Mansoura University

Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia. The current study aimed to investigate the potential of empagliflozin (EMPA) to protect against acetylcholine (ACh)/calcium chloride (CaCl2)-induced AF in rats and elucidate the possible underlying mechanism of action. Rats were randomly assigned to five groups, as follows: CTRL group: received 1 ml/kg isotonic saline; AF group: received 1 ml/kg induction mixture of ACh/CaCl2 (60 µg ACh and 10 mg CaCl2 per ml); EMPA group: received 30 mg/kg EMPA; AF + EMPA10 group: received the induction mixture concurrent with 10 mg/kg EMPA; AF + EMPA30 group: received the induction mixture concurrent with 30 mg/kg EMPA. Our results showed that EMPA administration inhibited the AF-related electrocardiographic abnormalities and decreased the serum brain natriuretic peptide levels. EMPA treatment maintained the cardiac redox balance, as indicated by reduced levels of the lipid peroxidation biomarker malonaldehyde while enhancing the antioxidant glutathione levels. Moreover, EMPA markedly repressed ACh/CaCl2-induced C-reactive protein, tumor necrosis factor, and interleukin-6 production. Interestingly, EMPA administration strongly suppressed cardiac transforming growth factor beta1, collagen type I, and alpha-smooth muscle actin expression levels in the AF rats. These results were consistent with our histopathological findings, which revealed the ameliorative effect of EMPA on AF-induced inflammatory and fibrotic lesions. Mechanistically, EMPA dose-dependently downregulated nuclear factor-kappa B (NF-κB) and hypoxia-inducible factor (HIF)-1α expressions. Besides, it attenuated the pro-apoptotic active caspase-3 while augmenting the anti-apoptotic B-cell lymphoma 2 expressions. Furthermore, EMPA dose-dependently suppressed cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling. In conclusion, this study demonstrates that EMPA intervention, within AF induction, protects against ACh/CaCl2-induced AF in rats, exerting powerful antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic effects. These effects are mainly mediated through the targeting of the NF-κB/HIF-1α regulatory axis in a dose-dependent manner.

The stochastic nonlinear Kodama (SNLK) equation forced in the Stratonovich sense by multiplicative noise is considered here. New elliptic, hyperbolic, trigonometric, and rational stochastic solutions are acquired using (G′/G)-expansion method and mapping method. Because the SNLK equation is extensively used in is extensively used in nonlinear optics, fluid dynamics, and plasma physics, the obtained solutions may be used to study a broad range of relevant physical phenomena. In order to interpret the effects of multiplicative noise, the dynamic performances of the various obtained solutions are displayed utilizing 3D and 2D graphs. We infer that multiplicative noise impacts and stabilizes the solutions of SNLK equation.

Couplings exist between power-electronic converters' positive and negative impedances. While such couplings have been considered in many works for stability analysis of grid-forming converters, many other studies have accurately predicted the converter-grid stability with couplings ignored. This paper provides a detailed comparative analysis of the sequence impedance coupling in droop control-based converter (DBC) and virtual synchronous machine (VSM). The impacts of droop gains, virtual inertia, and voltage controllers are mainly outlined. It is shown that the VSM has notably less impedance coupling than the typical DBC, basically due to its virtual exciter's integrator. Additionally, this paper introduces the VSM's impedance coupling saturation phenomenon. The improper design of the VSM's voltage exciter leads to impedance coupling as high as that of the typical DBC, regardless of the virtual inertia. Based on the analysis and the impedance-coupling saturation phenomenon, a simple yet effective control-design-based mechanism is proposed to weaken the impedance coupling in VSM and in a modified DBC with an integrator in its voltage loop. The proposed impedance weakening method eases the converter-grid interactions and stability analysis by deploying the normal Nyquist stability criterion. Detailed time-domain and real-time simulations are carried out under different grid strengths to justify the theoretical analysis.

