Luisa Elsiabeth Katharina Kern

Johannes Gutenberg-Universität Mainz | JGU · Abteilung Klinische Psychologie und Psychotherapie

Diabetic retinopathy (DR) results in vascular damage and impaired neuronal function. Proliferative DR (PDR) is characterized by hypoxia and subsequent neovascularization, yet the resulting impact of these events on retinal function is unknown. Currently, the only therapeutic intervention in PDR is the delay of neovascularization, achieved by photoc...

Der DPP4-Inhibitor Linagliptin wird zur Behandlung von Typ-2-Diabetes eingesetzt. Vorherige Arbeiten unserer Gruppe konnten einen Schutzeffekt auf das mikrovaskulare Gefassystem der diabetischen Retina zeigen. Ziel dieser Studie war die Untersuchung der antiangiogenen Wirkung von Linagliptin im Tiermodell der Fruhgeborenen-Retinopathie (ROP). Die Q...

Question: Methylglyoxal (MG) is a highly reactive glucose metabolite and modifies both protein and DNA leading to an upregulation of many inflammatory and tissue-injury-provoking molecules. It therefore has an important role in the development of diabetic complications such as diabetic retinopathy, whereas its exact role yet needs to be demonstrate...