Marlina OLYISSA Córdoba Moreno

University of São Paulo | USP · Departamento de Fisiologia Geral (IB) (Sao Paulo)

Immune‐pineal axis activation is part of the assembly of immune responses. Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in macrophages by mechanisms dependent on nuclear factor‐κB (NF‐κB) activation. Cytokines activating the Janus kinase/signal transducer and activator of transcription (STAT) pathways, such...

Key points: -Immune-pineal axis unbalance is observed in early-phase rheumatoid arthritis development. -Only resistant animals present a positive association between adrenal/pineal hormones. -The aMT6s/CORT ratio is decreased in animals that developed rheumatoid arthritis. -The inflammatory score combining the levels of nocturnal IL-1b, MCP-1, IL-...

Synopsis Pathogen-associated molecular patterns modulate melatonin (MEL) production in the pineal and extra-pineal sites and corticosterone (CORT) synthesis in the adrenal/interrenal and other tissues. Both MEL and CORT play essential and complex immunomodulatory roles, controlling the inflammatory response. Given that most of what we know about th...

Microglia, the sentinels of the central nervous system, are responsible for the surveillance and the innate defense against pathogen or danger/damage-associated molecular patterns. The response is fine-tuned to restrain pro-inflammatory responses, preserving neighboring cells. At the injured area, microglia temporarily shift to a pro-inflammatory p...

The pandemic dissemination of the SARS-CoV-2 led, on the one hand, to a worldwide effort to develop mechanistic-based therapeutics and vaccines, and on the other hand, the searching for determining the spreaders and the mechanisms of transmission. Melatonin, a multitask molecule, orchestrates defense responses by allowing the proper mounting, durat...

Daily oscillation of the immune system follows the central biological clock outputs control such as melatonin produced by the pineal gland. Despite the literature showing that melatonin is also synthesized by macrophages and T lymphocytes, no information is available regarding the temporal profile of the melatonergic system of immune cells and orga...

Sepsis constitutes one of the major causes of death in intensive care units. In sepsis induced by Gram-negative, while LPS initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a septic shock, it is also capable of inducing refractoriness to subsequent challenge with LPS, a state kno...

Sepsis constitutes one of the major causes of death in intensive care units. In sepsis induced by Gram-negative, while LPS initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a septic shock, it is also capable of inducing refractoriness to subsequent challenge with LPS, a state kno...

The ability of Mycobacterium tuberculosis (Mtb) to persist in its human host relies on numerous immune evasion strategies, such as the deregulation of the lipid metabolism leading to the formation of foamy macrophages (FM). Yet, the specific host factors leading to the foamy phenotype of Mtb-infected macrophages remain unknown. Herein, we aimed to...

Correlation between cholesterol levels and different cytokines present in TB-PE. Correlation analysis between the levels of IL-6, IL-1β, TNF-α, or IFN-γ and the cholesterol content found in individual preparations of TB-PE (n = 23–24).

Signal transducer and activator of transcription 3 (STAT3) activation enhances lipid bodies accumulation by TB-PE. (A) Immunoblot images of p705-STAT3, STAT3, and β-actin (left panel); quantification of p705-STAT3 vs STAT3 on macrophages treated or not with Static (20 µM) or cucurbitacin (100 nM) for 2 h and then exposed or not to TB-PE for 24 h (r...

Interleukin-10 (IL-10) promotes lipid bodies’ accumulation in TB-PE-treated macrophages. (A) TB-PE were incubated with neutralizing antibodies for 1 h (4°C) for the depletion of IL-10, IL-6, IL-1β, or TNF-α, and then, Protein G Sepharose beads were added and incubated for 1 h (4°C). Finally, TB-PE was centrifuged at 12,000 × g to remove antibody-be...

All-trans-Retinoic Acid (ATRA) is a derivative of vitamin A with anti-proliferative properties. Endotoxin shock and subsequent immunosuppression (IS) by lipopolysaccharide (LPS) stimulates myelopoiesis with expansion of myeloid-derived suppressor cells (MDSC). Since we have previously shown that ATRA reverses the IS state by decreasing functional M...

In this work we show the results of ministacks of direct ethanol fuel cells (DEFC) at 25 o C. Result obtained with a passive DEFC using 2 mgPtRu/C in anodes and 3 mg of Pt in cathodes, when the alcohol concentration was 1 M, showed a power density equal to 0.875 mWcm ⁻² for electrodes with area equal to 25 mm ² . Results related with Nafion content...