The pharmaceutical industry has been primarily focused on developing synthetic drugs to address orofacial pain (OFP)-related conditions. There is limited knowledge regarding the efficacy of the use of herbal extracts in treating OFP. A systematic review and a meta-analysis of 62 randomized controlled trials assessing the analgesic effects of herbal extracts on pain intensity in various orofacial conditions was conducted. The intervention comprised the use of herbal extracts compared with a placebo and/or standard treatment. The primary outcome was pain intensity assessed before and after the intervention. The pain scores were compared with the baseline scores in each treatment. When compared with standard therapy, the pooled results of the patients who received herbal extracts revealed lower pain intensity in periodontal pain (MD = -0.92[-6.69, 4.85]), oral surgery pain (MD = 18.80[8.80, 28.79]), oral neuropathic pain (MD = 20.34[6.16, 34.52]), endodontic pain (MD = -8.04[-11.72, -4.37]), oral mucosal pain (MD = 8.74[2.76, 14.73]), and temporomandibular pain (MD = 30.94[6.04, 55.83]). The findings indicated a pain-attenuating effect of herbal extracts such as cannabis, turmeric, capsaicin, licorice, ginger, chamomile, clove, Hypericum perforatum, and Arnica montana. These findings revindicate that herbal extracts may be valuable alternatives to traditional pain medications and promising source for the development of new active ingredients for pharmaceuticals. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-77796-7.

Objective White spot lesions are initial sign of enamel caries that compromise esthetic appearance following orthodontic treatment. Thus, the systematic review was conducted to evaluate the remineralization potential of orthodontic adhesives on early-enamel lesions surrounding orthodontic bracket. Methods Search strategy was performed through three databases (PubMed, Web of Science, and Scopus). A total number of 1712 studies were identified for being potentially relevant, 62 among them were further assessed. Finally, 24 studies were included in this systematic review after adopting the eligibility criteria. The methodologies used to assess enamel remineralization were micro-computed tomography, cross-sectional microhardness, and polarized light microscopy for evaluating remineralization extent; surface microhardness, color change, and laser-induced fluorescence for evaluating superficial surface mineralization; Fourier Transform InfraRed, and Energy Dispersive Spectroscopy technique for chemical characterization. Results Bioactive glass (BAG), nano-hydroxyapatite (n-HAP), nano-amorphous calcium phosphate (n-ACP), nano-calcium fluoride (n-CaF2), fluorinated amorphous calcium phosphate nanoparticles (AFCP), and ammonium-based methacrylate monomer were incorporated into orthodontic adhesives. Seven out of the 24 included studies utilized commercially available orthodontic adhesives. While the remaining studies utilized experimental bioactive adhesives; 13 studies evaluated adhesives containing (BAG), two studies evaluated adhesives containing (n-ACP), one study evaluated adhesives containing (AFCP), and one study evaluated adhesives containing (n-HAP). Orthodontic adhesives containing the previously mentioned additives showed significant remineralization power compared to control group. Majority of studies that evaluated bioactive-based orthodontic adhesives revealed significant remineralization effect in comparison with their corresponding control groups. Out of 24 studies, 8 have assessed ion-release. However, few numbers of included studies evaluated the ion-release peak values. The output of most studies reported a significant increase of ion-release over time. Only one study reported a mark decrease of calcium and phosphate ions after 72 h. Following the high risk of bias in the majority of studies, and lack of standard evaluation protocol, meta-analysis was not conducted. Conclusion The outcome of the included studies supports the effectiveness of incorporation of remineralizing agents into orthodontic adhesives.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related morbidity worldwide. Sorafenib is a first-line drug for the treatment of HCC, however, it is reported to cause serious adverse effects and may lead to resistance in many patients. In this study, 20 hydrazone derivatives incorporating triazoles, pyrazolone, pyrrole, pyrrolidine, imidazoline, quinazoline, and oxadiazine moieties were designed, synthesized, and characterized. In addition to molecular docking and in silico ADME study, the cytotoxic activity of the synthesized compounds was evaluated against the human hepatocellular cancer cell line (HepG2) and liver mesenchymal stem cells as a normal cell line. The antitumor activities of the derivatives against sorafenib were compared. Of the 20 synthesized compounds, compound 16 demonstrated potential as a potent anti-HCC drug candidate through downregulation of interleukin 6 which reduces inflammation and tumorigenesis with a strong binding interaction and bioavailability.

