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Scrub typhus and Japanese spotted fever-both rickettsial diseases-are endemic and notifiable in Japan and may cause a fatal outcome without prompt treatment. Here we present the first case of a concurrent sympatric infection of both diseases with grade II evidence. A 67-year-old woman, after a single event of potential exposure to the pathogens, pr...
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... was initially diagnosed with a viral infection and sent back home without medication. Significant thrombocytopenia, elevated myogenic enzymes, and elevated C-reactive protein were revealed by laboratory blood tests on day 3, and renal involvement was suggested by urine analysis (Table 1). ...Context 2
... was initially diagnosed with a viral infection and sent back home without medication. Significant thrombocytopenia, elevated myogenic enzymes, and elevated C-reactive protein were revealed by laboratory blood tests on day 3, and renal involvement was suggested by urine analysis (Table 1). ...Similar publications
Background:
Reports of human rickettsial infection in Indonesia are limited. This study sought to characterize the epidemiology of human rickettsioses amongst patients hospitalized with fever at 8 tertiary hospitals in Indonesia.
Methods:
Acute and convalescent blood from 975 hospitalized non-dengue patients was tested for Rickettsia IgM and IgG...
Diseases caused by Rickettsiales bacteria are a global public health problem. To better understand the diversity and origins of Rickettsiales infection in humans and animals, we sampled 134 febrile patients, 173 rodents and 43 shrews, as well as 358 ticks, from two cities in Jiangsu and Jiangxi provinces, China. Our data revealed a relatively high...
Background
Scrub typhus is a mite-borne infectious disease caused by Orientia tsutsugamushi . Few follow-up studies have assessed antibody titers using serologic tests from various commercial laboratories and the Korea Centers for Disease Control and Prevention (KCDC).
Methods
A prospective study to assess the antibody titers in patients with scru...
Objectives:
To develop a method to enable the large-scale antimicrobial susceptibility screening of Orientia tsutsugamushi clinical isolates, using one timepoint and one concentration of antibiotics to considerably speed up the time to result.
Methods:
Growth, harvesting, multiplicity of infection (moi) and the day to determine the MICs were opt...
Citation: Pokhrel, A.; Rayamajhee, B.; Khadka, S.; Thapa, S.; Kapali, S.; Pun, S.B.; Banjara, M.R.; Joshi, P.; Lekhak, B.; Rijal, K.R. Seroprevalence and Clinical Features of Scrub Typhus among Febrile Patients Attending a Referral Hospital in Kathmandu, Nepal. Trop. Med. Infect. Dis. 2021, 6, 78. https://doi.
Citations
... infection of scrub typhus with dengue fever [14], leptospirosis [15], Japanese spotted fever [16], Q fever [17], and acute hepatitis A were reported [18]. ...
Scrub typhus (Tsutsugamushi disease) is a zoonotic bacterial infection with three main clinical manifestations, fever, skin eruption, and eschar; a necrotic lesion of the skin presented at the site of an infected chigger bite, pathognomonic of scrub typhus. The World Health Organization (WHO) in 1999 stated that: scrub typhus is probably one of the most underdiagnosed and an underreported disease that often requires hospitalization. Scrub typhus is a serious health problem especially in the region known as Tsutsugamushi Triangle. Without appropriate treatment, the case fatality of scrub typhus can reach higher than 30% as a result of multi-organ failure. Scrub typhus is the most common rickettsial infection in Japan and was classified as fourth notifiable infectious disease in 1999. In this article, we review the history of scrub typhus in Japan, and provide new information, chief events and current status of epidemiology. For a better understanding of scrub typhus, a typical case of Tsutsugamushi disease was presented.
Japanese spotted fever (JSF) is an uncommon but potentially fatal infection transmitted by tick bites. We herein report a fulminant case of JSF infection that occurred in an immunocompetent adult that was complicated by disseminated intravascular coagulation and hemophagocytic lymphohistiocytosis (HLH). We discuss the difficulty in making the diagnosis and identifying the complication of HLH in our patient. HLH is a rare complication of rickettsiosis, and this is the first reported case in English of JSF complicated by HLH in an immunocompetent adult. Secondary HLH caused by rickettsiosis requires a different treatment from primary HLH. Rickettsiosis must therefore be considered in patients with HLH.
Objective: To investigate to investigate significance of C-reactive protein (CRP) in patients with trauma on arrival.
Materials: From September 2017 to February 2018, a medical chart review was retrospectively performed for all patients with trauma who were admitted to our department.
Methods: The subjects were divided into two groups: a CRP-negative group (initial CRP level ≤0.3 mg/dl) and a CRP-positive group (>0.3 mg/dl). For the CRP-positive group, we additionally investigated the cause of the increased level of CRP.
Results: There were 33 cases in the CRP-positive group and 168 in the CRP-negative group. The age and ratio of lymphocytes in the CRP-positive group was significantly higher than those in the CRP-negative group. Twenty-two to twenty-eight of the 33 cases (67-85%) had an infection, 3 of 33 (9%) had a delayed visit (over 24 h from the onset of the trauma) to the emergency department, and 2 cases (6%) had malignancy in the CRP-positive group. All subjects with an increased CRP level on arrival potentially had underlying diseases that might have caused their trauma.
Conclusion: Some traumatized patients may have elevated CRP levels on arrival due to underlying diseases capable of causing trauma. An increased initial level of CRP did not significantly affect the clinical outcome; however, physicians should pay attention to the cause of the increased CRP level, which may affect the patient’s outcome. Exploring increased CRP levels may be useful for identifying the mechanism underlying the occurrence of trauma.
