting the mitochondrial (Teuber and Bader, 1976;Suzuki et al., 2013;Deris et al., 2014;Lu et al., 2016;Visentin et al., 2017) Doxycycline OATs Mitochondrial ribosome (Clark-Walker and Linnane, 1966;Babu et al., 2002;Houtkooper et al. 2013;Moullan et al., 2015) Gentamicin Megalin and OCT2 Mitochondrial ribosome Complex II (Prezant et al., 1993;Moestrup et al., 1995;Qian and Guan, 2009;Gai et al., 2016;O'reilly et al., 2019) Vancomycin OCTs Complex I (Sokol, 1991;Arimura et al., 2012;Fujiwara et al., 2012;Sakamoto et al., 2017) Anticancer Cisplatin OCTs Mitochondrial DNA VDAC (Yang et al., 2006;Garrido et al., 2008;Filipski et al., 2009;Ciarimboli et al., 2010) Gemcitabine CNTs and ENTs DNA polimerase γ (Mackey et al., 1998;Fowler et al., 2008) Ifosfamide OCT2 Complex I (Nissim et al., 2006;Knouzy et al., 2010;Ciarimboli et al., 2011) Methotrexate FRα, RFC, PCFT, OATs, and OATPs Mitochondrial TS (Hoar and Dimnik, 1985;Badagnani et al., 2006;Zhao et al., 2011;Visentin et al., 2012) Nitrosourea derivatives OCTs Mitochondrial DNA (Wunderlich et al., 1970;Pettepher et al., 1991;Chen et al., 2001 Frontiers in Physiology | www.frontiersin.org electron transport chain. ...