Background and Purpose Narcolepsy is a chronic illness characterized by excessive daytime sleepiness and cataplexy. Recently, sodium oxybate (SXB) has been the only effective drug in treating multiple symptoms of narcolepsy. Our study aims to assess the effectiveness and safety of SXB in treating narcolepsy. Method We searched four databases for eligible studies. Our primary outcome was to investigate the effectiveness of SXB through symptom improvement. For the secondary outcome, we assess its safety through the reported adverse events. Result Five RCTs were included. The SXB group had significantly improved weekly cataplexy attacks better than the placebo (MD = -5.04, 95% CI [-6.35, -3.72], P < 0.00001), also the improvement in the Maintenance of Wakefulness Test, and ESS was better in the SXB group with (MD = 4.66, 95% CI: [2.24, 7.07], p = 0.0002), (MD = -1.93, 95% CI: [-2.73, -1.13], p < 0.00001) respectively. CGI-I was observed to be significantly better in the SXB group with (RR = 2.15, 95% CI: [1.69, 2.73], p < 0.00001). The weekly cataplexy attack was significantly improved by the doses (4.5, 6, and 9 gm) in comparison with the placebo, with the 9-gm dose having the most beneficial effect. The improvements were significant only in SXB 9 gm in ESS and 6 and 9 gm in CGI-I. Conclusion SXB is an effective pharmacological treatment for the management of narcoleptic patients with cataplexy with an acceptable safety profile. Further studies with a large scale are needed to investigate and prove the efficacy and tolerability of SXB.

Purpose This study aimed to determine the association between placental site and successful labor induction. Methods This cross-sectional study recruited all postdate primiparous women undergoing induction of labor. Eligible women were subjected to proper history taking and clinical examination. Vaginal examination to determine the bishop score was done. Routine antenatal scan was done for fetal biometry and the placental site. Transvaginal ultrasound was done for cervical length assessment. Induction of labor was commenced and women were subdivided into those with successful induction (delivered vaginally) and those with failed induction (needed cesarean delivery). Results Successful induction was achieved in 73/91 (80.2%) participants. The bishop score was significantly increased among women with successful induction (4.6 ± 0.9 vs 3.9 ± 1.1, p value 0.014). In addition, the cervical length was significantly shorter among those who delivered vaginally (2.6 ± 0.5 vs 4.2 ± 0.5, p value 0.0001). There was no significant difference in the placental site among women with failed or successful induction. The cervical length was the only significant predictor for successful induction of labor (p value 0.0001). The placental site showed a non-significant role in the prediction of successful vaginal delivery (p value 0.280). Conclusion The placental site is not associated with the outcome of labor induction. The cervical length was the significant predictor for successful induction of labor.

