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Liver ex vivo normothermic machine perfusion schematic. Reprinted with permission from Hefler et al. Biomedicines (2022) Oct 6;10(10): 2496. Created in PowerPoint (v19.0, Microsoft Corp.).
Source publication
Background
Ischemia/reperfusion injury (IRI) is an inherent problem in organ transplantation, owing to the obligate period of ischemia that organs must endure. Cyclosporine A (CsA), though better know as an immunosuppressant, has been shown to mitigate warm IRI in a variety of organ types, including the liver. However, there is little evidence for...
Context in source publication
Context 1
... completion of the cold ischemic period, livers were perfused for 12 hours according to our previously established protocol [14,15]. As illustrated in Figure 2, perfusate is circulated via 2 BPX-80 Bi-Medicus centrifugal pumps (Medtronic of Canada, Ltd., Brampton, ON, Canada). One pump directs perfusate through an EOS ECMO oxygenator (Sorin Group Canada, Inc., Burnaby, BC, Canada) before entering the hepatic artery, while the second pump directs perfusate through a MYOtherm XP heat exchanger (Medtronic of Canada, Ltd., Brampton, ON, Canada) before it enters the portal vein. ...
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