Helmi SulaimanUniversity of Malaya | UM · Infectious disease unit
Helmi Sulaiman
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Publications
Publications (29)
| Background |
Recent studies found white coats to be reservoirs for bacteria and medical students did not conform to proper hygiene measures when using these white coats. We investigated the knowledge, attitude, and practice (KAP) of medical students toward white coat use in clinical settings (LAUNDERKAP).
| Methods |
A validated, online-based...
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Optimal antibiotic therapy for critically ill patients can be complicated bythe altered physiology associated with critical illness. Antibiotic pharmacokineticsand exposures can be altered driven by the underlying critical illnessand medical interventions that critically ill patients receive in the intensivecare unit. Furthermore, pathogens that ar...
Background
: Medical students’ white coats were found to harbour harmful organisms. This could be due to non-compliance to white coat hygiene measures. Therefore, we aim to develop and validate a questionnaire to assess the of knowledge, attitude, and practice (LAUNDERKAP) of white coat use among medical students in Malaysia.
Methods
: This study...
Background & Objectives: Healthcare-associated Meningitis and/or Ventriculitis (HCAMV) is a serious yet frequent complication following neurosurgery. In this study, the clinical outcomes of HCAMV, risk factors associated with the clinical outcome, etiological agents and their corresponding antibiogram were investigated. Methods: All HCAMV patients...
Introduction:
Approach to managing infection in the intensive care unit (ICU) often varies between institutions and not many readily adapt to available local guidelines despite it was constructed to suite local clinical scenario. Malaysia already has two published guidelines on managing infection in the ICU but data on its compliance are largely u...
Fosfomycin (FMT) was first isolated in 1969 and has gained popularity in the past few decades, specifically in the treatment of uncomplicated urinary tract infection (UTI). A retrospective study was undertaken to study the pattern of FMT use in our outpatient clinics. Subjects were divided into guideline compliant (GC) and non-guideline compliant (...
Fosfomycin (FMT) was first isolated in 1969 and has gained popularity in the past few decades, specifically in the treatment of uncomplicated urinary tract infection (UTI). A retrospective study was undertaken to study the pattern of FMT use in our outpatient clinics. Subjects were divided into guideline compliant (GC) and non-guideline compliant (...
Background:
β-Lactamase resistance among certain Gram-negative bacteria has been associated with increased mortality, length of hospitalization, and hospital costs.
Aim:
To identify and critically appraise existing clinical prediction models of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-EKP) infection or colonization.
Meth...
Background
Tenofovir disoproxil fumarate ( TDF ) is the recommended first‐line nucleoside reverse transcriptase inhibitor ( NRTI ) in the management of human immunodeficiency virus ( HIV ); however, its use is associated with nephrotoxicity.
Aim
To assess if the risks of renal impairment were similar in treatment‐naïve compared to treatment‐experi...
Objectives:
In a clinic-based, treated HIV-infected cohort, we identified individuals with sarcopenia and compared with age, sex and ethnically matched controls; and investigated associated risk factors and health outcomes.
Design:
Sarcopenia (age-related muscle loss) causes significant morbidity to the elderly, leading to frequent hospitalizati...
Hospital-acquired pneumonia and ventilator-associated pneumonia continue to cause significant morbidity and mortality. With increasing rates of antimicrobial resistance, the importance of optimizing antibiotic treatment is key to maximize treatment outcomes. This is especially important in critically ill patients in intensive care units, in whom th...
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is an established pathogen that causes hospital- and community-acquired infections worldwide. The prevalence rate of MRSA infections were reported to be the highest in Asia. As there is limited epidemiological study being done in Malaysia, this study aimed to determine the preva...
There are 50-100 million dengue infections each year, but dengue encephalitis is relatively uncommon. The aetiology of neuronal injury is proposed to be due to direct viral neurotropism or host immune response-mediated inflammation causing neuronal damage. We report a case of severe dengue encephalitis, presenting during the acute viraemic phase of...
