Mansoura University
  • Al Manşūrah, Egypt
Recent publications
Dietary manipulations play an important role in improving the rabbit behaviour and performance and mitigating the negative effects of heat stress (HS) in rabbits. Thus, this study was designed to determine the modulatory role of thyme essential oil (TEO) in improving the blood metabolites, antioxidant status, immunological response, ovarian activity, reproductive traits and fecundity of rabbit does kept under high environmental stress. A total of 100 nulliparous does were used and randomly assigned into five treatments of 20 does each. The basal diet fed to the experimental groups contained TEO at levels of 0, 50, 100, 150 and 200 mg/kg diet for the 1st, 2nd, 3rd, 4th and 5th groups, respectively. The period of TEO treatment was one month during an experimental period of three months during the summer season. Results showed that TEO at a level of 100 mg/kg diet decreased (p ≤ .001) MDA, while increased (≤.001) total proteins (TPs), albumin (AL), globulin (GL), blood haemoglobin, total antioxidant capacity (TAC), haematocrit (Ht) and glutathione (GSH). Conversely, the TEO treatment did not affect GSH peroxidase and superoxide dismutase (SOD). Immunological variables (IgG and IgM), milk production, ovulation rate (OR) and normal embryos percentage were significantly improved by 100 mg TEO/kg diet supplementation. The reproductive variable of stressed rabbit does fed TEO were significantly higher than those in the control diet. Collectively, dietary TEO supplementation can alleviate the negative influences of heat stressed-female rabbits, via enhancing the antioxidant capacity and immunological parameters. • Highlights • Dietary manipulations play an important role in improving the rabbit behaviour and performance. • Addition of TEO to rabbit diets improved rabbit performance and health as well as reduced the negative effects of heat stress (HS). • Immunological indices and milk production, ovulation rates (ORs) and normal embryos were significantly improved by TEO. • Thyme essential oil (TEO) decreased MDA and increased protein and its fraction, blood haemoglobin and total antioxidant capacity (TAC).
The knowledge of the root nodule microbiome is still beyond the minimum. This study has been designed to isolate and characterize plant growth promoting bacteria and testing their ability to promote plant growth. In addition to Rhizobium MAP7, four other strains have been isolated from Phaseolus vulgaris nodules, and they have been molecularly identified as Bacillus MAP3, Brevibacillus MAP4, Pseudomonas MAP5, and Pseudomonas MAP8. The obtained strains showed the ability to produce IAA, siderophores, and HCN with different capabilities. A pot experiment was conducted to investigate the effect of the obtained strains on the physical growth parameters of Vicia faba. The inoculation with Rhizobium MAP7 along with Brevibacillus MAP4 and Pseudomonas MAP5 led to four times increase in the number of nodules (57/plant) compared with that of the control in addition to a significant increase in the physical growth parameters . Additionally, different nitrogen fractions increased significantly in response to this inoculum (226 and 206 mg/g dry weight total nitrogen for shoot and root respectively compared with 175 and 92.5 for control plants). The obtained strains in this study showed a good potentiality as plant growth promotors that might be tried with further crops on wider scale.
ABSTRACT The present study was conducted to investigate the allelopathic activity of Rumex dentatus aqueous leaf extract on metabolites, reactive oxygen species (ROS), and enzymes activities in Portulaca oleraceae. The results showed a reduction of carbohydrates, protein, DNA, and RNA contents. However, the total phenolics, total flavonoids, and malondialdehyde were enhanced. The ROS such as hydrogen peroxide, superoxide radicals, and hydroxyl radicals were increased in concentration-dependent manner. The activities of glucose-6-phosphate dehydrogenase, 6- phosphoglucnate dehydrogenase, nitrate reductase, and glutamine synthetase were reduced in Portulaca leaves as the concentration of Rumex extract increased; however the activities of NADHoxidase and phenylalanine ammonia-lyase were increased under treatment with the various tested concentrations of Rumex extract. Gas chromatography–mass spectrometry profile of aqueous Rumex extract was performed for the detection of the dominant compounds that may reveal the impact on Portulaca metabolites and enzymes activities
Multifunctional molecules might offer better treatment of complex multifactorial neurological diseases. Monoaminergic pathways dysregulation and neuroinflammation are common convergence points in diverse neurodegenerative and neuropsychiatric disorders. Aiming to target these diseases, polypharmacological agents modulating both monoaminergic pathways and neuroinflammatory were addressed. A library of analogues of the natural product hispidol was prepared and evaluated for inhibition of monoamine oxidases (MAOs) isoforms. Several molecules emerged as selective potential MAO B inhibitors. The most promising compounds were further evaluated in vitro for their impact on microglia viability, induced production of proinflammatory mediators and MAO-B inhibition mechanism. Amongst tested compounds, 1p was a safe potent competitive reversible MAO-B inhibitor and inhibitor of microglial production of neuroinflammatory mediators; NO and PGE2. In-silico study provided insights into molecular basis of the observed selective MAO B inhibition. This study presents compound 1p as a promising lead compound for management of neurodegenerative disease. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
COVID-19 imposed significant limitations upon the 2021 U.S. National Resident Matching Program (NRMP), most important of which is the replacement of traditional in-person interviews with a virtual format. To determine the strengths, limitations, and overall utility of virtual interviews (VIs) for residency applicant selection, a 14-question electronic survey was administered to programme directors (PDs) of all American Council for Graduate Medical Education (ACGME)-accredited residency programmes, from December 2020 through March 2021. PDs were asked about their experience with VIs and the ability to assess residency applicants using the virtual format. A total of 1123 PDs (30% response rate) representing 30 different specialities responded to our survey. Compared to in-person interviews, VIs made it more challenging to assess applicants' fit with the programme, emotional intelligence, commitment to speciality, and ability to function as a resident physician. Overall, only 15% of PDs believed that VIs were better than in-person interviews. Once travel restrictions are lifted and in-person interviews are possible, 67% of PDs plan on hosting dual-format residency interviews, while 26% and 5% of PDs will exclusively host in-person interviews and VIs, respectively. This result was significantly different between surgical and non-surgical programmes [35% of surgical PDs suggested they would offer in-person interviews exclusively, compared to 21% of non-surgical PDs, p < 0.0001]. Although proven to be cost and time-efficient, VIs were challenging in evaluating certain qualities of residency applicants. While this study was focused on U.S. residency matching, it provides important insights about the future of VIs in medical recruitment as a whole.
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Alaa Sabry
  • Urology and Nephrology Center
Alaa el-din mohamed Riad
  • Department of Information Systems
Hesham Abdel-Hady
  • Department of Pediatrics
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President of Mansoura University
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