Ivana Pavić

University Clinical Hospital Center "Sestre Milosrdnice" · Department of Pathology

Background Epidemiological studies suggest an inverse association between H. pylori infection/exposure and inflammatory bowel disease prevalence/incidence, however, there are no reports of individual patients who developed a "non-transient” ulcerative colitis (UC) following H. pylori eradication. Case presentation We report a case of a 72-year-old...

Bullous pemphigoid (BP) is an autoimmune disorder which is usually chronic, with blistering that predominantly affects the skin and occasionally the mucosa, and which includes several different types. One of them is a very rare dyshidrosiform type which is localized on the hands and feet with small or large blisters on the palmoplantar surfaces. BP...

Widely accepted prognostic factors like lymph node status, tumor size and cell differentiation sometimes are not useful in oral cancer diagnostics and prognosis. Therefore, study of tumor heterogeneity which involves also molecular markers might be useful in order to explain mechanisms of appearance and recurrences of oral squamous cell cancer. The...

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract and are generally asymptomatic. A 39-year-old female patient was hospitalized in 2012 at Clinical Department of Internal Medicine, Sestre milosrdnice University Hospital Center, for a focal hypodense irregular circular lesion located in segment III...

OBJECTIVE OF THE STUDY: Connexins are family of transmembrane proteins that build channels in gap junctions. Gradual loss of functional gap junctions and membranous connexin expression during colorectal carcinogenesis was shown. As we earlier found, there is no difference of connexin 43 (Cx43) expression between high and low grade adenomatous polyp...

Celiac disease (CD) and inflammatory bowel diseases (IBD) are separately well-described entities, but the co-occurrence in children has been very rarely reported until today. According to the literature, this case about 12-year-old girl would be the fifth case ever published about co-occurrence in children. We presume that there should be a higher...

Uvod: Mnogi lijekovi prepoznati su kao hepatotoksični i mogu uzrokovati DILI (drug induced liver injury, idiosyncratic liver injury). Toksičnost obično nije predvidiva niti ovisna o dozi. Najčešće se opisuju acetaminophen, antimikrobni i antikonvulzivni lijekovi te kemoterapeutci. Tek nedavno kortikosteroidi su prepoznati kao potencijalno hepatotok...

Uvod: Nealkoholna masna bolest jetre (NAFLD) jedan je od vodećih javnozdravstvenih problema današnjice koji se tradicionalno vezuje uz pretilost, šećernu bolest tip-2 i hiperlipidemiju. Rastući je broj znanstvenih dokaza kako nezdrave prehrambene navike i stil života, od kojih se najčešće spominje neumjerena konzumacija slatkih pića, mogu dovesti d...

Uvod: Istovremena pojava celijakije i ulceroznog kolitisa u jednog djeteta izuzetno je rijetka pojava. Prema literaturi, zasad postoje samo četiri takva opisana slučaja. U ovom prikazu opisujemo slučaj Dvanaestogodišnjakinje s navedenim komorbiditetom. Prikaz bolesnika: Djevojčica je primljena na Kliniku zbog proljeva u trajanju od 3 tjedna. Žalil...

UVOD: Mnogi lijekovi prepoznati su kao hepatotoksični i mogu uzrokovati DILI (drug induced liver injury, idiosyncratic liver injury). Toksičnost obično nije predvidiva niti ovisna o dozi. Najčešće se opisuju acetaminophen, antimikrobni i antikonvulzivni lijekovi te kemoterapeutci. Tek nedavno kortikosteroidi su prepoznati kao potencijalno hepatotok...

Mijelolipom je rijedak, dobroćudan, nefunkcionalni tumor, najčešće smješten u kori nadbubrežne žlijezde. Sastoji se od zrelog masnog tkiva s komponentama hematopoetskog tkiva u različitom omjeru. Postoje stanovite nedoumice vezane uz dijagnosticiranje i liječenje mijelolipoma pa je zbog toga važno sagledati sve aspekte te lezije i okolnosti u kojim...