Objectives:
Human papillomavirus (HPV)-associated cancers disproportionately affect those infected with HIV despite effective combination antiretroviral therapy (cART). The primary aim of this study was to quantify HPV16 and HPV52 E6-specific interferon (IFN)-? enzyme-linked immunospot (ELISPOT) T-cell responses, a correlate of protective immunity...
Purpose:
This study aims to determine if continuous infusion (CI) is associated with better clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent bolus (IB) dosing in critically ill patients with severe sepsis.
Methods:
This was a two-centre randomised controlled trial of CI versus IB dosing of beta-lactam antibi...
Doripenem has been recently introduced in Malaysia and is used for severe infections in the intensive care unit. However, limited data currently exist to guide optimal dosing in this scenario. We aimed to describe the population pharmacokinetics of doripenem in Malaysian critically ill patients with sepsis and use Monte Carlo dosing simulations to...
We report the first case of an immunocompromised adult patient presenting with cervicofacial lymphadenitis due to Mycobacterium haemophilum, confirmed using hsp65 gene sequencing and line-probe assays. In resource-limited settings, especially in developing countries, appropriate culture methods and rapid molecular diagnostic tools such as hsp65 gen...
This case report describes a case of presumed acute myocardial infarction in a returned traveler who was later diagnosed to have severe malaria. Emergency coronary angiography was normal and subsequent peripheral blood film was positive for Plasmodium falciparum.
Cryptococcal meningitis is a rare occurrence in systemic lupus erythematosus (SLE). The risk factors of developing this infection are duration of SLE, intensity of glucocorticoid use, and SLE-related intrinsic immune abnormalities. Early recognition and prompt initiation of antifungals can prevent complications and improve survival. There is a dear...
Infections due to Mycobacterium tuberculosis, Burkholderia pseudomallei and non-typhoidal Salmonella cause significant morbidity and mortality throughout the world. These intracellular pathogens share some common predisposing factors and clinical features. Co-infection with two of these organisms has been reported previously but, to our knowledge,...
Questions
Questions (29)
I have performed a study looking at the knowledge of physicians on VAP (ventilator assc. pneumonia ). In this, a total of 16 questions were asked.
Attached are some of the variables (viz. the questions) collected. For the scoring, 2 marks would be given for the right answer and zero for the wrong one. One mark would be given for those who answered "I am not sure".
Can someone show me how do I write a command in R to score their marks based on their responses please?
I need to cite the above for a systemic review that we are doing currently. Can anyone help please?
Is it the BSV x BSV which is n2
Most of the time one may use an email or the likes to disseminate a so called coupon or link into KAP based study so that it can be done at one's own free time
However how do we remove a response that is done to contaminate the data? Do we only rely on good faith of the responders or...
May I have your opinion on the use of IGRA , especially T-spot on LTBI? I have personally experience the lack of reproducibility of T-spot, a first test being borderline positive and the repeated one negative, with only one spot. When a test is so inconsistent, even if it being very specific and sensitive, can we still use it in confidence to diagnose LTBI?
Hypothetically,
a) If a HCW, healthy with low risk of TB infection has a first positive test for healthy employment screening, will you treat them for LTBI once active TB is excluded? or will you repeat the test? what if it comes back borderline, or negative?
b) And if a patient, healthy with low risk of TB infection has a borderline test, does a second negative or positive test mean anything much?
What are your usual practise? Thank you in advance for the opinions.
I have a feeling this is to cover anaerobe but why the difference between these 2 formulations
Hi all
Can someone direct me to human data on ELF (epithelial lining fluid) studies of polymyxin
I found few on animals but yet on humans
May I know whether MIC values "move" when the E-test is performed on a fresh sample vs stocked isolates.
This has been described and may account for vancomycin MIC creep in the case of MRSA. However does this phenomena happen across the different organisms (i.e. Enterobacteriacea )?
What's the difference between PTA and CFR
I understand PTA which is expressed as the percentage of the simulated individuals in Monte Carlo simulation that achieves the optimal PKPD index for a given MIC of an isolate and a given dosing regimen of an antibiotic
But what's CFR as it is derived from PTA and for some reason this percentage becomes even lower and it seems like it's expressed for a given dosing regimen without a specific MIC value but more for the whole organism population
