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To extend the application of celery (Apium graveolens L.) seeds, the antioxidant and enzymatic inhibitory activities of different fractions and their main flavones were investigated. The n-butanol fractions possessed the highest total phenolic content (TPC) and total flavonoid content (TFC) values. The n-butanol fractions from Northeast China sampl...
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... recent years, the screening of natural antioxidants has received increasing attention. TPC, TFC, and extraction rates of various solvent fractions from different geographic areas of celery seeds in China were evaluated in the current work, as shown in Table 1. Among the five investigated celery seed samples, samples from Northeast China had the highest total extraction yield (11.90%), and Guangxi samples obtained the lowest total extraction yield (8.23%). ...Context 2
... contents of the six flavone glycosides were calculated as milligrams per gram of sample (mg/g sample). The regression equations and correlation coefficients for the six flavone standards are provided in Table S1 and Figure S1. In total, six flavone glycosides were detected in the nBuOH fractions of all five samples, but the different flavone glycosides were significantly different in all samples (p < 0.05). ...Citations
... 32 The antioxidant properties of celery leaves are beneficial in inhibiting the increase in reactive oxygen species (ROS), thereby preventing cell damage. 33 Flavonoids enhance the activity of the antioxidant protection system, beneficially affecting pathological changes caused by ROS and maintaining the integrity of pancreatic cells. 34 Flavonoids act as antioxidants and protect against free radical damage through two mechanisms. ...
Background: The celery plant (Apium graveolens L.) is a widely distributed herbal plant globally known for being a significant source of natural active products, including phenolic compounds and antioxidants demonstrating antidiabetic activity. Previous research findings have indicated the impact of celery leaf extract on reducing blood glucose levels. However, up to now, there is a dearth of research investigating the potential effect of celery leaf extract on the regeneration of pancreatic beta cells in mice with diabetes models.Objective: This study aims to determine the effect of the ethanol extract of celery leaves on the number of pancreatic cells in Streptozotocin (STZ)-induced mice.Method: This research method uses a randomized controlled group posttest only design. Experimental animals were divided into five groups, including a group of experimental animals in a healthy condition, the group with hyperglycemia, hyperglycemia group with celery extract at 200 mg/kg BW, hyperglycemia group with celery extract at 400 mg/kg, and hyperglycemia group with extract celery is 800 mg/kg BW. Termination was performed on day 60 after therapy and pancreas hematoxylin and eosin staining. They are counting the number of cells with a photo slide with 400x magnification in 5 fields of view—statistical analysis using One-Way ANOVA.Results: The study revealed that celery extract could increase the number of pancreatic cells compared to the control group (P<0.002). Notably, the highest increase in pancreatic cell count was observed in the group administered with 400 mg/BW of celery extract.Conclusion: Celery leaf extract effectively increased the number of beta cells in vivo.
... The 4 ′ -OH hydrogroup enhances α-glucosidase inhibition activity (Figure 3e) [61] to acarbose. It decreases the rheumatoid arthritis risk in diabetic patients. ...
Chrysoeriol is an active ingredient derived from the Chinese medicinal herb (CMH) "Lonicerae japonicae flos" in the dried flower bud or bloomed flower of Lonicera japonica Thunberg. Dermatoses are the most common diseases in humans, including eczema, acne, psoriasis, moles, and fungal infections, which are temporary or permanent and may be painless or painful. Topical corticosteroids are widely used in Western medicine, but there are some side effects when it is continuously and regularly utilized in a large dosage. Chrysoeriol is a natural active ingredient, nontoxic, and without any adverse reactions in the treatment of dermatological conditions. Methods: Nine electronic databases were searched, including WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), without regard to language constraints. The pharmacological activities of chrysoeriol from Lonicerae japonicae flos to fight against skin diseases were explained and evaluated through the literature review of either in vitro or in vivo studies. Results: Chrysoeriol decreased the mRNA levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α. These were transcriptionally regulated by NF-κB and STAT3 to combat skin inflammation. It also showed promising actions in treating many skin ailments including wound healing, depigmentation, photoprotection, and antiaging. Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated.
