Nora Martel

Hepatitis delta virus (HDV) increases morbidity in Hepatitis B virus (HBV)-infected patients. In the mid-eighties, an outbreak of HDV fulminant hepatitis (FH) in the Central African Republic (CAR) killed 88% of patients hospitalized in Bangui. We evaluated infections with HBV and HDV among students and pregnant women, 25 years after the fulminant h...

Occupation of subjects from the 2 cohorts (student and pregnant women) in function of HBV and HDV status. (DOC)

Comparison of age, marital status, and blood borne and sexual risk factors in students infected or non-infected by HBV (HBV positive versus negative) in CAR in year 2010. (DOCX)

A: Consensus tree obtained from PreS1 region analysis of the HBV genome (nt 2817–nt81) of reference sequence from Galibert et al. (Nature. 1979) obtained from 49 isolates from asymptomatic HBV-infected students sampled in Bangui in 2010. PreS1 sequences were obtained by hemi-nested PCR as previously described [20]. Bayesian analyses were conducted...

Students repartition among high schools and University departments. This list corresponds to almost all different high educational entities in Bangui, Central African Republic. (DOC)

Comparison of age, marital status, and blood borne and sexual risk factors in pregnant women infected or non-infected by HBV (HBV positive versus negative) in CAR in year 2010. (DOCX)

Age, marital status, district address in Bangui, and blood borne and sexual risk factors in students and pregnant women in Central Africa Republic (CAR) in year 2010. (DOC)

Comparison of age, marital status, and blood borne and sexual risk factors in students infected or non-infected by HDV (HDAg ± anti-HD Abs positive versus negative) in CAR in year 2010. (DOCX)

HDV sequences from this study Accession Summary ----------------- Type Accession Unique Name Study PRJEB24597 ena-STUDY-Research Cancer Center of Lyon-24-01-2018-10:05:53:847–48 European Nucleotide Archive (ENA). (DOC)

A: Consensus tree obtained from the PreC-C region of the HBV genome (nt1814–nt2495) of reference sequence from Galibert et al. (Nature. 1979). HBV DNA was amplified from DNA extracted from the 40 initial ancestral samples with Macherey Nagel extraction procedures. Amplification yielded positive results in 8 samples, and DNA was directly sequenced f...

French to English translated questionnaire. (DOCX)

Place of living of the studied cohort in the different districts (1–8) of Bangui capital and Bimbo suburbs district in function of HBV and HDV status. The gray scale indicates the economical status of the district. (DOC)

Comparison of age, marital status, and blood borne and sexual risk factors in pregnant women infected or non-infected by HDV (HDAg ± anti-HD Abs positive versus negative) in CAR in year 2010. (DOCX)

Hepatitis B virus (HBV) infection remains a major public health concern worldwide with 240 million individuals chronically infected and at risk of developing cirrhosis and hepatocellular carcinoma. Current treatments rarely cure chronic hepatitis B infection, highlighting the need for new anti-HBV drugs. Nucleic acid polymers (NAPs) are phosphoroth...

For functional analysis of HBV isolates, epidemiological studies and correct identification of recombinant genomes, the amplification of complete genomes is necessary. A method for completely in vitro amplification of full-length HBV genomes starting from serum RC-DNA is described. This uses in vitro completion/ligation of plus-strand HBV RC-DNA an...

A number of risk factors appear to play a role in hepatocellular carcinoma (HCC), hepatitis B infection being one of the most important. Hepatitis B surface antigen (HBsAg) is the hallmark of hepatitis B virus (HBV) since it is the best and most reliable diagnostic marker. However, since most studies do not rely on longitudinal observations but mos...

We describe a patient infected with human immunodeficiency virus who possessed a serological profile suggesting a previous cleared acute hepatitis B virus (HBV) infection, including high levels of antibodies against HBV surface antigen (anti-HBs). Following the administration of inhaled glucocorticosteroids combined with protease inhibitor–based an...

L'infection chronique ou occulte par le virus de l'hépatite B (HBV) est l'un des facteurs de risque les plusimportants pour le développement de carcinome hépatocellulaire viro-induit. Malgré la petite taille dugénome et les contraintes imposées par l'organisation de ce génome, le HBV présente une grandevariabilité génétique qui est le résultat des...

Small hepatitis B virus surface protein (S-HBsAg) variant Y100C has been associated with HBsAg-negative phenotype. To determine whether Y100C substitution yields impaired HBsAg or small amounts of HBsAg that may reduce HBsAg detection by commercial anti-HBsAg antibodies, two eukaryotic expression plasmids, one containing a wild-type S and the other...