This paper presents design and dynamic performance investigation of a 25kV $\mathbf{25}\,\boldsymbol{k}\boldsymbol{V}$ full‐scale, modular topology (arranged on the sides of a regular hexagon), medium voltage direct current (MVDC) permanent magnet (PM) biased presaturated fault current limiter (PMFCL). This PMFCL represents a cost‐effective design with enhanced longevity, reliability, scalability, and controllability. The scalability of this modular design can be extended by adding or removing CI (letters: CI) core units for different power system applications in a voltage range from 5 $\mathbf{5}$ to 50kV $\mathbf{50}\,\boldsymbol{k}\boldsymbol{V}$ or more. The rated steady‐state (DC) and fault currents of 1kA $\mathbf{1}\,\boldsymbol{k}\boldsymbol{A}$ and 4kA $\mathbf{4}\,\boldsymbol{k}\boldsymbol{A}$, respectively. The detection free and self‐triggering performance of this PMFCL is designed and simulated through a 3D coupled model of electric‐circuit magnetic‐field of COMSOL Multiphysics. Accurate representation of PM behaviour, especially in the second quadrant of its B−H $\boldsymbol{B}-\boldsymbol{H}$ hysteresis loop of Jiles‐Atherton method gives realistic performance of the PMFCL. Comprehensive finite element simulations are carried out to study the effect of design parameters on the dynamic performance of PMFCL. Good agreement is found between COMSOL simulation results of DC‐biased PFCL and experimental results of a developed small‐scale prototype. Results reveal that the MVDC PMFCL shows significant improvement and satisfactory performance, in terms of fault current clipping ratio, fault current slope, and power losses, as compared to the conventional MVDC DC‐biased presaturated CI iron‐core fault current limiter (PFCL).

Background Premarital screening and counseling (PMCS) is a preventive measure for genetic, infectious, and blood-transmitted diseases. This study aimed to assess secondary school students’ knowledge of and attitudes towards PMCS in Taiz City, Yemen. Methods This study included 306 secondary school students selected through stratified random sampling from six secondary schools representing three directorates in Taiz city, Yemen. Researchers used two validated tools, students’ knowledge and attitudes about the PMCS which were adopted from previous studies, to collect the necessary data. The data were analyzed using the SPSS software. Descriptive analysis was conducted for frequencies and percentages while chi square test was used to identify the relationships between the demographics and knowledge level. Results Most of the students had a weak knowledge of 58.82%, while 40.52% showed fair understanding. The majority of students (79.09%) displayed a positive attitude towards PMCS, among the students with a positive attitude, 36.93% had fair knowledge, whereas 41.5% of the students had weak knowledge. Conclusion The study concluded that secondary school students in Taiz lack knowledge and have positive attitudes towards various aspects of premarital screening and counseling. Knowledge deficits were linked to male students, younger academic years, non-engagement, and family history of disease.

Objective To examine the prevalence of imposter syndrome among nursing students and its association with depression, stress, and anxiety. Methods A multi-center cross-sectional survey was conducted with 1572 nursing students randomly selected from three universities across Egypt. The study was conducted over 3 months, from the beginning of January to the end of March, during the academic year 2023/2024. Clance Imposter Phenomenon Scale and Depression Anxiety Stress Scale-21 were used for data collection. Results A significant proportion of nursing students experience moderate to highly severe levels of depression, anxiety, and stress. Around a quarter of students had moderate depression, 22.6% had moderate anxiety, and 14.9% had severe anxiety. Additionally, 13.3% of participants experienced severe stress, with only 3.8% experiencing highly severe stress. The study also found that 46.3% of students experienced moderate imposter syndrome, with 33% having frequent imposter levels and 6.2% scoring intense imposter on the scale. Furthermore, imposter syndrome was positively correlated with depression, anxiety, and stress, and the total score of the Depression Anxiety Stress Scale (r = 0.639, p < 0.001). The stepwise linear regression analysis explained that 45.0% of the variance in students' depression, anxiety, and stress was due to imposter syndrome and other sociodemographic covariates. Conclusion This study highlighted the relationship between imposter syndrome, depression, anxiety, and stress among nursing students. Specifically, female students in higher academic years, with lower grade point averages, living in urban areas, with lower family incomes, and not participating in hobbies are more prone to depression, anxiety, and stress. Nursing implications These findings underscore the need for a holistic approach to managing the complex nature of mental health among nursing students. Incorporating education and resources on self-care and stress management techniques into nursing training programs is imperative for addressing the implications of imposter syndrome in nursing practice. Equipping nursing students with these essential skills can enhance their resilience, foster a healthier work environment, and ultimately improve patient care outcomes.

