Mohamad E Helal

Mansoura University · Deprtment of Oral Biology

Objective This study was carried out in submandibular salivary glands of rats to demonstrate the changes induced by cadmium intoxication and the possible prophylactic and therapeutic effects of bone marrow mesenchymal stem cells (BMSCs). Design Sixty-five rats were divided into five groups. Rats in Group I were controls while those of Group II rec...

Background and Objective: Cadmium chloride (Cd cl 2) is a highly toxic heavy metal that causes severe degenerative effects to different body organs. Bone marrow mesenchymal stem cells (BMMSCs) may have a protective effect upon CdCl 2 induced structural and functional changes in the rat's organs. This systematic review aimed to test the regenerative...

Objectives: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) after regenerative surgeries may affect the behavior of stem cells used during the treatment. This study investigates the possible effect of NSAIDs on the proliferation and the osteo-differentiation of dental pulp stem cells (DPSCs) in vitro. Methods : DPSCs were isolated, culture...

Background and Objective: Cadmium chloride (Cd cl2) is a highly toxic heavy metal that causes severe degenerative effects to different body organs. Bone marrow mesenchymal stem cells (BMMSCs) may have a protective effect upon CdCl2 induced structural and functional changes in the rat’s organs. This systematic review aimed to test the regenerative e...

BACKGROUND Critically sized bone defects represent a significant challenge to orthopaedic surgeons worldwide. These defects generally result from severe trauma or resection of a whole large tumour. Autologous bone grafts are the current gold standard for the reconstruction of such defects. However, due to increased patient morbidity and the need fo...

Introduction: Partial pulpotomy is a vital treatment for carious and traumatic exposure, especially in young permanent teeth. Cell-based therapy for partially pulpotomized teeth can be considered a promising approach for dentin-pulp complex regeneration. This study evaluated the healing capacity of autologous bone marrow-derived stem cells (BMSCs)...

This study evaluated the effect of Gelfoam sponge with and without autologous bone marrow-derived stem cells (BMSCs) on bone regeneration in critical-size mandibular defects. The study involved 56 New Zealand rabbits assigned to four groups (14 in each). The osseous defects in group I were irrigated with normal saline, those in group II were grafte...

This study aimed to investigate the effects of aqueous cinnamon extract (ACE) on 7, 12-Dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch (HCP) mucosa. Sixty male Syrian hamsters were randomly divided into six equal groups. The hamsters of groups I, II and III received no treatment, DMBA and ACE respectively, for 16...

Objective To evaluate the possible regenerative effect of allogenic gingival margin-derived stem cells (GMSCs) with or without autologous fibrin glue on partially dissected submandibular salivary glands of albino rats. Methods Forty rats were randomly divided into four equal groups. Group I, where no operation was performed, was considered the neg...

Background and Objectives: The imperative role of dental pulp stem cells (DPSCs) in regenerative therapy demands an in-vitro expansion which must deal with the safety and ethical problems associated with fetal bovine serum (FBS). The primary aim of this study was to compare the effects of human platelet rich fibrin (hPRF) exudate Vs FBS on prolifer...

Purpose This study evaluated the effect of bone marrow-derived stem cells (BMSCs) on degenerative changes of TMJ associated with bovine collagen type II (BCII) induced-arthritis. Materials and Methods Fifty rabbits were divided into three groups as follows: group I (n=10); received no treatment. Group II (n=20); assigned into two subgroups accordi...

Objective: To evaluate the possible regenerative effect of allogenic gingival margin-derived stem cells (GMSCs) with or without autologous fibrin glue on partially dissected submandibular salivary glands of albino rats. Methods: Forty rats were randomly divided into four equal groups. Group I, where no operation was performed, was considered the ne...

Background and objectives: The imperative role of dental pulp stem cells (DPSCs) in regenerative therapy demands an in-vitro expansion which must deal with the safety and ethical problems associated with fetal bovine serum (FBS). The primary aim of this study was to compare the effects of human platelet rich fibrin (hPRF) exudate Vs FBS on prolife...

Aims: To evaluate the therapeutic efficacy of azithromycin (azm) and/or metronidazole (mtz) on the histopathological features of rats' gingival overgrowth (GO) induced by cyclosporine-A (CsA) in an animal model. Methods: Ninety male albino rats were divided randomly into six equal groups. The rats of group I received corn oil via gastric feeding...

Several mechanisms have been proposed for revealing the effect of Diabetes on bone healing beginning from reduction of early cellular proliferation, continuing with a delay in bone ossification and ending with a decrease in the biomechanical properties of the newly formed bone. On the other hand, the exact role by which laser irradiation can promot...

Abstract: Objectives: In this study, we evaluated the impact of maternal rheumatoid arthritis (RA) in Albino rats on tooth development in their offspring. Methods: 30 female rats were divided into 2 groups control group (CG), and rheumatoid non-treated group (RhG). Induction of RA was performed in (RhG) by injection of collagen II, followed by indu...

Objectives: Chemotherapy treatments cause dry mouth by damaging the salivary glands. Patients with severely dysfunctional salivary glands often suffer from impaired speech, infection, and loss of taste perception. The development of a non-toxic selective cytoprotective agent that preferentially protects normal tissues from chemotherapy toxicity, wi...

Introduction ooth avulsion is defined as total displacement of the tooth out of its alveolar socket. Replantation of an avulsed tooth is an invasive procedure that requires informed consent of the patient or parent and the cooperation of the patient. The primary aim of any treatment must be to replant an avulsed adult tooth as soon as possible. The...

The cell phone is being used extensively worldwide; its harmful effect on human being is still controversial, especially in diabetic patients exposed to different stresses by modern technology. objective: This study was conducted to assess the biological effect of cell phone radiation on parotid salivary gland' cells in induced diabetic rats by Com...

The increasing interest of mobile phone radiation effect on human health is still controversial. So this study was conducted for detection of Ki-67 antigen as a proliferative marker in the salivary gland that exposed to pulsed EMFs emitted device in different periods. Materials and Methods: Randomized twenty five male guinea pigs were classified in...

The increasing interest of mobile phone radiation effect on human health is still controversial. So this study was conducted for detection of Ki-67 antigen as a proliferative marker in the salivary gland that exposed to EMFs emitted device in different periods. Materials and Methods: Randomized twenty five male guinea pigs were classified into five...

aBsTracT problem statement Osteoporosis is the major health imperative disease requires attention to discover different new therapies. Monascus purpureus NTU 568-fermented red rice (RYR) is used as a traditional hypocholesterolemic dietary food component in Asia that may has anabolic effect on osteoporosis. Objective: The aim of this study was to a...

1Immunohistochemical Expression Of Epithelial Cadherin In The Buccal Mucosa Of Guinea Pigs After Topical Application Of PolicresulenAhmed R Zaher*, Mohamed E Helal*, Mohammed E Grawish* and Walid Zedan***Lecturer, Department of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt.** Lecturer, Department of Oral pathology, Faculty of Denti...

The concern of the osseointegration improvement around titanium was our goal in this study, since surface changes in titanium implant affects the success of osseointegration process. The dental laser has been used for uncovering submerged implants as well as decontaminating implant surface when treating peri-implantitis. So: the aim of this study w...

Sirolimus is a modern immunosuppressive drug that has a novel mechanism of action as it improves the patients' condition receiving transplant. This study aimed to asses the effects of sirolimus Vs cyclosporin A (CsA) immunosuppressive drug on teeth's alveolar bone. Fifteen Mongrel dogs were used in this study. They were classified into three equal...