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... results from the in vitro assay show that aniline and 1,4-diaminobenzene display a complete loss of MtHb activity, whereas 4-nitroaniline displayed ca. 50% the MtHb activity of PAPP (Table 3). ...Context 2
... the aromatic amine moiety unmodified in all the molecules tested (Table 3), this suggests the importance of the ketone moiety and the electronic influence that it introduces to the ring of the aromatic amine. The fact that any change in electronics at the para position substituent also brings about such a dramatic loss in MtHb activity suggests that electronic influence at this area is quite significant, and that there may possibly be an optimal electronic influence on the ring that promotes maximum redox cycling, hence high accumulation of the toxic agent. ...Context 3
... results from the in vitro assay show that aniline and 1,4-diaminobenzene display a complete loss of MtHb activity, whereas 4-nitroaniline displayed ca. 50% the MtHb activity of PAPP (Table 3). ...Context 4
... the aromatic amine moiety unmodified in all the molecules tested (Table 3), this suggests the importance of the ketone moiety and the electronic influence that it introduces to the ring of the aromatic amine. The fact that any change in electronics at the para position substituent also brings about such a dramatic loss in MtHb activity suggests that electronic influence at this area is quite significant, and that there may possibly be an optimal electronic influence on the ring that promotes maximum redox cycling, hence high accumulation of the toxic agent. ...Similar publications
Fluoride is a widespread environmental pollutant that at high levels exerts numerous deleterious effects on human health. The toxic effects of fluoride are a matter of serious concern since many countries have regions of endemic fluorosis. The main source of fluoride exposure for humans is intake of contaminated groundwater. Fluoride is absorbed fr...