Background Primary tooth wear is a common phenomenon that affects chewing ability, dental sensitivity, aesthetics, and occlusion. This study was conducted to compare the antagonistic enamel wear of primary molars opposed to four different crown materials. Methods Forty lower second primary molars of children aged 4–8 years were allocated into 4 groups: Group 1 (n = 10): received stainless steel crowns; Group 2 (n = 10): received prefabricated commercially available zirconia crowns (NuSmile®); Group 3 (n = 10): received locally manufactured zirconia crowns created via the CAD/CAM system; and Group 4 (n = 10): received locally manufactured hybrid ceramic (Vita Enamic®) crowns created via the CAD/CAM system. All the crowns were cemented with resin-modified glass ionomer cement. The upper arch was scanned with a 3D intraoral scanner immediately (baseline), 6 months, and 1 year after crown cementation to evaluate the wear of the natural enamel of the antagonistic primary molar. The resultant scans were compared via Exocad software to measure the amount of linear wear of the mesiopalatal cusp of the primary upper second molar. Results The analysed data revealed statistically significant differences between the studied groups. The highest mean wear was detected in the CAD/CAM zirconia crown group, followed by the NuSmile zirconia crown group and then the CAD/CAM hybrid crown group, and the lowest mean wear was detected for the stainless-steel crown group. Conclusion Compared with stainless steel crowns, aesthetic crowns cause more wear in the antagonistic primary molar enamel. CAD/CAM zirconia crowns induce the greatest amount of wear, followed by NuSmile zirconia crowns. The CAD/CAM hybrid crown is an aesthetic tooth-coloured crown that causes less wear of the opposing enamel than zirconia crowns do. Trial registration The ClinicalTrials.gov Protocol Registration and Results System (PRS) has this RCT registered as (NCT06456879) on 07/06/2024.

An innovative voltammetric sensor was developed to estimate omarigliptin, a novel long-acting anti-diabetic drug. The sensor utilized a carbon paste electrode enhanced with a nanocomposite of carbon nanotubes and electrodeposited gold nanoparticles. The modified electrode was characterized using scanning electron microscopy and electrochemical impedance spectroscopy. The modification significantly improved the electrode’s sensitivity and electrochemical efficiency and decreased its electron transfer resistance. The surface area of the modified electrode increased by about 2.8-fold compared to the bare electrode. Omarigliptin’s oxidation behavior on the modified electrode was pH-dependent and irreversible, resulting in a peak current 4 times higher than the unmodified electrode. The modified electrode revealed good reproducibility, reusability, and stability. It allows for sensitive voltammetric analysis of omarigliptin over a linear range of 0.4–27 μM (LOD = 0.12 μM) and good applicability in tablets and plasma. The recovery percentages were 98.47%–101.27% in tablets and 95.86%–105.02% in plasma. The modified electrode exhibits good selectivity towards omarigliptin without interference from tablet excipients, endogenous plasma components, and co-administered drugs. The comparison with the reported methods reveals the superiority of the proposed method in terms of sensitivity, selectivity, applicability, and eco-friendliness. Finally, the proposed method demonstrates excellent environmental profiles based on recent assessment metrics.

Asphalt pavements are consistently subjected to environmental and loading conditions that affect their durability, such as oxidative aging. Modification of the pavements assists in reducing the aging-induced stiffness. One of these solutions is crumb rubber (CR)-modified warm mix asphalt (WMA) binders. This study aims to assess the long-term performance and effects of aging on CR-modified WMA binders through a series of physical, rheological, and chemical tests. 2% and 4% of Sasobit, a wax-based additive, and 1.5% and 3% of Zycotherm, a nano-based chemical additive, with 10%, 15%, and 20% CR, were utilized. The binders were aged using a rolling thin film oven (RTFO) and pressurized aging vessel. The unaged and long-term aged asphalt binders were tested. Rheological properties, using master curves and zero shear viscosity, physical properties measured through elastic recovery, along with chemical analysis using Fourier transform infrared (FTIR) spectroscopy, were carried out on the binders before and after aging. Based on the physical and rheological aging indices, Sasobit-modified asphalt binders exhibited superior resistance to aging and rutting compared to Zycotherm-modified binders. Specifically, the Sasobit 4% and 20% crumb rubber blend showed the highest resistance to physical aging, while Zycotherm-modified binders demonstrated improved chemical aging resistance. Adding crumb rubber significantly enhanced the stiffness and elasticity of the asphalt binders, further reducing the effects of aging. FTIR analysis confirmed that Sasobit and crumb rubber reduced oxidation and volatile component loss during aging.

