Hrishikesh D Pai

Lilavati Hospital and Research Centre · Gynecology & ART

Background: Sequential embryo transfer is when both cleavage-stage embryo is transferred on day 3 and blastocyst is transferred on day 5, sequentially in the same cycle. This has been suggested for increasing embryo implantation rate. Sequential transfer gives benefit of both day 3 as well as day 5 transfer in the same cycle, giving better outcome...

Oocyte cryopreservation is a boon for women undergoing assisted reproductive technology. With the evolution in the technique of cryopreservation over the last three decades, there has been an exponential rise in the number of oocyte cryopreservation cycles for diverse indications. Apart from cancer patients, it has also been promoted as a mode of f...

Objectives The objectives of the study were to analyze the prevalence of coronavirus disease (COVID) real-time polymerase chain reaction (RT-PCR) positivity among asymptomatic patients undergoing infertility treatment. Materials and Methods This was an observational study done in five centers in five different cities in India, analyzing the preval...

Background: Azoospermia is a highly evolving subject in the last few decades. In the past, use of donor sperm was the only option providing a realistic chance of conception for couples affected by azoospermia. Introduction of sperm retrieval techniques and assisted reproductive technologies, especially intracytoplasmic sperm injection (ICSI), has...

Background: Oocyte Cryopreservation has become an important part of infertility treatment for various reasons such as fertility preservation in women going for oncological treatment; in oocyte donation cycles; in eliminating several religious, ethical, and legal concerns of embryo freezing and in women who wish to delay childbirth. The newer ”vitri...

Despite considerable advances in the field of in vitro fertilization (IVF), embryo implantation and pregnancy rates have plateaued globally. Thus, much of current research focus is on embryo and endometrial assessment. Day 3 embryo transfers (ETs) have been the standard of practice for long. However, development of blastocyst culture media has led...

Aim: To compare reproductive outcomes of day 2 and day 3 embryo transfer (ET). Materials and methods: In this retrospective records study, all couples who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and ET cycles at Lilavati Hospital & Research Centre over a period of 1 year were studied. Data were collected and a...

Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy.

Surveillance 2016 serves as a record and an overview of the practice, policies and activities associated with assisted reproductive technology (ART) as it existed globally, at the end of 2015. It also, provides an evaluation of specific national and global trends over time that concern specific, and sometimes controversial, topics and issues. Howev...

The purpose of this study was to critically evaluate the effect of sequential embryo transfer in randomized patients undergoing assisted in vitro conception. A randomized prospective study was conducted and the outcomes of 505 patients were analyzed, of which 107 women underwent sequential embryo transfer on day 3 and day 5 (D3/D5 group), 283 women...

In a rapidly advancing era of science, we are witnessing inventions of new drugs with discovery of newer applications. GnRH agonists are one of the good examples of the same. The short half-life of native GnRH triggered the need for more stable and long-acting molecules with similar actions and effects. That was subsequently achieved by the modific...

Polycystic ovary syndrome (PCOS) is a polygenic, multifactorial heterogeneous disorder of uncertain etiology. It is one of the most common endocrine disorders affecting females. The prevalence of PCOS is around 6–8 % in reproductive age group females. PCOS remains an enigmatic disorder, the etiology of which is still unclear. The evidence that PCOS...

Surveillance is a triennial worldwide compendium of national rules and regulations for assisted reproductive technology. It was last published in 2010.

Assisted reproductive technology (ART) has grown by leaps and bounds in the last few years. India has one of the highest growths in the ART centers and the number of ART cycles performed every year. Very soon India will be the leader in the world of ART in terms of a number of cycles. With the advances of technology and availability of techniques e...

Aim The aim of this case-control study was to compare the efficacy of highly purified human menopausal gonadotropin (HPhMG) vs recombinant follicle stimulating hormone (r-FSH) treatments following GnRH agonist suppression in patients undergoing intracytoplasmic sperm injection (ICSI) with moderate male factor infertility in terms of oocyte and embr...

Pregnancy due to its generalized edematous state is known to have a difficult airway. Preeclampsia makes this difficult airway more difficult and if its coupled with HELLP syndrome which becomes anesthetic's worst nightmare. We managed a similar case in our hospital, with multisystem involvement, for an emergency cesarean section. Surgery was carri...

To assess reproductive performance in women with septate uterus and otherwise unexplained infertility after hysteroscopic metroplasty. A total of 72 women with septate uterus and otherwise unexplained primary infertility were included in the study. All of the women underwent hysteroscopic septal resection. Reproductive performance of these women wi...

Research in India is evolving at a rapid pace. Ergo, we need faster approval processes and review timelines. Improvement in the quality of institutional review boards would also contribute to good research practices. Clinical research should be included as a part of the undergraduate medical and pharmacy curriculum, and leading hospitals and practi...

This study was conducted to determine the efficacy of using the technique of intracytoplasm morphologically selected sperm injection (IMSI) as compared to the conventionally used intracytoplasmic sperm injection ((ICSI) procedure. IMSI, as the name suggests, is the technique of selecting the most normal looking sperm by magnifying it to about 7200...

Objective To study the perinatal outcome after fetal reduction in multiple gestations Materials and Methods This is a retrospective study of 12 patients who underwent fetal reduction for multiple gestations. The ultrasound-guided procedure was done transabdominally. Results Of the 12 patients who underwent fetal reduction, one had spontaneous abo...

Objective: To study the incidence of spontaneous abortions, congenital malformations, neonatal and maternal hypoglycemia after metformin therapy in pregnancy. Design: Prospective study. Setting: Outpatient. Patient(s): 56 women previously oligomenorrheic, nondiabetic women with polycystic ovarian syndrome, who conceived while on metformin. Interven...

Background There have been numerous advances in the area of assisted reproduction. Among the various reasons of implantation failure, intrauterine lesions play an important role. Objective The aim of the present study is to evaluate the role of hysteroscopy prior to any assisted reproductive technique in patients who had previous one or more faile...

There have been numerous advances in the area of assisted reproduction. Among the various reasons of implantation failure, intrauterine lesions play an important role. The aim of the present study is to evaluate the role of hysteroscopy prior to any assisted reproductive technique. It is a retrospective study of 292 women who attended our infertili...

There is enough evidence in the literature to support that removal of septum improves pregnancy rates in women with bad obstetric history. However, its role in patients with otherwise unexplained infertility is still not clear due to paucity of enough evidence. To assess reproductive performance in women with septate uterus and otherwise unexplaine...