... They comprise stilbenes, tannins, coumarins, phenolic acids and flavonoids (Abotaleb et al., 2019). Polyphenols are natural antioxidants in fruits and vegetables (Abotaleb et al., 2019;Zhang et al., 2022). The most predominant polyphenolic compounds in the plant kingdom are phenolic acids and flavonoids (Chen et al., 2022). ...
Background
This study investigates the toxic activity of Artemisia judaica ethanolic extract (ArEx) as well as its phenolic fraction (ArPh), and terpenoid fraction (ArT) against Cryptosporidium parvum ( C. parvum ) oocysts.
Methods
Over a 4 months period, estimation of the total phenolic (TPC), total flavonoids (TFC), and total terpenoids contents (TTC) in ArEx; investigation of the in vitro antioxidant activity of ArEx, ArPh, and ArT; evaluation of ArEx, ArPh, and ArT toxic activity against C. parvum oocysts using MTT assay; parasitological analysis on ArPh-treated C. parvum oocysts and comet assay were performed both in vitro and in vivo (infectivity).
Results
The ArEx TPC, TFC, and TTC was 52.6 ± 3.1 mgGAE/g, 64.5 ± 3.1 mg QE/g, and 9.5 ± 1.1 mg Linol/g, respectively. Regarding the phytochemical in vitro antioxidant activity, the ArPh exhibited the highest antioxidant activity compared to the ArEx and ArT. The ArPh showed promising free radical scavenging activity of DPPH and ABTS •+ with IC 50 values of 47.27 ± 1.86 μg/mL and 66.89 ± 1.94 μg/mL, respectively. Moreover, the FRAP of ArPh was 2.97 ± 0.65 mMol Fe ⁺² /g while its TAC was 46.23 ± 3.15 mg GAE/g. The ArPh demonstrated toxic activity against C. parvum oocysts with a potent IC 50 value of 31.6 μg/mL compared to ArT (promising) and ArEx (non-effective). ArPh parasitological analysis demonstrated MIC 90 at 1000 μg/ml and effective oocysts destruction on count and morphology. ArPh fragmented oocysts nuclear DNA in comet assay. Beginning at 200 μg/mL, ArPh-treated oocysts did not infect mice.
Conclusion
To combat C. parvum infection, the phenolic fraction of A. judaica L. shows promise as an adjuvant therapy or as a source of potentially useful lead structures for drug discovery.
... However, the stress response in celery seeds under the conditions of this test was not characterized by phenolics accumulation since the assay revealed no statistical difference among treatments for the total phenolic content (p > 0.05) (Fig. 2). Moreover, the total phenolic content in celery seeds was found to range from 48.83 to 54.90 mg GAE g − 1 , which is in accordance with the reports by other authors, such as Zhang et al. (2022), who reported a mean of 62.36 mg GAE g − 1 and Ksouda et al. (2018) who found a mean of 49.0 mg GAE g − 1 in celery seeds. ...
Controlled elicitation induces metabolite biosynthesis and enhances crop productivity by activating plant defense in a dose-dependent manner. However, elicitation studies often overlook the concept of hormesis. Here, we describe the response of celery seeds, a valuable source of bioactive phthalides, to elicitation from the hormesis approach. We evaluated 0.1, 1, and 10 mM salicylic acid and 15, 150, and 1500 µg mL −1 chitosan. A gas chromatography mass spectrometry (GC/MS) analysis revealed that Senkyunolide A is the major compound in celery seed CH 2 Cl 2 extract. At the highest dose (10 mM), salicylic acid increased 2-fold Senkyunolide A content (15.2 ± 1.1 mg g −1) but also affected germination and seedling growth compared to the control. Chitosan induced a hormetic dose-response of antioxidant defense and seedling development variables, increasing 1.5-fold Senkyunolide A content (11.1 ± 1.5 mg g −1) and improving germination time at 15 µg mL −1 compared to the control. These findings show that both elicitors effectively increase the concentration of industrially relevant metabolites in celery seed.
... In addition, the inhibitory activity was enhanced significantly with the increasing number of substitutions of the B-ring. When compared to the chemical structure of 6 and 8, which has the same hydroxylation pattern, the methyl substitution did not significantly contribute to the activity consistent with the literature [51]. The fact that 6 and 8 possessing the 3′,4′disubstituted exhibited good inhibitory effects on α-glucosidase was fully consistent with the literature [50]. ...
