Alok Srivastava

Indian Institute of Technology Delhi | IIT Delhi · Department of Mechanical Engineering

Poly(lactic acid) (PLA) is one of the most promising biopolymers extensively used in food, packaging, medical and pharmaceutical industries. It is due to favorable physicochemical properties, in‐situ hydrolytic degradation and well‐established processing parameters. However, in medical engineering applications, PLA shows some drawbacks like low cel...

Bioresorbable polymeric stents (BPS) can become a promising alternative over permanent stents, as it reduce in‐stent thrombosis, endothelial dysfunction, and thrombogenicity. Although, a few limitations like uncontrolled degradation, inadequate strength, and lack of radiopacity restrict its application. Thus, a novel bioresorbable radiopaque Mg‐Zn‐...

Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially available Titanium (Ti) dental implants, the bioactivity of Ti is still low. Thus, to achieve both biological and therapeutic activity...

All bioresorbable polymeric implants are radiolucent, making them undetectable under the X-rays. Therefore, to improve their X-ray visibility, the high effective atomic number (Z eff) material such as Pt, Au, Ta, Ba, or its alloy are attached to the body of the bioresorbable implant. However, during the in vivo degradation, these bio-inert heavy me...

PLA and its blends are the most extensively used materials for various biomedical applications such as scaffolds, implants, and other medical devices. The most extensively used method for tubular scaffold fabrication is by using the extrusion process. However, PLA scaffolds show limitations such as low mechanical strength as compared to metallic sc...

Polylactic acid (PLA) and its blends are potential materials for bioresorbable vascular tubular scaffold (TS) manufacturing. The usual method for TS fabrication for intended stent application includes firstly extruding the polymeric tube and then subjected to post-processing operations for tailoring its mechanical properties. In this study, PLA/PCL...

For the medical diagnosis, radiopaque materials (RM) made from high specific gravity elements like Pt, Au, Ta, Iodine, Bromine are either attached or blended or coated on an implant to makes it detectable under X-ray/Fluoroscopy/CT-Scan. RM facilitate the surgeon in an operation theatre to position an implant during the surgery. Mainly, RM are non-...

For the medical diagnosis, radiopaque materials (RM) made from high specific gravity elements like Pt, Au, Ta, Iodine, Bromine are either attached or blended or coated on an implant to makes it detectable under X-ray/Fluoroscopy/CT-Scan. RM facilitate the surgeon in an operation theatre to position an implant during the surgery. Mainly, RM are non-...

Modification of Polylactic acid (PLA), a biopolymer, is a strategy still to be fully explored for the next generation of bioresorbable vascular stent (BVS) biomaterials. With this focus, inclusions upto 5% of Polycaprolactone (PCL) and Magnesium in PLA were tested in the rat subcutaneous model and their cellular and tissue interactions characterize...

Tissue engineering is a field which aims to regenerate damaged tissues by enhancing tissue growth through the porous architecture of the scaffolds which is desired to mimic the human cancellous bone. Mg-based scaffolds are gaining importance in the field of tissue engineering owing to its potential application as a biomaterial. However, fabrication...

A deeper understanding is required to develop a bioresorbable stents (BRS) for cardiovascular diseases. In this work, the biodegradable composite tubes were produced by adding 2% and 4% w/w of Magnesium (Mg) microparticles with Poly-L-lactic acid (PLLA) to achieve synergism effect. Tubes of diameter 3mm and thickness of 150µm were fabricated throug...

Tissue engineering is a field which aims to regenerate damaged tissues by enhancing tissue growth through the porous architecture of the scaffolds which is desired to mimic the human cancellous bone. Mg-based scaffolds are gaining importance in the field of tissue engineering owing to its potential application as a biomaterial. However, fabrication...