Akhilesh Swaminathan

University of Otago

Background Biomarkers have been proposed as surrogate treatment targets for the management of inflammatory bowel disease (IBD); however, their relationship with IBD-related complications remains unclear. This study investigated the utility of neutrophil biomarkers fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) in predicting a complicate...

Background The disease severity index (DSI) for inflammatory bowel disease (IBD) combines measures of disease phenotype, inflammatory activity, and patient-reported outcomes. We aimed to validate the DSI and assess its utility in predicting a complicated IBD course. Methods A multicenter cohort of adults with IBD was recruited. Intraclass correlat...

Background Increased disease activity may be a risk factor for sexual dysfunction (SD) in patients with inflammatory bowel disease (IBD). This study investigated associations between objective measures of disease activity and sexual function. Methods Adults with IBD undergoing ileocolonoscopy were prospectively recruited. Demographic, sexual funct...

We write in response to the commentary from Bourgonje¹ in relation to our manuscript ‘Faecal Myeloperoxidase as a Biomarker of Endoscopic Activity in Inflammatory Bowel Disease’.² This letter highlights several important issues regarding the assessment and validation of novel biomarkers prior to routine clinical use. Our study² showed that the neut...

LINKED CONTENT This article is linked to Swaminathan et al papers. To view these articles, visit https://doi.org/10.1111/apt.17058 and https://doi.org/10.1111/apt.17108

Background and aims Inflammatory bowel disease (IBD), consisting of Crohn’s disease (CD) and ulcerative colitis (UC), is a relapsing-remitting illness. Treat-to-target IBD management strategies require monitoring of gastrointestinal inflammation. This study aimed to investigate faecal myeloperoxidase (fMPO), a neutrophil granule enzyme, as a biomar...

Background/Aims The Disease Severity Index (DSI) is a novel tool to predict disease severity in inflammatory bowel disease (IBD). However, its ability to predict disease complications and the presence of psychosocial comorbidity is unclear. This study prospectively assessed associations between the DSI and psychological symptoms, quality‐of‐life (Q...

LINKED CONTENT This article is linked to Mules et al and Mikocka-Walus & Knowles papers. To view these articles, visit https://doi.org/10.1111/apt.16616 and https://doi.org/10.1111/apt.16639

Background Disease activity may be a risk factor for psychological illness in patients with inflammatory bowel disease (IBD). Aim To correlate objective measures of disease activity with psychological symptoms. Methods Adult patients with IBD undergoing ileocolonoscopy were prospectively recruited. Demographic, psychological symptoms (depression,...

Background and aims: Inflammatory bowel disease (IBD) has a major impact on psychological well-being. How an individual copes with IBD determines quality of life. We aimed to develop a brief, IBD-specific questionnaire to assess coping strategies (IBD-Cope) and to determine its test-retest reliability and validity. Methods: Twenty IBD coping str...

There is general agreement that the lower limit for postprandial venous plasma glucose is the same or higher than for a fasted sample. The finding of a postprandial fall in glucose would therefore have implications for assignment of the lower limit of the normal glucose range. An antecubital venous sample was collected before and one hour after bre...

Background: There is a negative glucose gradient between the capillary and venous systems, produced by glucose uptake into peripheral tissues. This gradient is augmented by oral glucose ingestion in healthy volunteers; thus prandial status may impact on capillary glucose meter performance. Our primary aim was to investigate whether the (capillary-...