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![Pooled analysis of the anti-trismus effect (p < 0.05) [29,30].](publication/361019670/figure/fig1/AS:1179022394437656@1658112252590/Pooled-analysis-of-the-anti-trismus-effect-p-005-29-30.png)
Pooled analysis of the anti-trismus effect (p < 0.05) [29,30].
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![Figure 4. Pooled analysis of the anti-trismus effect (p < 0.05) [29,30].](publication/361019670/figure/fig1/AS:1179022394437656@1658112252590/Pooled-analysis-of-the-anti-trismus-effect-p-005-29-30_Q320.jpg)
The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selection criteria and with high methodological quality,...
Contexts in source publication
Context 1
... the combined assessment of the trismus showed a difference in favor of methylprednisolone, when compared to other drugs after 7 postoperative days (OR = −312; 95% IC=−522 to −1.01; I 2 = 12%; p = 0.004; Figure 4). ...
Citations
... However, another meta-analysis that evaluated the efectiveness of methylprednisolone against placebos in M3M surgery suggested that methylprednisolone signifcantly reduced pain, edema, and trismus in the early postoperative period [25]. Another meta-analysis evaluating the efectiveness of methylprednisolone against other antiinfammatory drugs showed that methylprednisolone was signifcantly better in reducing trismus after 7 postoperative days [26]. ...
The corticosteroids have been used for preemptive management of surgical sequelae after mandibular third molar extraction. The aim of this article was to review the efficacy of methylprednisolone versus dexamethasone in the management of postsurgical pain, swelling, and trismus after mandibular third molar surgery. Randomized, double-blinded studies from PubMed, CINAHL, Scopus, DOSS, Cochrane central, and Web of Science were identified by using a search strategy. Randomized controlled trials evaluating the efficacy of use of dexamethasone versus methylprednisolone for mandibular third molar extraction were only considered. The studies involving the use of any other corticosteroid agent were excluded. Outcomes assessed were postoperative pain, the number of rescue analgesics required, swelling, trismus, and adverse events. The search strategy yielded 1046 articles for title and abstract screening, out of which only seven studies were included in the systematic review after full text screening. There was considerable heterogeneity between the studies with regards to the method as well as the parameters assessed. Risk of bias was low in three studies and unclear in other four studies. On pooled analyses, there was no significant difference with respect to pain, rescue analgesics, and swelling in the test and the control group. Forest plot analysis showed that dexamethasone had lesser trismus in early postoperative period (postoperative day 2) as compared to methylprednisolone. None of the included studies reported any adverse effects. Both the corticosteroids have similar efficacy in reducing the postoperative pain and swelling; however, dexamethasone showed statistically significant difference from methylprednisolone in reducing trismus (estimated standardized mean difference of −0.69 mm; 95% CI: −1.01 to −0.38; p