The North Kuwait region has been facing with a range of challenges related to inconsistent drilling downtime and varying sealing conditions caused by abnormal pore pressure. In order to address these issues effectively, a comprehensive analysis was conducted using image logs, well cores, and seismic data collected from 23 wells in the Sabriyah field and 35 wells in the Raudhatain field. The primary objective was to improve drilling efficiency and well completion, identify key structural phases and fault orientations, evaluate the relationships between fractures and other structural elements, gain valuable insights into fractures and stress conditions, and optimize reservoir management to enhance productivity and efficiency. It was observed that open fractures in both the Sabriyah and Raudhatain fields align predominantly in a northeast-southwest direction. This alignment significantly increases storage capacity, improves permeability, and facilitates the implementation of more efficient hydraulic fracturing techniques. The dominant alignment of fractures in the north-northeast direction, which aligns with the present-day orientation of the maximum principal stress, has a distinguished impact on well perforation and subsequent efforts to enhance production. However, the presence of cemented fractures filled with calcite and organic matter has the potential to impede production rates, particularly in over-pressured reservoirs. Formation micro-imager (FMI) logs have proven to be vital in identifying drilling-induced tensile fractures. These logs provide insights into the structural history, geomechanical properties, and overall stability of the wellbore. The discrepancy in fault occurrences between the Sabriyah and Raudhatain fields highlights the heightened complexity encountered during drilling operations in the Sabriyah field, where faults are more frequent compared to the Raudhatain field. A 1D geomechanical model facilitates the adoption of strategic drilling operations, enhances the evaluation of reservoir risks, and ultimately elevates overall operational efficiency. The available data presents important information regarding the geomechanical attributes and the influence of natural fractures on reservoir efficacy. A successful approach encompasses the application of horizontal or directional wells, hydraulic fracturing methods, and customized designs for drilling fluid and cement slurry. Furthermore, it is crucial to consider optimal perforation positions in fractured carbonate reservoirs to achieve optimal well positioning.

Decision-making in many industries relies heavily on accurate forecasts, including the insurance sector. The Social Insurance System (SIS) in Egypt, operating under a fully funded paradigm, depends on reliable predictions to ensure effective financial planning. This research introduces a hybrid predictive model that combines fuzzy time series (FTS) Markov chains with the tree partition method (TPM) and difference transformation to forecast total pension benefits within Egypt’s SIS. A key feature of the proposed model is its ability to optimize the partitioning process, resulting in the creation of nine intervals that reduce computational complexity while maintaining forecasting accuracy. These intervals were consistently applied across all fuzzy time series models for comparison. The model’s performance is evaluated using established metrics such as MAPE, Thiels’ U statistic, and RMSE. Additionally, prediction interval coverage probability (PICP) and mean prediction interval length (MPIL) are used to assess the quality of prediction intervals, with a 95% prediction interval serving as the baseline. The proposed model achieved a PICP of approximately 95%, indicating well- calibrated prediction intervals, although the MPIL of 424.5 reflects a wider uncertainty range. Despite this, the model balances coverage accuracy and interval precision effectively. The results demonstrate that the proposed model significantly outperforms traditional models like linear regression, ARIMA, and exponential smoothing and conventional FTS models like Song, Chen, Yu, and Cheng by achieving the lowest MAPE with the value of 11.8% for training and 10.65% for testing. This superior performance highlights the model’s reliability and potential applicability to further forecasting tasks in the field of insurance and beyond.