Aim To assess the frequency and forms of pulmonary tu-berculosis at autopsy in a high-traffic hospital in the capital city of a country with a low tuberculosis incidence. Methods We performed a retrospective search of autopsy data from the period 2000 to 2009 at Sestre Milosrdnice University Hospital Center, Zagreb, Croatia. We also exam-ined patie...

Alport syndrome (AS) was first described in 1927 as hereditary disorded characterized by a combination of nephritis and deafness (1). AS is basement membrane disease affecting approximately 1 in every 5,000 people maifested with juvenile to adult onset progressive glomerulonephritis (2). Two forms have been recognized; dominant X-linked and recesiv...

Liver disease associated with diabetes mellitus (DM) is common and usually takes the form of simple steatosis or nonalcoholic steatohepatitis (NASH). Harrison et al in 2006 described changes in liver biopsies in insulin-dependent diabetes mellitus, characterized by dense perisinusoidal fibrosis not necessarily located in a zonal pattern, thickening...

Lung carcinomas at the time of diagnosis in the majority of cases are inoperabile. Small biopsies are seldom made and rarely diagnostic. Cytology remains the sole tissue disgnostic. Therefore, it is important to perform cyto-patohistologic correlation whenever is possible. A retrospecitve cross sectional study of 2,600 consecutive bronchoscopies an...

Background: Palmoplantar pustular psoriasis is a rare, chronic dermatosis characterized by sterile pustules that develop within areas of erythema and scaling on the palms, soles or both. The minority of patients have chronic plaque psoriasis elsewhere. Focal infections and stress have been reported as triggering factors. Smoking aggravates the dise...

Intrathyroidal parathyroid carcinoma is extremely rare clinical entity with potentially multiple diagnostic pitfalls. We report a case of 40-year-old man presented with classical manifestations of primary hyperparathyroidism, severe hypercalcemia and profoundly increased serum parathyroid hormone level. Neck ultrasonography demonstrated multinodula...

Lichen planus (LP) is an inflammatory condition of the skin but can also affect the mouth and genital region. Oral lichen planus (OLP) may occur on its own or in combination with LP of the skin or genitals. It is thought to affect 1 to 2% of the population. Typically it affects middle-aged and elderly women although it can affect men, and rarely ch...

Cutaneous osteoma (CO) is a rare entity with only scattered cases reported in the literature. Cutaneous ossifications is divided into primary and secondary CO. Secondary CO account for 85% of cutaneous ossifications and develop within preexisting neoplastic or inflammatory skin lesions. Primary CO account for about 15% of cutaneous ossifications an...

– Th e morphological spectrum of gallbladder carcinoma is broad and variable. Most of these tumors are tubular adenocarcinomas. Th ere are some tumors with unusual morpho-logy that may be diffi cult to classify due to their rarity. One of such tumors is the signet-ring cell carcinoma, which is a highly aggressive, mucin producing variant of gallbla...

AIM: Gastric antral vascular ectasia (GAVE) is disorder not so common by occurrence with set of microscopic and/or endoscopic appearances of gastric mucosa. Although etiology and associations are not fully understood, pathogenesis of GAVE could represent prolapse of mobile mucosa through pylorus. Most cases are idiopathic while reminders are second...

The present study was designated to analyze correlation between the presence and extent of peritumoral retraction clefting and various clinicopathologic features in esophageal squamous cell carcinoma (ESCC), and to possibly establish the significance of this phenomenon in ESCC. Fifty-four consecutive patients with advanced ESCC were included in the...

Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial renal disease of a still unknown etiology, associ-ated with an increased frequency of urothelial carcinoma, particularly of the upper urinary tract (UUT). The aim of the study was to compare the occurrence of UUT carcinomas between Brodsko-Posavska Region (BPR) which is the region wit...

Apocrine carcinomas represent a rare group of tumors with a potential for destructive local invasion, regional and distant metastases, and are equally common in both sexes. A case of a 79-year-old woman with axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia is presented. To our knowledge, this is the first...