Recommendation Systems (RS) play a crucial role in delivering personalized item suggestions, yet traditional methods often struggle with accuracy, scalability, efficiency, and cold-start challenges. This paper presents the HRS-IU-DL model, a novel hybrid recommendation system that advances the field by integrating multiple sophisticated techniques to enhance both accuracy and relevance. The proposed model uniquely combines user-based and item-based Collaborative Filtering (CF) to effectively analyze user-item interactions, Neural Collaborative Filtering (NCF) to capture complex non-linear relationships, and Recurrent Neural Networks (RNN) to identify sequential patterns in user behavior. Furthermore, it incorporates Content-Based Filtering (CBF) with Term Frequency-Inverse Document Frequency (TF-IDF) for in-depth analysis of item attributes. A key contribution of this work is the innovative fusion of CF, NCF, RNN, and CBF, which collectively address significant challenges such as data sparsity, the cold-start problem, and the increasing demand for personalized recommendations. Additionally, the model employs N-Sample techniques to recommend the top 10 similar items based on user-specified genres, leveraging methods like Cosine Similarity, Singular Value Decomposition (SVD), and TF-IDF. The HRS-IU-DL model is rigorously evaluated on the publicly available Movielens 100k dataset using train-test splits. Performance is assessed using metrics such as Root Mean Squared Error (RMSE), Mean Absolute Error (MAE), Precision, and Recall. The results demonstrate that the HRS-IU-DL model not only outperforms state-of-the-art approaches but also achieves substantial improvements across these evaluation metrics, highlighting its contribution to the advancement of RS technology.

Copper-nickel alloys are the preferred material for desalination facilities and condensers and heat exchangers that use saltwater as a coolant. The eco-friendly compounds especially Carob fruit extract (CFE) has emerged as excessive green corrosion inhibitor for alloys. Cu-Ni alloys are widely used in various industries due to their excellent corrosion resistance. However, their performance can be compromised in aggressive environments like seawater (which is approximately 3.5% NaCl). To evaluate the corrosion behavior of these alloys and the effectiveness of corrosion inhibitors, researchers often employ weight loss, potentiodynamic polarization, and impedance spectroscopy techniques. The results showed that CFE exhibited a good ability to decrease the CR of alloys in 3.5% NaCl solution. The inhibition efficacy (IE) was reached to 92.6% and ̴ 83.2% at 300 ppm dose of CFE for Cu-10Ni alloy and Cu-30Ni alloy, respectively. The CR increases with temperature rising, but the addition of CFE reduces the CR, and the reduction depends on the dose of the extract. Adsorption of the extract gives a good fit to Langmuir, Temkin, and Freundlich isotherms model. The free adsorption energies of CFE on Cu-10Ni and Cu-30Ni alloys were 17.61 and 15.86 kJ mol⁻¹, respectively, suggesting that CFE was weakly held to both alloys. The presence of a protective film on the alloys surface is confirmed by using scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy and atomic force microscope (AFM). The study suggests that utilizing affordable, natural substances as green corrosion inhibitors presents a new strategy for promoting both resource efficiency and environmental sustainability.

We focus specifically on the rare occurrence of cardiac thrombi in Li-Fraumeni syndrome (LFS). LFS is a hereditary risk to a diverse range of specific, uncommon, malignancies. Children and young adults have a heightened susceptibility to many malignancies, particularly soft-tissue and bone tumors, breast malignancies, central nervous system malignancies, adrenocortical carcinoma, and blood cancers. Additionally, LFS patients may experience other cancer types such as gastrointestinal, lung, kidney, thyroid, and skin cancers, along with those affecting gonadal organs (ovaries, testicles, and prostate). An accurate diagnosis of LFS is crucial to enable affected families to access appropriate genetic counseling and undergo surveillance for early cancer detection.